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Services & Instrumentation

Bayview CPAL

Bayview CPALLaboratory benches are equipped with materials to process and prepare samples for bioanalytical testing.
Bayview CPALThe CPAL has capacity for short and long-term freezer storage. The biorepository is equipped with remote and real-time temperature monitoring.
Bayview CPALLiquid chromatographic-mass spectrometric (LC-MS) instruments can facilitate the selective and sensitive quantification of target biomolecules.
Bayview CPALLiquid chromatographic-mass spectrometric (LC-MS) instruments can facilitate the selective and sensitive quantification or identification of biomolecules.
Bayview CPALAnalytical areas are customized for management and extraction of target molecules from numerous biological matrices.

EBMC CPAL

EBMCThe CPAL is equipped with biosafety cabinets for the management and processing of biological samples.
EBMC CPALThe CPAL biological suite is equipped with instrumentation for cell isolation from tissue, biopsy incubation, and cell counting.
EBMC CPALThe CPAL also has expertise and capacity to perform targeted genetic analysis to better understand PK-PD relationships.

Available Assays

MatrixCollection DeviceAnalytes
PlasmaK2EDTACabotegravir, Dapivirine, Efavirenz, Emtricitabine, Ethambutol, Etravirine, IQP-0528, Isoniazid, Maraviroc, Medroxyprogesteroneacetate, Moxifloxacin, PA-824, Pyrazinamide, Raltegravir, Rifampin, Rifapentine, Desacetyl-rifapentine, Rilpivirine, Tenofovir,Tenofovir alafenamide fumarate
PBMCsCPTTenofovir-diphosphate
Dried Blood SpotsWhatmanRifapentine, Desacetyl-rifapentine
TissueCervical, vaginal, colonicCabotegravir, Dapivirine, Emtricitabine, Ethambutol, Etravirine, Isoniazid, Maraviroc, Moxifloxacin, PA-824, Pyrazinamide, Raltegravir, Rifapentine, Rifampin, Rilpivirine, Tenofovir, Tenofovir-diphosphate
Breast MilkWholeDapivirine, Emtricitabine, Tenofovir
Cerebrospinal FluidN/AEfavirenz, Tenofovir, Emtricitabine
Cervicovaginal FluidDacron SwabDapivirine, Emtricitabine, Maraviroc, Tenofovir, Tenofovir disoproxil fumarate
Cervicovaginal FluidMerocal SpongeDapivirine, Emtricitabine, Maraviroc, Tenofovir
Cervicovaginal FluidTear StripDapivirine, Maraviroc
Cervicovaginal LavageN/ADapivirine, Emtricitabine, Maraviroc, Tenofovir, Tenofovir disoproxil fumarate
Rectal FluidWeck Cel SpongeEmtricitabine, Tenofovir
Rectal FluidMerocel SpongeEmtricitabine, Maraviroc, Tenofovir
Rectal FluidDacron SwabEmtricitabine, Dapivirine, Maraviroc, Tenofovir, Rilpivirine

Assays are validated in accordance with the FDA, Guidance for Industry, Bioanalytical Method Validation.

Collaborators and Helpful Links

The CPAL is an integral part of the Pharmacology Cores of the HIV Prevention Trials Network (HPTN) and the Microbicide Trials Network (MTN).