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A Publication of the Patrick C. Walsh Prostate Cancer Research Fund

 


Individualized Treatment Through Discovery

A message from Alan W. Partin, M.D., Ph.D. in DISCOVERY 2020

Founders' Circle: 2020

Thank you to those who have committed $500,000 or more to The Patrick C. Walsh Prostate Cancer Research Fund.

The Urinary Microbiome Begins in Childhood

Sfanos and her team found bacteria in urine and fecal samples of boys as young as three months.

Reducing Opioids after Radical Prostatectomy

“We saw a reduction in opioid prescribing by nearly 47 percent, a reduction in opioid use by nearly 27 percent, and increased disposal of leftover opioids by nearly 14 percent.”

Preventing Blood Clots After Radical Prostatectomy

They don’t happen often, but Brady urologists would like to prevent them altogether: blood clots in the legs or lungs after radical prostatectomy.

The Father of Active Surveillance

Carter, retiring as the Bernard L. Schwartz Distinguished Professor of Urologic Oncology, reflects on his 32 years at the Brady.

The H. Ballentine Carter, M.D., Prostate Research and Innovation Fund

“We know a lot, but certainly there is more to learn, about the markers, the disease itself, and how to deal with it when something should be done.”

Fix the Gleason Grades!

At many hospitals worldwide, Gleason scoring is still less accurate. Unfortunately, says Epstein, “today only a minority of published articles on prostate cancer group Gleason scores accurately."

High-Grade Prostate Cancer and Inherited Gene Mutations

“We found that three genes, ATM, BRCA2, and MSH2, were mutated at a significantly higher rate in high-grade cancers.”

Oligometastasis: Good News from the ORIOLE Study

Now, we are pleased to report, the results of the Baltimore ORIOLE multicenter trial are even better than radiation oncologist Phuoc Tran, M.D., Ph.D. hoped.

Discovered: A “Gatekeeper” Gene for CRPC

Lupold sees PDCD4 levels as a key “thermostat” for prostate cancer, whose presence or absence helps determine whether the cancer cells will die, or go on to become independent of hormonal control.

Racial Differences in Prostate Cancer: New Genetic Targets

Why are African American men 1.5 times more likely to get prostate cancer, and more than twice as likely to die of it as men of European descent? Brady investigators have discovered critical, inherited genetic mutations in men of African descent. 

Aggressive Cells in Primary Tumors

Under the microscope, pathologists can see it: differences in prostate cancer cells, some clearly more ragged-looking and aggressive than other, more well-defined and orderly cells. “But we don’t know why some prostate tumors behave more aggressively,” says Brady pathologist Tamara Lotan, M.D., who teamed up to look for answers.

For Some Men with Certain Genes: PARP Inhibitors Instead of ADT

“We are using two PARP inhibitors, olaparib and rucaparib, in two clinical trials to maximize clinical benefit while avoiding the long-term toxicity of ADT.”

Uneven Accuracy in IHC Testing

Brady scientists provide numerous examples of validated assays, literature and other resources to help pathologists and scientists find the right IHC antibodies and assays.

Special Delivery to Metastatic Prostate Cancer: PSMA-Targeted Poison

This protoxin is a copycat killer: like immune cells, it pokes lethal holes in cancer cells. Unfortunately, so far prostate cancer has proven to be resistant to immunotherapy. So how can we get to metastatic prostate cancer cells to kill them? Brady scientists have come up with a solution.

The Keystone to Resistance after Chemotherapy for Prostate Cancer

When cancer cells are treated with chemotherapy, the Keystone cancer cells stop dividing, and seem to hibernate. Because chemotherapy kills cells that are dividing, “the Keystone cancer cells survive.”

Coming Soon: A New Urine Test for Prostate Cancer

Prostate-specific RNA in the urine may lead to a new test for clinically significant prostate cancer, and may show which men have more aggressive disease.

The Patrick C. Walsh Prostate Cancer Research Fund: 2019 Awardees

Since its inception in 2005, The Patrick C. Walsh Prostate Cancer Research Fund has awarded millions of dollars to Johns Hopkins scientists in every discipline. Learn what the 2019 awardees accomplished.

Sarcomatoid Bladder Cancer: Encouraging Responses to New Regimen

New hope for patients with a rare, extremely aggressive form of bladder cancer: “very encouraging responses” to an intense, triple-drug, neoadjuvant chemotherapy approach, followed by cystectomy (surgical removal of the bladder).

Upper Tract Urothelial Cancers: Who Will Benefit from Chemotherapy?

When it comes to chemotherapy for urothelial cancer, does location matter? Hopkins scientists are working to find out.

Bladder Immune Cells May Determine Response to Chemotherapy

Scientist Woonyoung Choi, Ph.D., who led genomic studies that identified the basal and luminal molecular subtypes of bladder cancer, has discovered that the immune system plays a powerful role in how patients respond to chemotherapy.

Evaluating Alternatives to BCG: Is Combination Chemotherapy the Next Frontier?

Maintenance dosing of intravesical combination chemotherapy “leads to more durable responses than induction treatment alone.”

Can Biomarkers Predict Who Will Benefit from Chemotherapy in Bladder Cancer?

New tests could identify who will benefit from chemotherapy, and spare those who will not.

Bivalacqua Wins Gold Cystoscope Award

Brady urologist Trinity Bivalacqua, M.D., Ph.D., the R. Christian B. Evensen Professor, has received this year’s Gold Cystoscope Award, one of the highest honors awarded by the American Urological Association.

Bladder Immune Molecular Subtypes Can Help Determine Who May Benefit from Chemotherapy for Urothelial Cancer

“In the field of bladder cancer, we are desperately trying to find biomarkers for the selection of patients for NAC before surgery,” Bivalacqua says.

Blue Light Shows Urothelial Cancer

In a recent study, Matoso and colleagues assessed the sensitivity of blue light cystoscopy, and compared the results with the final pathology diagnoses. They found blue light cystoscopy allows them to detect CIS that would have been under-diagnosed with the conventional white light cystoscopy.

Physical, Mental Health and Active Surveillance for Kidney Cancer

“Half of the patients who chose delayed intervention did so because their cancer grew or changed; the other half decided to have surgery because of anxiety or uncertainty about their cancer. “The good news is that none of these patients had a recurrence of cancer."

Potential Biomarker for Kidney Cancer: The Immune System?

Can what’s happening to the immune system in kidney cancer be tracked? Are there biological footprints that might lend themselves to a test? Quite possibly!

Conditional Survival After Kidney Cancer

“How long am I going to live?” There’s a new way to answer this question, and it’s called conditional survival.

Much-Needed Guidelines for Treating Testicular Cancer

In May, the American Urological Association (AUA) released its first-ever guidelines for the management of early-stage testicular cancer, supported by evidence from the Evidence-based Practice Center (EPC) at Johns Hopkins.