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Effective cancer prevention and control requires an understanding of the causes and risk factors for cancer and development and testing of ways to prevent cancer and improve the quality of cancer care. The goal of the Cancer Prevention and Control Program is to conduct population-focused collaborative, multispecialty research. This includes observational, laboratory and clinical studies of prevention methods to identify new approaches to early detection and better strategies to reduce cancer incidence, recurrence, progression and death. Research is primarily focused on populations with an increased risk of cancer occurrence, the role of viruses in cancer development and improving cancer care, including palliative care. In Maryland, our Cancer Prevention and Control experts are conducting important research aimed at overcoming cultural and institutional barriers and increasing minority participation in clinical trials, with a particular focus on prostate, breast, colorectal, and HPV-related cancers. Kimmel Cancer Center physicians and investigators work collaboratively with Maryland elected officials and health experts to develop and implement the Maryland Comprehensive Cancer Control Plan, and they participate in the Maryland State Council on Cancer Control. The Maryland Cigarette Restitution Fund at Johns Hopkins helps support new faculty members and population-focused research projects.