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A Children?s Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens
Johns Hopkins Kimmel Cancer Center in Baltimore
The purpose of this study is to collect leukemia cells and normal blood cells from patients with ALL that relapse, and to store them for use in future research studies.
Age less than 31 years Patient has ALL at first or subsequent marrow relapse with greater than or equal to 25% blasts in the bone marrow and/or peripheral blood. No systemic anti-leukemic treatment has been administered for the current relapse.
we would like to take a small amount (about 5 ml or 1 teaspoonful) of extra bone marrow and store it for future research studies. Bone marrow cells, genetic material (DNA or RNA) taken from bone marrow and blood cells, and proteins from the blood or bone marrow samples will be shipped to and stored at the Childrenâ??s Oncology Group (COG) ALL cell bank, along with other samples taken from patients treated at COG centers. If there are leukemia cells in the blood stream, we would also like to get 5 ml (1 teaspoonful) of your blood before treatment starts for future research studies. We would also like to get some normal blood cells so that researchers can study differences between normal and leukemia cells. With your permission, 5 ml of blood will be drawn at the time you are first diagnosed with relapsed leukemia, and/or at the end of the first month of treatment. These samples will be stored and may be used for future research studies to learn more about what causes leukemia and about how to make treatment better. Samples stored in the cell bank are identified by a number, not by your name.
07/23/2017 05:03 AM