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Phase II Study of Post-Operative Stereotactic Radiosurgery for Solid Tumor Spine Metastases
Johns Hopkins Kimmel Cancer Center in Baltimore
This research is being done to see whether radiosurgery (5 high doses of radiation) following surgery for spine metastases works better than standard radiation therapy (10-14 low doses of radiation). Since radiosurgery delivers a higher dose of radiation therapy over a shorter time period, it is possible that it causes more side effects than standard radiation. It is also possible that radiosurgery may not be as effective as standard radiation.
- Age less than or equal to 12 years - Histologically proven solid tumor malignancy with metastasis to the spine. Diagnosis may be acquired from needle biopsy, cytology, or surgical biopsy or resection. - Radiographic evidence of spinal metastasis is required and may be obtained from radionuclide bone scans, computed tomography imaging, and magnetic resonance imaging. Other studies may be used with principal investigator approval, but plain radiograph (X-ray) alone is not sufficient. - The patient must have undergone surgical resection (gross total, subtotal, or biopsy) of the spinal lesion(s) no more than 12 weeks prior to SRS treatment. - Treating physician must deem that SRS is appropriate treatment for the metastatic spinal lesion(s). - Each SRS target must be the equivalent of ï¿½3 vertebral levels - The patient must have a Karnofsky Performance Score of 40 or greater.
Have five treatments of radiation to your spine. The number of radiation treatments is less than standard radiation, but the radiation dose given each day is higher.
04/23/2017 05:03 AM