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Title:
A Phase I Clinical Trial Assessing the Safety and Feasibility of Administration of pNGVL4a-CRT/E7(detox) DNA Vaccine using the Intramuscular TriGridTM Delivery System in Combination with Cyclophosphamide in HPV-16 Associated Head and Neck Cancer Patients
Protocol Number:
J11129
Phase:
Phase I
Physician:
Joseph Califano
Purpose:
This study, to be conducted at the Johns Hopkins Hospital, in Baltimore, Maryland, will give patients a cancer vaccine following chemotherapy and radiation therapy as adjuvant therapy in HPV-related head and neck cancer.
Eligibility:
Any patient with advanced stage HPV-HNSCC who are planning to be treated with standard of care concurrent cisplatin and radiation therapy are eligible for the study.
Treatment:
This study, to be conducted at the Johns Hopkins Hospital, in Baltimore, Maryland, will give patients a cancer vaccine following chemotherapy and radiation therapy as adjuvant therapy in HPV-related head and neck cancer. A cancer vaccine is a type of treatment for cancer based on the idea that the immune system (the system in the body that fights infection) can be activated to destroy virus-related cancer cells. A vaccine is a way of delivering an antigen (a protein unique to the cancer cell or virus) to the immune system so that it recognizes the antigen as foreign and can destroy any cells that express that antigen. Any patient with advanced stage HPV-HNSCC who are planning to be treated with standard of care concurrent cisplatin and radiation therapy are eligible for the study. We plan to enroll a total of 21 patients into this study.
Population:
Adult
Last Update
07/24/2014 04:10 AM
 

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