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This study, to be conducted at the Johns Hopkins Hospital, in Baltimore, Maryland, will give patients a cancer vaccine following chemotherapy and radiation therapy as adjuvant therapy in HPV-related head and neck cancer. A cancer vaccine is a type of treatment for cancer based on the idea that the immune system (the system in the body that fights infection) can be activated to destroy virus-related cancer cells. A vaccine is a way of delivering an antigen (a protein unique to the cancer cell or virus) to the immune system so that it recognizes the antigen as foreign and can destroy any cells that express that antigen. Any patient with advanced stage HPV-HNSCC who are planning to be treated with standard of care concurrent cisplatin and radiation therapy are eligible for the study. We plan to enroll a total of 21 patients into this study.