2009
Mini Transplant May Reverse Severe Sickle Cell Disease
Results of a preliminary study by scientists at the National Institutes of Health and Johns Hopkins show that "mini" stem cell transplantation may safely reverse severe sickle cell disease in adults. Using this procedure, nine of 10 patients treated have normal red blood cells and reversal of organ damage caused by the disease.
Low Cholesterol May Shrink Risk for High-Grade Prostate Cancer
Men with lower cholesterol are less likely than those with higher levels to develop high-grade prostate cancer, an aggressive form of the disease with a poorer prognosis, according to results of a Johns Hopkins collaborative study. The epidemiologists provided evidence that having lower levels of heart-clogging fat may cut a man's risk of this form of cancer by nearly 60 percent.
Guide on Lung Cancer in "Never-Smokers": Different Disease, Different Treatments
A committee of scientists led by Johns Hopkins investigators published a new guide to the biology, diagnosis and treatment of lung cancer in never-smokers, the sixth largest cancer killer, fortifying measures for what physicians have long known is a very different disease than in smokers.
Diarrheal Bacteria Causes Some Colon Cancers
Johns Hopkins scientists figured out how bacteria that cause diarrhea may also be the culprit in some colon cancers. The investigators say that strains of the common Bacteroides fragilis (ETBF), which they liken to the "H. pylori of colon cancer," dupe immune system cells into permitting runaway colon tissue inflammation, a precursor for malignant growth.
Genetic Changes Outside Nuclear DNA Suspected to Trigger More Than Half of All Cancers
A buildup of chemical bonds on certain cancer-promoting genes, a process known as hypermethylation, is widely known to render cells cancerous by disrupting biological brakes on runaway growth. Johns Hopkins scientists provided evidence that the reverse process — demethylation — which wipes off those chemical bonds may also trigger more than half of all cancers. One potential consequence of the new research is that demethylating drugs now used to treat some cancers may actually cause new cancers as a side effect.
Personalized Genome Sequencing Reveals Coding Error
Johns Hopkins Kimmel Cancer Center scientists used "personalized genome" sequencing on an individual with a hereditary form of pancreatic cancer to locate a mutation in a gene called PALB2 that is responsible for initiating the disease. The discovery marks their first use of a genome scanning system to uncover suspect mutations in normal inherited genes. The findings, they say, underscore the value of so-called "personalized genome" sequencing, which decodes a person's genes and compares the changes to those found in healthy people.
Two Gene Mutations Linked to Most Common Brain Cancers
Scientists at the Johns Hopkins Kimmel Cancer Center and Duke University Medical Center linked mutations in two genes, IDH1 and IDH2, to nearly three-quarters of several of the most common types of brain cancers known as gliomas. Among the findings: people with certain tumors that carry these genetic alterations appear to survive at least twice as long as those without them.
2008
Personalized Blood Test Monitors Success Of Cancer Therapies
Johns Hopkins Kimmel Cancer Center researchers developed a novel test to measure tumor-derived DNA in the bloodstream. The blood test, based on the unique genetic fingerprint contained within the genome of every cancer, can not only detect the presence of tumor, but track its progress.
Genetic Blueprints Revealed for Brain, Pancreatic Cancers
The complete genetic blueprint for lethal pancreatic cancer and brain cancer was deciphered by a team at the Johns Hopkins Kimmel Cancer Center. The studies were led by the same group who completed maps of the breast cancer and colorectal cancer genomes. The map evaluated mutations in virtually all known human protein-encoding genes, comprised of more than 20,000 genes, in 24 pancreatic cancers and 22 brain cancers. A core set of regulatory gene processes and pathways, about a dozen for each tumor type, were found to be altered in the majority of tumors studied by the researchers.
Genome Atlas Group Reports on Brain Cancer Genes
Johns Hopkins Kimmel Cancer Center investigators were part of The Cancer Genome Atlas (TCGA) which reported results from its first comprehensive study focused on the deadly brain cancer glioblastoma. They reported findings on the MGMT gene, first linked to GBM in 1998 by Johns Hopkins investigators who found it was altered by a cellular process known as methylation. In 2002, they discovered that the gene alteration makes brain cancer cells more responsive to anticancer drugs known as alkylating agents.
Radiation Therapy Prolongs Life in Men with Recurrent Prostate Cancer
Men whose tumors recur after prostate cancer surgery are three times more likely to survive their disease long term if they undergo radiotherapy within two years of the recurrence. Surprisingly, survival benefits were best in men whose new tumors were growing fastest, according to results of a "look-back" study of 635 men by Johns Hopkins Medical Institutions researchers reported June 18 in the Journal of the American Medical Association.
DNA Detectives Find Genetic Markers for Lung Cancers Most Likely to Recur
Researchers at the Johns Hopkins Kimmel Cancer Center uncovered clearly recognizable genetic alterations in tumors and tissue removed from patients with early-stage lung cancers that look like good predictors of which of these cancers are more likely to recur. The discovery could change the approach to treating even the smallest lung cancers – the size of a pea – which are known to recur within five years in 30 to 40 percent of patients.
Gene Markers Located for Hereditary Prostate Cancer
Researchers at the Johns Hopkins Brady Urological Institute, Wake Forest University and the Karolinska Institute in Sweden identified an array of gene markers for hereditary prostate cancer that, along with family history for the disease, appear to raise risk to more than nine times that of men without such markers. The panel, gleaned from a study of more than 4,000 Swedes, found that these markers are common and could account for nearly half of the prostate cancer cases in the study.
Stem Cells Make Bone Marrow Cancer Resistant to Treatment
Scientists at the Johns Hopkins Kimmel Cancer Center provided evidence that cancer stem cells for multiple myeloma share many properties with normal stem cells and have multiple ways of resisting chemotherapy and other treatments. The evidence may explain why the disease is so persistent, the Johns Hopkins scientists say, and pave the way for treatments that overcome the cells’ drug resistance. Multiple myeloma affects bone marrow and bone tissue.
'Swish-and-Spit' Test Accurate for Cancer
A morning gargle could someday be more than a breath freshener - it could spot head and neck cancer, say scientists at Johns Hopkins. Their new study of a mouth rinse that captures genetic signatures common to the disease holds promise for screening those at high risk, including heavy smokers and alcohol drinkers.
2007
Cause of Hereditary Lung Disease Found
Scientists at Johns Hopkins identified the genetic culprits that trigger a hereditary form of a fatal lung disease. The findings may provide new directions in diagnosis and treatment for families that inherit genes for the disease, as well as for those that develop non-inherited forms of the illness. A progressive scarring of the lungs with no effective treatment, idiopathic pulmonary fibrosis (IPF) affects approximately 50,000 Americans annually, and like some cancers often is fatal within three years.
Cancer Prevention Breakthrough
Johns Hopkins Kimmel Cancer Center scientists have provided definitive evidence that oral HPV infection, acquired through oral sex, is a stronger risk factor for oropharyngeal head and neck cancer than is combined heavy use of alcohol and tobacco. This discovery has tremendous implications for cancer prevention.
Johns Hopkins Develops Pancreas Cancer Screening Model
People with a family history of pancreas cancer now have a way to predict accurately their chance of carrying a gene for hereditary pancreas cancer and their lifetime risk of developing the disease. Developed by Johns Hopkins Kimmel Cancer Center researchers, the novel computer software tool is designed to help genetic counselors and physicians decide who would most benefit from early screening.
2006
Kimmel Cancer Center Called Research Powerhouse
Science Watch newsletter names five Kimmel Cancer Center doctors as the best in their field and the most often cited in all of cancer research worldwide.
Kimmel Cancer Center Investigators Crack Cancer Code
Kimmel Cancer Center investigators uncover the cancer genome, or blueprint, for colon and breast cancers.
U. S. News and World Report Ranks Kimmel Cancer Center Third Best in Nation
For the 15th consecutive year, U. S. News and World Report ranks the Kimmel Cancer Center as one of the top three cancer hospitals in the national. The Kimmel Cancer Center continues to be the top-ranked center in the mid-Atlantic region.
New Standard of Care
A 50-year-old method for delivering chemotherapy directly into the abdomen was reevaluated for patients with ovarian cancer after a seven-year study of more than 400 patients revealed increased survival rates in patients with advanced ovarian cancer.
Detecting Cancer Cells
Kimmel Cancer Center researchers determine that a method of screening body fluids, for certain kinds of cells and some of their genetic blueprint, is twice as accurate at spotting breast cancer cells as is a pathologist's view with a microscope.
Preventing Cancer
Sulforaphane-filled broccoli sprouts, in oral and topical form, are shown by Kimmel Cancer Center investigators to reactivate a cancer-preventing gene pathway in breast, lung, stomach, and skin cancers.
Kimmel Faculty Leaders in Cancer Care and Research
Nancy E. Davidson is elected President of the American Society of Clinical Oncology (ASCO) for a one-year term beginning in June 2007.
2005
Vaccines, A New Treatment Weapon for Cancer
Johns Hopkins Kimmel Cancer Center researchers are encouraged by early results of a treatment vaccine for pancreatic cancer, a disease with few options and low odds for long-term survival. At about two years into a study of 60 patients, the researchers report that 88 percent survived one year and 76 percent are alive after two years.
A therapeutic cervical cancer vaccine was developed and tested in women with advanced disease.
Getting Therapy Right to the Cancer
The breast ducts, or channels that produce milk and carry other secretions throughout the breast tissue, are most often where breast cancer originates. Now, Kimmel Cancer Center investigators are exploring the benefits of delivering chemotherapy directly to these ducts. Promising animal studies of this method of delivering anticancer drugs, known as intraductal chemotherapy, has led to Phase I clinical trials in women with very early breast cancer.
New Use for Statins
In a 10-year study of more than 30,000 health professionals, researchers at Johns Hopkins and Harvard found that the longer men take cholesterol-lowering drugs such as statins, the far less likely they are to develop advanced prostate cancer.
2004
Epigenetics: The Less Understood DNA Alteration
Epigenetics is the study of gene alterations that occur without mutating the DNA. Instead of mutating, genes are altered by a cellular mechanism known as methylation. Methylation of tumor suppressor genes has been shown by Kimmel Cancer Center investigators to silence them, allowing cancers to start. Demonstrating the significance of this work, the FDA recently approved the first demethylating agent, a drug that reduces methylation in genes and restores their function. In addition, our investigators have used epigenetic biomarkers to: develop screening tests for cancer; help guide surgeons in removing cancerous tumors; predict drug resistance; and, pinpoint more aggressive cancers.
Steven Baylin's epigenetics research is recognized by the National Cancer Institute as the most outstanding in its SPORE (Specialized Program of Research Excellence).
Super Oncogene Identified
Scientists at the Johns Hopkins Kimmel Cancer Center and the Howard Hughes Medical Institute have found mutations in a gene, called PIK3CA, linked to the progression of colon and other cancers. The gene is the most commonly mutated oncogene.
Blood Test Detects the Silent Cancer
Using three proteins found in common in the blood of women with ovarian disease, Kimmel Cancer Center researchers have designed a blood test to detect the disease.
Prestigious Faculty Honors
Bert Vogelstein received Spain's Prince of Asturias Award for Scientific and Technical Research. The award is considered that country's Nobel Prize.
2003
Elusive Cancer Stem Cell Identified
Johns Hopkins Kimmel Cancer Center scientists have identified the cell likely to be responsible for the development of multiple myeloma, a cancer of the bone marrow that destroys bone tissue.
Genetic Mistake Causes Most Thyroid Cancer
Kimmel Cancer Center researchers have found that a single genetic mistake in the BRAF gene causes about two-thirds of papillary thyroid cancers.
Cutting Off the Blood Supply to Tumors
Kimmel Cancer Center investigators have found antiangiogenesis agents that cut the blood supply to tumors, halting their growth and stopping the deadly invasion into other tissue and organs, thus keeping tumors in a chronic, stable phase.
Gamma Knife Center
The state-of-the art Gamma Knife Center opens, with scientists using the latest computer and robotic technology and precisely-targeted X-ray beams to perform surgery without knives on brain tumors and other brain diseases.
2002
Stool Test Detects Earliest, Curable Stage of Colon Cancer
Kimmel Cancer Center scientists have developed a safe and reliable stool test that can detect colon cancer in its earliest, curable stages. Kimmel researchers also detect a mutated APC gene in DNA found in stool.
Voice-Box Saved with New Larynx Cancer Therapy
Standard therapy changes for larynx cancer, and, the voice box is spared, after Kimmel Cancer Center investigators prove that, for most patients, combined treatment with chemotherapy and radiation has the same success rate as surgically removing the cancerous voice box.
Old Drug Leads to New Cure
Kimmel Cancer Center scientists discover that high dose cyclophosphamide, without bone marrow transplant, cures aplastic anemia and several autoimmune diseases.
Cause of Resistant Leukemia Identified
Kimmel Cancer Center investigators identify an FLT3 mutation and link it to a treatment-resistant form of acute myeloid leukemia. Drugs that target the mutation are developed and tested.
Kimmel Cancer Center cancer pain experts develop the Hopkins Opioid Program (HOP), a computer program, accessible by handheld PDAs, used to choose and prescribe correct dosages of pain killers for cancer patients.
The Sidney Kimmel Cancer Center and Howard University team up to study and develop interventions for cancer disparities among minority populations.
Kimmel Cancer Center scientists develop Digital SNP, (snip), a diagnostic blood test for ovarian cancer that identifies DNA shed from ovarian cancer cells.
Kimmel Cancer Center investigators discover relationship between well known oncogene c-myc and a newly discovered enzyme called PRDX3. PRDX3 acts like a switch, turning on c-myc and tumor cell development.
AMACR gene identified by Kimmel Cancer Center researchers as a prevention and early diagnostic marker for prostate cancer.
2001
Sidney Kimmel makes an historic $150 million donation, the single largest gift to the Johns Hopkins University, for cancer research and patient care. In his homor, the Cancer Center is renamed the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
The Kimmel Cancer Center receives more than $2 million for cancer research through the Maryland Cigarette Restitution Fund, established from awards from the multistate lawsuit against cigarette manufacturers. High minority cancer rates are a major focus of Kimmel investigators.
Kimmel Cancer Center researchers prove that high-dose cyclophosphamide therapy, administered alone (without bone marrow transplantation), is an effective therapy for many aplastic anemia patients.
ID1 gene identified by Kimmel Cancer Center scientists as an early diagnostic marker for melanoma.
Gene-based therapy targets the FLT-3 gene, the culprit in a lethal form of acute myelogenous leukemia.
New Drug Development Capitalizes on Basic Science Discoveries
Kimmel Cancer Center scientists develope drugs and compounds that block: genes altered by abnormal methylation; mutated genes; and, blood supplies to tumor cells.
A combined chemotherapy/radiation regimen created by Kimmel Cancer Center researchers saves the voice box for many laryngeal cancer patients.
Basic scientists show stem cells help repair damaged tissue and organs. Johns Hopkins researchers then study stem cell infusion as therapy for cancer treatment toxicity, diabetes, cystic fibrosis, and other diseases.
2000
Johns Hopkins Cancer Center researchers develop a pancreatic cancer vaccine and prove it activates immune cells against pancreatic tumor cells.
Cancer Center investigators uncover a genetic alteration that inhibits how brain cancer cells respond to chemotherapy. The development of drugs to block the gene's function begin.
A Cancer Center investigator becomes the first to link definitively the sexually-transmitted Human Papilloma Virus, (HPV) to the initiation of certain oral cancers.
A Cancer Center surgeon develops a breast endoscope that allows doctors to look inside breast ducts, detecting lesions 1/100 the size of those seen with MRI and mammography.
The prototype for a noninvasive screening test for cancer is developed by Cancer Center researchers. DNA from tumor cells in body fluids, such as urine, saliva, sputum, and breast lavage fluids, is detected.
Cancer Center scientists develop a conversion test that is nearly 100 percent effective in unmasking hidden gene mutations in patients with a family history of colon cancer.
1999
The opening of the Bunting Blaustein Cancer Research Building brings together more than 400 cancer researchers and staff.
1998
A saliva test that detects squamous cell head and neck cancer is developed by Kimmel Cancer Center scientists.
The Breast and Ovarian Surveillance Service (BOSS), Colon Cancer Risk Assessment Service and Familial Cancer Service are established at the Cancer Center to provide genetic counseling, testing, screening recommendations, and test prevention strategies for individuals and families at high risk of developing cancer.
The Johns Hopkins Cancer Center opens the first prostate cancer specimen bank to collect tissue, blood, and urine from prostate cancer patients in order to gain new information about the disease.
The Palliative Care Program is established.
The Pediatric Oncology Outpatient/Inpatient Unit (POP IN) opens, allowing many children, including bone marrow transplant patients, to receive their therapies as outpatients.
1997
Johns Hopkins and the National Cancer Institute (NCI) create a joint fellowship training program for Pediatric Oncology.
Construction of the $59 million, 217-square foot, Cancer Research Facility begins.
1996
Johns Hopkins Cancer Center investigators find that people who smoke have twice as many P53 mutations as those who do not. This discovery is the first definitive biologic link between smoking and cancer.
A button-sized, polymer implant is developed by Cancer Center scientists to deliver steady doses of pain medication for up the three months.
Cancer Center investigators identify the enzyme, telomerase, as a tumor marker for breast cancer.
Cancer Center researchers develop a screening test that detects bladder cancer cells in the urine.
Construction of the new $125 million, 134-bed, Comprehensive Cancer Center begins.
Polymorphisms, previously thought to be harmless, are found by Cancer Center scientists to lead to cancer. One such abnormality in the APC gene is linked to familial colon cancer.
1995
The Pediatric Bone Marrow Transplant Center opens.
The Bone Marrow Transplant IPOP Center opens. This intensive therapy is now a largely outpatient procedure.
1994
DNA replication errors, called clonal markers, are used by Johns Hopkins Cancer Center investigators to detect cancer cells in body fluids, tissues, and secretions, at the very earliest stages, before the cancer is detected by pathology.
The Cancer Center is awarded a grant from the National Cancer Institute (NCI) to launch a Comprehensive Breast Cancer program focused on clinical and basic research, prevention strategies, and the development of new therapies.
SAGE, a computerized system that allows researchers to study thousands of genes simultaneously, is developed and helps Cancer Center scientists pinpoint differences between normal and tumor cells.
Endothelin-l, a potent blood vessel constrictor linked to heart disease, is found by Kimmel Cancer Center investigators to play a role in advanced prostate cancer.
The GSTPl gene is found by Cancer Center researchers to be inactivated in prostate cells. This inactivation causes benign tumors to turn malignant.
1993
The Johns Hopkins Cancer Center is awarded a record three SPORE grants for lung, gastrointestinal, and prostate cancer research.
A class of anticancer compounds, called topoisomerase inhibitors, is shown by Cancer Center scientists to initiate antitumor responses in treatment-resistant cancers.
Cancer Center invesigators find that abnormal methylation disables tumor suppressor genes, leading to the loss of normal cell function.
Elutriation augmentation, which removes T-cells but preserves stem cells, reduces bone marrow transplant (BMT)complications and hospital stays.
The Kimmel Cancer Center becomes one of the first in the nation to use a 3-D radiation simulation for more precisely planned radiation therapy.
Cancer Center investigators discover that chemotherapy and radiation therapy administered prior to surgery improve success rates in esophageal cancer patients.
The Pediatric Oncology Long Term Survivors Program becomes one of only a handful in the country to treat, and make recommendations to prevent, long-term medical problems associated with childhood cancer therapy.
1992
A group of breast cancer survivors and concerned Maryland women raise $2.l million to fund one of the nation's first breast cancer research chairs and fellowships at Johns Hopkins.
1991
A Johns Hopkins Cancer Center Hopkins pediatric oncologist performs the first cord blood transplant for leukemia.
Programmed cell death, in which a specific, biochemical message is sent to the cancer cell, is used by Cancer Center researchers to trigger hormone-dependent breast cancer cells to die.
The National Familial Brain Tumor Registry, one of the largest collection of data on brain tumors in the world, is located in the Cancer Center and provides the first evidence that brain cancers can occur as a family disorder.
1990
Johns Hopkins Cancer Center investigators develop a blood test that identifies genetic mutations associated with an inherited form of colon cancer. This blood test, the first genetic screening test for cancer, is made available to high risk families.
Molecular markers that point to the earliest steps in the development of lung cancer are identified by Cancer Center scientists.
1989
Medical scientists at the Johns Hopkins Cancer Center perform one of the first umbilical cord blood transplants, the first in a leukemia patient.
A new drug regimen proposed by Cancer Center scientists for Acute Lymphocytic Leukemia (ALL) in children increases survival from 50 percent to 90 percent.
A new treatment, developed by Kimmel Cancer Center researchers, delivers radioactive "seeds" into the airways, extending life for inoperable lung cancer patients. The same type of therapy is now used to treat prostate cancer.
Cancer Center investigators demonstrate that topoisomerase inhibitors induce programmed cell death in leukemia cells.
Genetically-engineered tumor cells are used to supercharge the immune system to seek out and destroy cancer cells. This vaccine prototype is today being studied by Cancer Center researchers in clinical trials for kidney, prostate, and pancreatic cancers.
The P53 gene is linked by Cancer Center investigators to the progression of colon cancer, who later find this gene to be the most commonly mutated gene in all cancers. This discovery marks the beginning of a decade-long series of genetic discoveries associated with the initiation and progression of colon cancer.
1988
Johns Hopkins Cancer Center investigators find hot spots of increased DNA methylation in human cancers. These hot spots play a key role in the genetic instability of tumors.
The Hemapheresis Center now includes the unrelated bone marrow donor pool and human stem cell bank.
The Cancer Center's unrelated bone marrow donor pool produces its first match.
The Hackerman-Patz House, a home-away-from-home for patients traveling to the Cancer Center for cancer treatment, opens.
1987
Patents are awarded to Johns Hopkins for CD34 human stem cell antibodies.
Biodegradable BCNU polymer implants are approved for clinical trials, conducted by Cancer Center investigators, in brain tumor patients.
Thalidomide is used successfully by Cancer Center researchers to treat graft versus host disease.
1986
The Joanne Rockwell Memorial House, a home-away-from-home for patients traveling to the Johns Hopkins Cancer Center for cancer treatment, opens.
The Cancer Center is the only one in the region to perform stereotactic brain surgery, a computer-generated surgery, performed without knives, in order to destroy deep-seated tumors and blood vessel malformations in the brain.
Timed Sequential Therapy for leukemia results in long-term remissions for 70 perent of patients treated at the Cancer Center.
1985
The Johns Hopkins Cancer Center's nursing research program begins.
The Department of Patient and Family Services begins.
1984
Johns Hopkins Cancer Center researchers' discovery of the CD34 antibody makes it possible to isolate and collect bone marrow stem cells.
The anticancer compound paclitaxel is refined at the Cancer Center and hailed as the most promising new anticancer drug in decades. It becomes standard therapy for the treatment of ovarian cancer and shows promise in lung and breast cancer therapy.
Dual chromosome losses are linked by Cancer Center investigators to Wilm's Tumor, a childhood kidney cancer.
1982
The National Cancer Institute (NCI) selects the Johns Hopkins Cancer Center as a site for Phase l clinical trials of new anticancer drugs.
The Pediatric Neuro-oncology program begins.
1981
A Neuro-oncology study group is formed that brings together diverse specialists for patient care and basic and clinical research.
1980
The cancer cell-purging drug 4-HC is developed at the Johns Hopkins Cancer Center, making autologous (self-donor) bone marrow transplants possible.
1979
The Johns Hopkins Cancer Center is awarded a National Cancer Institute (NCI) grant for new drug development.
1978
The first Community Outreach proposal is developed to fulfill the mission of the Johns Hopkins Cancer Center to transfer laboratory discoveries to the community.
The breast lesion and evaluation program offers the first screening clinic run by nurses.
1977
The Hemapheresis Center opens at Johns Hopkins to supply platelet support for patients.
The Johns Hopkins Oncology Center opens as one of the first Comprehensive Cancer Centers under the National Cancer Act.
1976
The Cancer Information Service (CIS) opens at the Johns Hopkins Oncology Center.
The Division of Pediatric Oncology is established.
1975
The Johns Hopkins Cancer Center establishes one of the nation's first cancer pharmacology programs and begins developing and testing novel drugs and compounds for the treatment of cancer. The Cancer Center quickly earns National Cancer Institute (NCI) recognition and a grant for Phase I trials of these drugs.
1974
Construction of the existing Oncology Center begins.
The nuclear matrix is identified by Johns Hopkins Cancer Center researchers as the site for DNA replication. This discovery sheds light on the cellular changes that cause normal cells to turn malignant.
The first Diagnosis and Treatment of Neoplastic Disorders course is held.
1973
The Department of Oncology is established with just 13 faculty members. By 2003, the Cancer Center has more than 342 faculty and is a world leader in the research and treatment of cancer.
Oncology is granted departmental status at the Johns Hopkins University School of Medicine.
The University and hospital trustees authorize construction of the Johns Hopkins Oncology Center.
Johns Hopkins is designated a Comprehensive Cancer Center by the National Cancer Institute.
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