Dr. Daniel J. Leahy

Ph.D.

dleahy1@jhmi.edu

Titles

Professor, Biophysics & Biophysical Chemistry

Schools\Degrees

Ph.D., Stanford University

Training

Postdoctoral research, Structural Biology, Columbia University

Research Summary

Dr. Leahy's research is focused on understanding the molecular mechanisms of signal transduction and oncogenic activation in the Hedgehog and ErbB signalng pathways.

Journal Citations

Kavran, J.M., Ward, M.D., Oladosu, O.O., Mulepati, S., and Leahy, D.J. "All Mammalian Hedgehog Proteins Interact with Cell-Adhesion Molecule, Down-regulated by Oncogenes (CDO) and Brother of CDO (BOC) in a Conserved Manner." (2010) J. Biol. Chem., in press.

Williams E.H., Pappano W.N., Saunders A.M., Kim M.-S., Leahy D.J., and Beachy P.A. "Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response." Proc. Natl. Acad. Sci. USA (2010) 107(13):5869-74.

Qiu, C., Tarrant, M.K., Boronina, T., Longo, P.A., Kavran, J.M., Cole, R.M., Cole, P.A., and Leahy, D.J. "In Vitro Enzymatic Characterization of Near Full Length EGFR in Activated and Inhibited States." Biochemistry (2009) 48:6624-6632.

McLellan, J.S., Zheng, X., Hauk, G., Ghirlando, R., Beachy, P.A., and Leahy, D.J. "The mode of Hedgehog binding to Ihog homologs is not conserved across different phyla" Nature (2008) Oct 16; 455:979-983.

Leahy, D.J. "A Molecular View of Anti-ErbB Monoclonal Antibody Therapy." Cancer Cell Volume 13, Issue 4, 8 April 2008, Pages 291-293

Qiu, C., Tarrant, M.K., Choi, S.H., Sathyamurthy, A., Bose, R., Banjade, S., Pal, A., Bornmann, W.G., Lemmon, M.A., Cole, P.A., and Leahy, D.J. "Mechanism of activation and inhibition of the HER4/ErbB4 kinase." Structure (2008) Mar;16(3):460-7.

Suh, Y., Atzmon, G., Cho, M.-O., Hwang, D., Liu, B., Leahy, D.J., Barzilai, N., and Cohen, P. "Functionally significant insulin-like growth factor I receptor mutations in centenarians." Proc. Natl. Acad. Sci. USA (2008) Mar 4;105(9):3438-42.