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Dr. Yanxing Yu

M.D., Ph.D., M.S.
Yanxing Yu

Viral Oncology


Research Associate, Oncology


M.D., 1981 PLA Medical School, China M.S. 1992 PLA Graduate Medical School, China Microbiology Ph.D. 1995 Institute of Radiation Medicine,Microbiology, Academy of Military Medical Science, China.


Postdoc 1996-1998 Unité de Virologie & Immunuologie Moléculaires Virology & Immunology, Centre de Recherches de Jouy-en-Josas Institut National de la Recherche Agronomique, Paris.

Postdoc 1998-2001 Virology & Immunology Laboratory, Virology & Immunology Pharmacology & Experimental therapeutics. University of Maryland, School of Medicine, Baltimore, MD.

Postdoc 2001-2004 Department of Oncology, Molecular Virology Viral Oncology Laboratories, The Johns Hopkins University School of Medicine, Baltimore, MD.

Journal Citations

Yu YX, Jiang YY, Song SB. Idiopathic Retroperitoneal Fibrosis Report of Five Casesand Review of the Literature. J. Practical Surgery. 1991. 11(6): 313-315.

Yu YX, Zhang GH. The Glucagonoma Syndrome. J. Practical Surgery. 1993. 13(2):117-119.

Yu YX, Zhang GH. Fourteen case of Riedel's struma: Review of the literature. Chung Hua Wai Ko Tsa Chih, 1993; 31(4):226-228.

Yu YX, Li YM, Yuan M. Adoptive Immunotherapy of Tumor infiltrating Lymphocyte. J. of Hepatobiliary, Pancreatic and Spleenic Surgery.1995;1(3):204-205.

Yu YX, Yuan M, Li YM. Genetically Engineered Antibodies and Antibody-Targeted Interleukin-2 Fusion Protein. Chin J Cancer Biother. 1996. 3(3):240-243.

Yu YX, Gu ZY. A New Model Of AHNP For Intraductal Administration In Rat. Chin J Experimental Surgery, 1996; 13(5):261-262.

Yu YX, Yuan M, Li YM and Mao L. Expression And Characterization Of A Fusion Protein Consisting Of A Human IL-2 And Scfv Directed Against Adenocarcinomas In E.Coli. High Technology Bulletin, 1997; 3(1):101-105.

Zheng W, Tan H, Song SB, Hao LY, Wang Y, Yin R and Yu YX. The Construction Of Expression Vector For Anti-Hbsag Fab Fragment And Interferon-Aa Fusion Protein in E.coli. Acad J PLA Med Sch. 1998; 19(3): 161-163.

Zheng W, Tan H, Shong SB, Hao LY, Wang Y, Yu YX, Yin R. The Construction And Expression of A Fusion Protein Consisting of Anti-Hbsag Antibody Fragment Fab and Interferon-aA in E.coli. Clin J. Hepatol. 1998; 6(4):229-231.

Yu YX, Bearzotti M, Vende P, Ahne W, Bremont M. Partial Mapping and Sequencing of A Fish Iridovirus Genome Reveals Genes Homologous to the Frog Virus 3 p31, p40 and Human eIF2alpha. Virus Res. 1999; 63(1-2):53-63.

Biacchesi S, Yu YX, Bearzotti M, Tafalla C, Fernandez-Alonso M, Bremont M. Rescue of Synthetic Salmonid Rhabdovirus Minigenomes. J Gen Virol. 2000;81(Pt 8):1941-1945.

Smith CC, Yu YX, Kulka M, Aurelian L. A Novel Human Gene Similar to the Protein Kinase (Pk) Coding Domain of the Large Subunit of Herpes Simplex Virus Type 2 Ribonucleotide Reductase (Icp10) Codes For A Serine-Threonine Pk and is Expressed in Melanoma Cell. J Biol Chem. 2000; 275(33):25690-9.

Biacchesi S, Thoulouze M.I, Béarzotti M, Yu YX and Brémont M. Recovery of NV Knockout Infectious Hematopoietic Necrosis Virus Expressing Foreign Genes. J.Virol 2000. 74(23):11247-11252.

Yu YX, Heller A, Liehr T and Aurelian L. A Novel Gene Associated With Human Melanoma (H11) is Abundantly Expressed in Muscle and Spinal Cord and Maps to Chromosome 12q24.1-12q24.31.Int J Oncol. 2001;18(5):905-11.

Perkins D, Yu Y, Bambrick LL, Yarowsky PJ, Aurelian L. Expression of Herpes Simplex Virus Type 2 Protein ICP10 PK Rescues Neurons From Apoptosis Due To Serum Deprivation Or Genetic Defects. Exp Neurol. 2002;174(1):118-22

Poole LJ, Yu Y, Kim PS, Zheng QZ, Pevsner J, Hayward GS. Altered Patterns of Cellular Gene Expression in Dermal Microvascular Endothelial Cells Infected with Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2002;76(7):3395-420.

Wang SE, Wu FY, Yu Y, Hayward GS. CCAAT/enhancer-binding Protein-Alpha Is Induced During The Early Stages Of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Lytic Cycle Reactivation And Together With The KSHV Replication And Transcription Activator (RTA) Cooperatively Stimulates The Viral RTA, MTA, and PAN Promoters. J Virol. 2003; 77(17):9590-612.

Yu, Y, Wang, S.E.and Hayward, G.S. The KSHV Immediate-Early Transcription Factor RTA Encodes Ubiquitin E3 Ligase Activity that Targets IRF7 for Proteosome-Mediated Degradation. Immunity. 2005; 22: 59-70


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