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Dr. Peng Huang

Peng Huang

Associate Professor of Oncology Biostatistics
Division of Oncology Biostatistics, Department of Oncology, School of Medicine, Johns Hopkins University
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins


Ph.D., Statistics, University of Rochester MA, Statistics, University of Rochester MS, Statistical Quality Control, Rochester Institute of Technology

Research Summary

Dr. Huang’s research mainly focuses on global assessment of treatment effect when multiple endpoints are evaluated simultaneously. This includes optimal study design with multiple endpoints, sequential clinical trial data monitory, and final data analysis of multiple endpoints. Dr. Huang has received NIH research grant award in the development of global statistical test. She won the 1997 Shewell Award from American Society for Quality Control for her innovative minimum aberration split-plot design which has been adopted into the widely used SAS software.

At Johns Hopkins University, Dr. Huang’s main role is to provide biostatistics support in study design and data analysis. She is a full member of Clinical Research Review Committee at The Sidney Kimmel Comprehensive Cancer Center, the leading biostatistician in breast cancer, liver cancer, and imaging studies. Dr. Huang has extensive experiences in statistical design and data analysis for clinical trials and lab experiments. Outside Johns Hopkins, Dr. Huang serves in multiple NIH/CSR and NIH/NCI study section review panels since 2002. Currently, Dr. Huang is a member of NIH/CSR Clinical Neuroscience and Disease (CNN) Study Section (a six-year appointment).

Journal Citations

Huang P, Chen D, Voelkel JO, Minimum aberration two-level split plot design. Technometrics 1998; 40(4): 314-326.
Huang P, Dragalin V, Hall WJ, Asymptotic solution to the kiefer-weiss problem for brownian motion with symmetric triangular stopping boundaries. Sequential Analysis 2000; 19:143-160.

Huang P, Existence of a minimax group sequential test. Sequential Analysis 2000; 19:93-204.

Yakir B, Huang P, Hall WJ, Completeness for brownian motion with piecewise linear stopping boundaries. Sequential Analysis 2001; 20(3):201-208.

Huang P. Asymptotic design for Brownian motion with general triangular stopping boundaries. IMS Lecture Notes -- Monograph Series, Crossing Boundaries: Statistical Essays in Honor of Jack Hall J. Kolassa and D. Oakes (editors), 2003; 43:29-46.

Chen D, Huang P, Cheng X, A concrete statistical realization of Kleinberg's stochastic discrimination for pattern recognition, Part I. Two-class classification. Annals of Statistics 2003; 31:1393-1412.

Huang P., Tilley B, Woolson R, and Lipsitz S, Adjusting O'Brien's test to control type I error for the generalized nonparametric Behrens-Fisher problem. Biometrics 2005; 61:532-539.

The NINDS NET-PD Investigators. A Randomized, Double Blinded, Futility clinical trial of creatine and minocycline in early parkinson's disease. Neurology 2006; 66:664-671.

The NINDS NET-PD Investigators. A Randomized Clinical Trial of Coenzyme Q10 and GPI-1485 in Early Parkinson's Disease. Neurology 2007; 68:20-28.

Wilcox S, Laken M, Bopp M, Gethers O, Huang P, McClorin L, Parrott AW, Swinton R, Yancey A. Increasing physical activity among church members: community-based participatory research. Am J Prev Med. 2007;32(2):131-8.

Huang P, Woolson RF, O'Brien PC. A rank-based sample size method for multiple outcomes in clinical trials. Statistics in Medicine. 2008; 27(16):3084-3104.

The NINDA NET-PD Investigators. A pilot clinical trial of creatine and minocycline in early Parkinson disease: 18-month results. Clin Neuropharmacol. 2008;31(3):141-150. PMCID: PMC2891220

Huang P., Woolson RF., Granholm A. The use of a global statistical approach for the design and data analysis of clinical trials with multiple primary outcomes, Experimental Stroke 2009;1:100-109. "not supported through NIH funding"

Huang P, Goetz CG, Woolson RF, Tilley B, Kerr D, Palesch Y, Elm J, Ravina B, Bergmann KJ, Kieburtz K; Parkinson Study Group. Using global statistical tests in long-term Parkinson's disease clinical trials. Mov Disord. 2009;24(12):1732-9. PMCID: PMC2813508

Huang P., Chen M-H, Sinha D. A latent model approach to define event onset time in the presence of measurement error. Statistics and its Interface. 2009; 2:425-435 PMCID: PMC299605

Schaefer NG, Ma J, Huang P, Buchanan J, Wahl RL. Radioimmunotherapy in non-Hodgkin lymphoma: opinions of U.S. medical oncologists and hematologists. J Nucl Med. 2010;51(6):987-94. "not supported through NIH funding"

Demokan S, Chang X, Chuang A, Mydlarz WK, Kaur J, Huang P, Khan Z, Khan T, Ostrow KL, Brait M, Hoque MO, Liegeois NJ, Sidransky D, Koch W, Califano JA. KIF1A and EDNRB are differentially methylated in primary HNSCC and salivary rinses. International Journal of Cancer. 2010. Vol 127(10): 2351-2359 "not supported through NIH funding"

Khouli R, Jacobs M, Mezban S, Huang P, Kamel I, Macura K, Bluemke D. Diffusion-weighted imaging improves the diagnostic accuracy of conventional 3.0-T breast MR imaging, Radiology 2010. 256: 64-73. PMCID: PMC2897691

Yu F, Chen MH, Kuo L, Huang P, Yang W. Bayesian Hierarchical Modeling for Detecting DE Genes from the EST Data. Biometrics. 2011. 67, 142-150.

Cerutti J. Oler G, Delcelo R, Gerardt R, Michaluart P, Souza S, Galante P, Huang P, Riggins G. PVALB, a new Hürthle adenoma marker identified through gene expression profiling improves diagnostic accuracy of a thyroid nodule. J Clin Endocrinol Metab. 2011. 96(1). Doi:10.1210/jc.2010-1318 http://jcem.endojournals.org/cgi/rapidpdf/jc.2010-1318v1

Keizman D, Huang P, Antonarakis ES, Sinibaldi V, Carducci MA, Denmeade S, Kim JJ, Walczak J, Eisenberger MA. The change of PSA doubling time and its association with disease progression in patients with biochemically relapsed prostate cancer treated with intermittent androgen Deprivation. Prostate. 2011 Mar 22. 71:1608-1615. PMC393222.

Keizman D, Huang P, Eisenberger MA, Pili R, Kim J, Hammers H, Carducci MA. Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: A retrospective examination. European Journal of Cancer. 2011 September; 47(13): 1955-1961. PMC393247.

Schaefer NG, Huang P, Buchanan J, Wahl RL. Radioimmunotherapy in Non-Hodgkin Lymphoma: Opinions of Nuclear Medicine Physicians and Radiation Oncologists. J Nucl Med. 2011;52:830-838. "not supported through NIH funding"

Fackler MJ, Umbricht C, Williams D, Argani P, Cruz L, Merino V, Teo W, Zhang Z, Huang P, Visvananthan K, Marks J, Ethier S, Gray J, Wolff A, Cope L, Sukumar S. Genome-wide methylation analysis identifies genes specific to breast cancer hormone receptor status and risk of recurrence. Cancer Research. 2011; 1;71(19):6195-207.

Keizman D, Ish-Shalom M, Huang P, Eisenberger MA, Pili R, Kim J, Hammers H, Carducci MA. The association of pre-treatment neutrophil to lymphocyte ratio with response rate, progression free survival, and overall survival of patients treated with sunitinib for metastatic renal cell carcinoma. European Journal of Cancer. 2012; 48:202-208.

Higgins M, Jelovac D, Barnathan E, Blair B, SlaterS, Powers P, Zorzi J, Jeter S, Oliver G, Fetting J, Emens L, Riley C, Stearns V, Diehl F, Angenendt P, Huang P, Cope L, Argani P, Murphy K, Bachman K, Greshock J, Wolff A, and Park B. Detection of tumor PIK3CA status in Metastatic Breast Cancer using Peripheral Blood. Clinical Cancer Research. 2012; 18:3462-3469.

Goyal J. Nuhn P, Huang P, Tyagi P, Oh D, Carducci MA, Eisenberger MA, Antonarakis, E. The effect of clinical trial participation versus non-participation on overall survival in men receiving first-line docetaxel-containing chemotherapy for metastatic castration-resistant prostate cancer. British Journal of Urology International To appear.


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