Dr. Kiyoshi Yoshimura

M.D., Ph.D.

Titles

Assistant Professor, Department of Surgery and Oncology

Schools\Degrees

M.D., Yamaguchi University, School of Medicine Ph.D.,Yamaguchi University, School of Medicine

Training

Junior Resident, Department of Surgery, Iwakuni Medical Center HospitalSenior Resident-Fellowship, Department of Surgery, Onoda Red Cross Hospital.Fellowship, Department of Surgery II, Yamaguchi University HospitalPostdoctoral fellow, Johns Hopkins University, School of Medicine, Department of Oncology, Division of Immunology and Hematopoiesis

Journal Citations

Anand, S., Wang, P., Yoshimura, K., Choi, I. H., Hilliard, A., Chen, Y. H., Wang, C. R., Schulick, R., Flies, A. S., Flies, D. B., Zhu, G., Xu, Y., Pardoll, D. M., Chen, L. & Tamada, K. (2006). Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. J Clin Invest 116, 1045-51.

Brody, J. R., Gallmeier, E., Yoshimura, K., Hucl, T., Kulesza, P., Canto, M. I., Hruban, R. H., Schulick, R. D. & Kern, S. E. (2006). A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymidylate synthase ternary complexes. Cancer Biol Ther 5, 923-7.

Chan, C. W., Crafton, E., Fan, H. N., Flook, J., Yoshimura, K., Skarica, M., Brockstedt, D., Dubensky, T. W., Stins, M. F., Lanier, L. L., Pardoll, D. M. & Housseau, F. (2006). Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat Med 12, 207-13.

Miyashita, T., Shah, F.A., Marti, G., Wang, J., Armstrong, T., Bonde, P., Gibson, M.K., Yoshimura, K., Montgomery, E.A., Duncan, M.D., Jaffee, E.M., and Harmon, J.W. (2008). Vaccine impedes the development of reflux-induced esophageal cancer in a surgical rat model: efficacy of the vaccine in a Pre-Barrett's esophagus setting. J Gastrointest Surg 12, 2-7; discussion 7-9.

Miyashita, T., Shah, F.A., Marti, G.P., Armstrong, T.D., Wang, J., Bonde, P., Gibson, M.K., Yoshimura, K., Montgomery, E.A., Duncan, M., Jaffee, E.M., and Harmon, J.W. (2008). Vaccine impedes the development of reflux-induced esophageal cancer in a surgical rat model: efficacy of the vaccine in a post-Barrett's esophagus setting. Dig Dis Sci 53, 2858-2867.

Ravi, R., Fuchs, E. J., Jain, A., Pham, V., Yoshimura, K., Prouser, T., Jalla, S., Zhou, X., Garrett-Mayer, E., Kaufmann, S. H., Schulick, R. D., Pardoll, D. M. & Bedi, A. (2006). Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling. Cancer Res 66, 1730-9.

Yoshimura, K., Jain, A., Allen, H. E., Laird, L. S., Chia, C. Y., Ravi, S., Brockstedt, D. G., Giedlin, M. A., Bahjat, K. S., Leong, M. L., Slansky, J. E., Cook, D. N., Dubensky, T. W., Pardoll, D. M. & Schulick, R. D. (2006). Selective targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenes. Cancer Res 66, 1096-104.

Yoshimura, K., L. S. Laird, C. Y. Chia, K. F. Meckel, J. E. Slansky, J. M. Thompson, A. Jain, D. M. Pardoll, and R. D. Schulick. 2007. Live attenuated Listeria monocytogenes effectively treats hepatic colorectal cancer metastases and is strongly enhanced by depletion of regulatory T cells. Cancer Res 67:10058-66.

Yoshimura K., Jain A. , Allen H.E., Laird L.S., Chia, C.Y., Ravi S., Brockstedt D.G., Giedlin M.A., Bahjat K.S., Leong M.L., Slansky J.E., Cook D.N.,. Dubensky T.W, Pardoll D.M., and Schulick R.D., Selective targeting of anti-tumor immune responses with engineered live-attenuated Listeria monocytogenes. Cancer Research 66(2):1096-104, 2006.

Chan, C. W., Crafton, E., Fan, H. N., Flook, J., Yoshimura, K., Skarica, M., Brockstedt, D., Dubensky, T. W., Stins, M. F., Lanier, L. L., Pardoll, D. M., and Housseau, F. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat Med, 12: 207-213, 2006.

Ravi, R., Fuchs, E. J., Jain, A., Pham, V., Yoshimura, K., Prouser, T., Jalla, S., Zhou, X., Garrett-Mayer, E., Kaufmann, S. H., Schulick, R. D., Pardoll, D. M., and Bedi, A. Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling. Cancer Res, 66: 1730-1739, 2006.

Anand, S., Wang, P., Yoshimura, K., Choi, I. H., Hilliard, A., Chen, Y. H., Wang, C. R., Schulick, R., Flies, A. S., Flies, D. B., Zhu, G., Xu, Y., Pardoll, D. M., Chen, L., and Tamada, K. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. J Clin Invest, 116: 1045-1051, 2006.

Brody, J.R., Gallmeier, E., Yoshimura, K., Hucl, T., Kulesza, P., Canto, M.I., Hruban, R.H., Schulick, R D. & Kern, S.E. A Proposed Clinical Test for Monitoring Fluoropyrimidine Therapy: Detection and Stability of Thymidylate Synthase Ternary Complexes. Cancer Biol Ther. 2006 Aug 2;5(8)

Yoshimura K., Laird L.S., Chia C.Y., Tsunedomi R., Harada T., Iizuka N., Hazama S., Oka M., Keller J.W., Meckel K.F., Thompson J.M., Park J, Jain A., Iacobuzio-Donahue C., Pardoll D.M., Schulick R.D., Integrin alpha2 mediates selective metastasis to the liver (Submitting).

Yoshimura K., Laird L.S., Chia C.Y., Meckel K.F., Slansky J.E., Thompson J.M., Jain A., Pardoll D.M., Schulick R.D., Live Attenuated Listeria monocytogenes Effectively Treats Hepatic Colorectal Cancer Metastases and is Strongly Enhanced by Depletion of Regulatory T Cells (Submitting).Kato Y, Yoshimura K, Shin T, Verheul H, Hammers H, Sanni TB, Salumbides BC, Erp KV, Schulick R, Pili R. Synergistic in vivo antitumor effect of the histone deacetylase inhibitor MS-275 in combination with interleukin 2 in a murine model of renal cell carcinoma. Accepted to Clinical Cancer Research.