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Philip Cole

M.D., Ph.D.
410-614-8849 (p)
Interests

Pharmacology

Titles

Professor
Pharmacology and Molecular Sciences

Research Summary

Our lab studies the mechanisms of cell signaling and gene regulation using a series of chemical and biochemical approaches. We study the structure, function, and regulation of protein kinases and phosphatases by post-translational modification. In this regard, we have developed a series of technologies including expressed protein ligation, chemical rescue of mutant enzymes, and bisubstrate analog inhibitors that we apply to the analysis of signaling proteins that help clarify substrate selectivity, activation state, and function. Our lab also studies histone acetyltransferases and demethylases and how they contribute to the regulation of gene expression and signaling. We have designed a series of selective inhibitors of these enzymes as tools for pharmacologic research. We employ and develop novel protein chemistry and proteomics methods including mass spectrometry to analyze the function of signaling enzymes on a broad scale. In addition, we are studying the mechanism and function of acyltransferases involved in circadian rhythm and metabolism using chemical biology strategies. 

 

Journal Citations

Bose, R.; Holbert, M.A.; Pickin, K.A.; Cole, P.A. Protein tyrosine kinase-substrate interactions. Current opinion in structural biology. 2006 Dec;16(6):668-675.
Bose, R.; Molina, H.; Patterson, A.S.; Bitok, J.K.; Periaswamy, B.; Bader, J.S.; Pandey, A.; Cole, P.A. Phosphoproteomic analysis of Her2/neu signaling and inhibition. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9773-9778.
Carducci, M.A.; Musib, L.; Kies, M.S.; Pili, R.; Truong, M.; Brahmer, J.R.; Cole, P.; Sullivan, R.; Riddle, J.; Schmidt, J.; Enas, N.; Sinha, V.; Thornton, D.E.; Herbst, R.S. Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer. J Clin Oncol. 2006 Sep 1;24(25):4092-4099.
Cheng, K.Y.; Noble, M.E.; Skamnaki, V.; Brown, N.R.; Lowe, E.D.; Kontogiannis, L.; Shen, K.; Cole, P.A.; Siligardi, G.; Johnson, L.N. The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition. J Biol Chem. 2006 Aug 11;281(32):23167-23179.
Culhane, J.C.; Szewczuk, L.M.; Liu, X.; Da, G.; Marmorstein, R.; Cole, P.A. A mechanism-based inactivator for histone demethylase LSD1. J Am Chem Soc. 2006 Apr 12;128(14):4536-4537.
Hunter, C.; Smith, R.; Cahill, D.P.; Stephens, P.; Stevens, C.; Teague, J.; Greenman, C.; Edkins, S.; Bignell, G.; Davies, H.; O'Meara, S.; Parker, A.; Avis, T.; Barthorpe, S.; Brackenbury, L.; Buck, G.; Butler, A.; Clements, J.; Cole, J.; Dicks, E.; Forbes, S.; Gorton, M.; Gray, K.; Halliday, K.; Harrison, R.; Hills, K.; Hinton, J.; Jenkinson, A.; Jones, D.; Kosmidou, V.; Laman, R.; Lugg, R.; Menzies, A.; Perry, J.; Petty, R.; Raine, K.; Richardson, D.; Shepherd, R.; Small, A.; Solomon, H.; Tofts, C.; Varian, J.; West, S.; Widaa, S.; Yates, A.; Easton, D.F.; Riggins, G.; Roy, J.E.; Levine, K.K.; Mueller, W.; Batchelor, T.T.; Louis, D.N.; Stratton, M.R.; Futreal, P.A.; Wooster, R. A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res. 2006 Apr 15;66(8):3987-3991.
Karanam, B.; Jiang, L.; Wang, L.; Kelleher, N.L.; Cole, P.A. Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation. J Biol Chem. 2006 Dec 29;281(52):40292-40301.
Levinson, N.M.; Kuchment, O.; Shen, K.; Young, M.A.; Koldobskiy, M.; Karplus, M.; Cole, P.A.; Kuriyan, J. A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol. 2006 May;4(5):e144.
Levy, B.A.; Vogt, K.J.; Herrera, D.A.; Cole, P.A. Maisonneuve fracture equivalent with proximal tibiofibular dislocation. A case report and literature review. The Journal of bone and joint surgery. 2006 May;88(5):1111-1116.
Sutcliffe, S.; Zenilman, J.M.; Ghanem, K.G.; Jadack, R.A.; Sokoll, L.J.; Elliott, D.J.; Nelson, W.G.; De Marzo, A.M.; Cole, S.R.; Isaacs, W.B.; Platz, E.A. Sexually transmitted infections and prostatic inflammation/cell damage as measured by serum prostate specific antigen concentration. J Urol. 2006 May;175(5):1937-1942.
Anderson, T.J.; Tchernyshyov, I.; Diez, R.; Cole, R.N.; Geman, D.; Dang, C.V.; Winslow, R.L. Discovering robust protein biomarkers for disease from relative expression reversals in 2-D DIGE data. Proteomics. 2007 Apr;7(8):1197-1207.
Cole, P.A. Chemical Biology and Enzymology, Protein Phosphorylation as a Case Study. In: Schreiber, K., Wess, editor, Chemical Biology. Weinheim: Wiley-CVH; 2007.
Hu, X.; Dang, Y.; Tenney, K.; Crews, P.; Tsai, C.W.; Sixt, K.M.; Cole, P.A.; Liu, J.O. Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem Biol. 2007 Jul;14(7):764-774.
Hwang, Y.; Ganguly, S.; Ho, A.K.; Klein, D.C.; Cole, P.A. Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug. Bioorganic & medicinal chemistry. 2007 Mar 1;15(5):2147-2155.
Hwang, Y.; Thompson, P.R.; Wang, L.; Jiang, L.; Kelleher, N.L.; Cole, P.A. A selective chemical probe for coenzyme A-requiring enzymes. Angewandte Chemie (International ed. 2007;46(40):7621-7624.
Karanam, B.; Wang, L.; Wang, D.; Liu, X.; Marmorstein, R.; Cotter, R.; Cole, P.A. Multiple roles for acetylation in the interaction of p300 HAT with ATF-2. Biochemistry. 2007 Jul 17;46(28):8207-8216.
Karp, J.E.; Smith, B.D.; Levis, M.J.; Gore, S.D.; Greer, J.; Hattenburg, C.; Briel, J.; Jones, R.J.; Wright, J.J.; Colevas, A.D. Sequential flavopiridol, cytosine arabinoside, and mitoxantrone: a phase II trial in adults with poor-risk acute myelogenous leukemia. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4467-4473.
Kenneth, N.S.; Ramsbottom, B.A.; Gomez-Roman, N.; Marshall, L.; Cole, P.A.; White, R.J. TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14917-14922.
Messersmith, W.A.; Rudek, M.A.; Baker, S.D.; Zhao, M.; Collins, C.; Colevas, A.D.; Donehower, R.C.; Carducci, M.A.; Wolff, A.C. Phase I study of continuous weekly dosing of dimethylamino benzoylphenylurea (BPU) in patients with solid tumours. Eur J Cancer. 2007 Jan;43(1):78-86.
Muratore, K.E.; Cole, P.A. A lock on phosphotyrosine signaling. ACS chemical biology. 2007 Jul 20;2(7):454-456.
Nabors, L.B.; Mikkelsen, T.; Rosenfeld, S.S.; Hochberg, F.; Akella, N.S.; Fisher, J.D.; Cloud, G.A.; Zhang, Y.; Carson, K.; Wittemer, S.M.; Colevas, A.D.; Grossman, S.A. Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007 May 1;25(13):1651-1657.
Szewczuk, L.M.; Culhane, J.C.; Yang, M.; Majumdar, A.; Yu, H.; Cole, P.A. Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. Biochemistry. 2007 Jun 12;46(23):6892-6902.
Szewczuk, L.M.; Saldanha, S.A.; Ganguly, S.; Bowers, E.M.; Javoroncov, M.; Karanam, B.; Culhane, J.C.; Holbert, M.A.; Klein, D.C.; Abagyan, R.; Cole, P.A. De novo discovery of serotonin N-acetyltransferase inhibitors. J Med Chem. 2007 Nov 1;50(22):5330-5338.
Yang, M.; Culhane, J.C.; Szewczuk, L.M.; Gocke, C.B.; Brautigam, C.A.; Tomchick, D.R.; Machius, M.; Cole, P.A.; Yu, H. Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nature structural & molecular biology. 2007 Jun;14(6):535-539.
Yang, M.; Culhane, J.C.; Szewczuk, L.M.; Jalili, P.; Ball, H.L.; Machius, M.; Cole, P.A.; Yu, H. Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry. 2007 Jul 10;46(27):8058-8065.
Zhang, X.; Pickin, K.A.; Bose, R.; Jura, N.; Cole, P.A.; Kuriyan, J. Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature. 2007 Nov 29;450(7170):741-744.
Chaerkady, R.; Harsha, H.C.; Nalli, A.; Gucek, M.; Vivekanandan, P.; Akhtar, J.; Cole, R.N.; Simmers, J.; Schulick, R.D.; Singh, S.; Torbenson, M.; Pandey, A.; Thuluvath, P.J. A quantitative proteomic approach for identification of potential biomarkers in hepatocellular carcinoma. J Proteome Res. 2008 Oct;7(10):4289-4298.
Cole, P.A. Chemical probes for histone-modifying enzymes. Nat Chem Biol. 2008 Oct;4(10):590-597.
Forastiere, A.A.; Ang, K.K.; Brizel, D.; Brockstein, B.E.; Burtness, B.A.; Cmelak, A.J.; Colevas, A.D.; Dunphy, F.; Eisele, D.W.; Goepfert, H.; Hicks, W.L., Jr.; Kies, M.S.; Lydiatt, W.M.; Maghami, E.; Martins, R.; McCaffrey, T.; Mittal, B.B.; Pfister, D.G.; Pinto, H.A.; Posner, M.R.; Ridge, J.A.; Samant, S.; Schuller, D.E.; Shah, J.P.; Spencer, S.; Trotti, A., 3rd; Weber, R.S.; Wolf, G.T.; Worden, F. Head and neck cancers. J Natl Compr Canc Netw. 2008 Aug;6(7):646-695.
Lane, Z.; Epstein, J.I.; Ayub, S.; Netto, G.J. Prostatic adenocarcinoma in colorectal biopsy: clinical and pathologic features. Hum Pathol. 2008 Apr;39(4):543-549.
Levinson, N.M.; Seeliger, M.A.; Cole, P.A.; Kuriyan, J. Structural basis for the recognition of c-Src by its inactivator Csk. Cell. 2008 Jul 11;134(1):124-134.
Liu, X.; Wang, L.; Zhao, K.; Thompson, P.R.; Hwang, Y.; Marmorstein, R.; Cole, P.A. The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature. 2008 Feb 14;451(7180):846-850.
Nguyen, G.C.; Tuskey, A.; Bayless, T.M.; LaVeist, T.A.; Brant, S.R. Community-based health preferences for proctocolectomy: a race comparison. Dig Dis Sci. 2008 Mar;53(3):741-746.
Qiu, C.; Tarrant, M.K.; Choi, S.H.; Sathyamurthy, A.; Bose, R.; Banjade, S.; Pal, A.; Bornmann, W.G.; Lemmon, M.A.; Cole, P.A.; Leahy, D.J. Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure. 2008 Mar;16(3):460-467.
Szewczuk, L.M.; Tarrant, M.K.; Sample, V.; Drury, W.J., 3rd; Zhang, J.; Cole, P.A. Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis. Biochemistry. 2008 Sep 30;47(39):10407-10419.
Tang, Y.; Holbert, M.A.; Wurtele, H.; Meeth, K.; Rocha, W.; Gharib, M.; Jiang, E.; Thibault, P.; Verrault, A.; Cole, P.A.; Marmorstein, R. Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP. Nature structural & molecular biology. 2008 Jul;15(7):738-745.
Wang, L.; Tang, Y.; Cole, P.A.; Marmorstein, R. Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. Current opinion in structural biology. 2008 Dec;18(6):741-747.
Amanchy, R.; Zhong, J.; Hong, R.; Kim, J.H.; Gucek, M.; Cole, R.N.; Molina, H.; Pandey, A. Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signaling. Mol Oncol. 2009 Dec;3(5-6):439-450.
Hansson, M.L.; Popko-Scibor, A.E.; Saint Just Ribeiro, M.; Dancy, B.M.; Lindberg, M.J.; Cole, P.A.; Wallberg, A.E. The transcriptional coactivator MAML1 regulates p300 autoacetylation and HAT activity. Nucleic Acids Res. 2009 May;37(9):2996-3006.
Herrera, D.A.; Anavian, J.; Tarkin, I.S.; Armitage, B.A.; Schroder, L.K.; Cole, P.A. Delayed operative management of fractures of the scapula. The Journal of bone and joint surgery. 2009 May;91(5):619-626.
Kamat, A.A.; Coffey, D.; Merritt, W.M.; Nugent, E.; Urbauer, D.; Lin, Y.G.; Edwards, C.; Broaddus, R.; Coleman, R.L.; Sood, A.K. EphA2 overexpression is associated with lack of hormone receptor expression and poor outcome in endometrial cancer. Cancer. 2009 Jun 15;115(12):2684-2692.
Lin, J.; Denmeade, S.; Carducci, M.A. HIF-1alpha and calcium signaling as targets for treatment of prostate cancer by cardiac glycosides. Current cancer drug targets. 2009 Nov;9(7):881-887.
Marek, D.J.; Sechriest, V.F., 2nd; Swiontkowski, M.F.; Cole, P.A. Case report: reconstruction of a recalcitrant scapular neck nonunion and literature review. Clin Orthop Relat Res. 2009 May;467(5):1370-1376.
Muratore, K.E.; Seeliger, M.A.; Wang, Z.; Fomina, D.; Neiswinger, J.; Havranek, J.J.; Baker, D.; Kuriyan, J.; Cole, P.A. Comparative analysis of mutant tyrosine kinase chemical rescue. Biochemistry. 2009 Apr 21;48(15):3378-3386.
Qiu, C.; Tarrant, M.K.; Boronina, T.; Longo, P.A.; Kavran, J.M.; Cole, R.N.; Cole, P.A.; Leahy, D.J. In vitro enzymatic characterization of near full length EGFR in activated and inhibited states. Biochemistry. 2009 Jul 21;48(28):6624-6632.
Rudin, C.M.; Hann, C.L.; Laterra, J.; Yauch, R.L.; Callahan, C.A.; Fu, L.; Holcomb, T.; Stinson, J.; Gould, S.E.; Coleman, B.; LoRusso, P.M.; Von Hoff, D.D.; de Sauvage, F.J.; Low, J.A. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. The New England journal of medicine. 2009 Sep 17;361(12):1173-1178.
Shiu, C.; Cunningham, C.K.; Greenough, T.; Muresan, P.; Sanchez-Merino, V.; Carey, V.; Jackson, J.B.; Ziemniak, C.; Fox, L.; Belzer, M.; Ray, S.C.; Luzuriaga, K.; Persaud, D.; Pediatric, A.C.T.G.P.T. Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy. J Virol. 2009 Oct;83(19):9731-9742.
Szewczuk, L.M.; Tarrant, M.K.; Cole, P.A. Protein phosphorylation by semisynthesis: from paper to practice. Methods Enzymol. 2009;462:1-24.
Tarrant, M.K.; Cole, P.A. The chemical biology of protein phosphorylation. Annual review of biochemistry. 2009;78:797-825.
Wang, D.; Xia, X.; Liu, Y.; Oetting, A.; Walker, R.L.; Zhu, Y.; Meltzer, P.; Cole, P.A.; Shi, Y.B.; Yen, P.M. Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation. Molecular endocrinology (Baltimore, Md. 2009 May;23(5):600-609.
Wang, M.H.; Shugart, Y.Y.; Cole, S.R.; Platz, E.A. A simulation study of control sampling methods for nested case-control studies of genetic and molecular biomarkers and prostate cancer progression. Cancer Epidemiol Biomarkers Prev. 2009;18(3):706-711.
Weitzman, S.; Braier, J.; Donadieu, J.; Egeler, R.M.; Grois, N.; Ladisch, S.; Potschger, U.; Webb, D.; Whitlock, J.; Arceci, R.J. 2'-Chlorodeoxyadenosine (2-CdA) as salvage therapy for Langerhans cell histiocytosis (LCH). results of the LCH-S-98 protocol of the Histiocyte Society. Pediatr Blood Cancer. 2009 Dec 15;53(7):1271-1276.
Wijdicks, C.A.; Armitage, B.M.; Anavian, J.; Schroder, L.K.; Cole, P.A. Vulnerable neurovasculature with a posterior approach to the scapula. Clin Orthop Relat Res. 2009 Aug;467(8):2011-2017.
Wikenheiser, J.; Wolfram, J.A.; Gargesha, M.; Yang, K.; Karunamuni, G.; Wilson, D.L.; Semenza, G.L.; Agani, F.; Fisher, S.A.; Ward, N.; Watanabe, M. Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomalies. Dev Dyn. 2009 Oct;238(10):2688-2700.
Yang, L.; Gaikwad, N.W.; Meza, J.; Cavalieri, E.L.; Muti, P.; Trock, B.; Rogan, E.G. Novel biomarkers for risk of prostate cancer: results from a case-control study. Prostate. 2009 Jan 1;69(1):41-48.
Bennett-Guerrero, E.; Pappas, T.N.; Koltun, W.A.; Fleshman, J.W.; Lin, M.; Garg, J.; Mark, D.B.; Marcet, J.E.; Remzi, F.H.; George, V.V.; Newland, K.; Corey, G.R. Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery. N Engl J Med. 2010 Sep 9;363(11):1038-1049.
Bowers, E.M.; Yan, G.; Mukherjee, C.; Orry, A.; Wang, L.; Holbert, M.A.; Crump, N.T.; Hazzalin, C.A.; Liszczak, G.; Yuan, H.; Larocca, C.; Saldanha, S.A.; Abagyan, R.; Sun, Y.; Meyers, D.J.; Marmorstein, R.; Mahadevan, L.C.; Alani, R.M.; Cole, P.A. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol. 2010 May 28;17(5):471-482.
Campbell, C.A.; Della Santina, C.C.; Meyer, N.C.; Smith, N.B.; Myrie, O.A.; Stone, E.M.; Fukushima, K.; Califano, J.; Carey, J.P.; Hansen, M.R.; Gantz, B.J.; Minor, L.B.; Smith, R.J. Polymorphisms in KCNE1 or KCNE3 are not associated with Meniere disease in the Caucasian population. Am J Med Genet A. 2010 Jan;152A(1):67-74.
Cerchietti, L.C.; Hatzi, K.; Caldas-Lopes, E.; Yang, S.N.; Figueroa, M.E.; Morin, R.D.; Hirst, M.; Mendez, L.; Shaknovich, R.; Cole, P.A.; Bhalla, K.; Gascoyne, R.D.; Marra, M.; Chiosis, G.; Melnick, A. BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy. J Clin Invest. 2010 Nov 1.
Chen, H.; Pimienta, G.; Gu, Y.; Sun, X.; Hu, J.; Kim, M.S.; Chaerkady, R.; Gucek, M.; Cole, R.N.; Sukumar, S.; Pandey, A. Proteomic characterization of Her2/neu-overexpressing breast cancer cells. Proteomics. 2010 Nov;10(21):3800-3810.
Culhane, J.C.; Wang, D.; Yen, P.M.; Cole, P.A. Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. J Am Chem Soc. 2010 Mar 10;132(9):3164-3176.
Fonseca, R.; Richardson, P.; Giralt, S.; Lonial, S.; Rajkumar, S.V.; Stewart, A.K.; Bensinger, W.; Somlo, G.; Vescio, R.; Mikhael, J.; Reeder, C.; Tiedemann, R.; Tricot, G.; Rifkin, R.; Shaughnessy, J.; Munshi, N.; Raje, N.; Ghobrial, I.; Laubach, J.; Schlossman, R.; Treon, S.; Mahindra, A.; Avigan, D.; Rosenblatt, J.; Jagannath, S.; Niesvizky, R.; Landau, H.; Chen-Kiang, S.; Siegel, D.S.; Zimmerman, T.; Mehta, J.; Vesole, D.; Rosen, S.; Hofmeister, C.; Lacy, M.; Dispenzieri, A.; Borrello, I.; Hayman, S.R.; Kumar, S.; Buadi, F.; Dingli, D.; Russell, S.; Melissa Alsina, M.A.; Fernandez, H.; Roy, V.; Pereira, D.; Stadtmauer, E.; Vij, R.; Jakubowiak, A.; Lentzsch, S.; Song, K.; Trudel, S.; Chen, C.; Reece, D.; Stewart, D.; Singhal, S.; Comenzo, R.; Gertz, M.A.; Greipp, P.R.; Durie, B.; Barlogie, B.; Anderson, K.; Dalton, W.; Coleman, M.; Novis, S.; Kyle, R.A. Conflicts of interest, authorship, and disclosures in industry-related scientific publications. Mayo Clin Proc. 2010 Feb;85(2):197-199; author reply 201-194.
Hayanga, A.J.; Mukherjee, D.; Chang, D.; Kaiser, H.; Lee, T.; Gearhart, S.; Ahuja, N.; Freischlag, J. Teaching hospital status and operative mortality in the United States: tipping point in the volume-outcome relationship following colon resections? Arch Surg. 2010 Apr;145(4):346-350
Huang, R.; Holbert, M.A.; Tarrant, M.K.; Curtet, S.; Colquhoun, D.R.; Dancy, B.M.; Dancy, B.C.; Hwang, Y.; Tang, Y.; Meeth, K.; Marmorstein, R.; Cole, R.N.; Khochbin, S.; Cole, P.A. Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation. J Am Chem Soc. 2010 Jul 28;132(29):9986-9987.
Hudson, T.J.; Anderson, W.; Artez, A.; Barker, A.D.; Bell, C.; Bernabe, R.R.; Bhan, M.K.; Calvo, F.; Eerola, I.; Gerhard, D.S.; Guttmacher, A.; Guyer, M.; Hemsley, F.M.; Jennings, J.L.; Kerr, D.; Klatt, P.; Kolar, P.; Kusada, J.; Lane, D.P.; Laplace, F.; Youyong, L.; Nettekoven, G.; Ozenberger, B.; Peterson, J.; Rao, T.S.; Remacle, J.; Schafer, A.J.; Shibata, T.; Stratton, M.R.; Vockley, J.G.; Watanabe, K.; Yang, H.; Yuen, M.M.; Knoppers, B.M.; Bobrow, M.; Cambon-Thomsen, A.; Dressler, L.G.; Dyke, S.O.; Joly, Y.; Kato, K.; Kennedy, K.L.; Nicolas, P.; Parker, M.J.; Rial-Sebbag, E.; Romeo-Casabona, C.M.; Shaw, K.M.; Wallace, S.; Wiesner, G.L.; Zeps, N.; Lichter, P.; Biankin, A.V.; Chabannon, C.; Chin, L.; Clement, B.; de Alava, E.; Degos, F.; Ferguson, M.L.; Geary, P.; Hayes, D.N.; Johns, A.L.; Kasprzyk, A.; Nakagawa, H.; Penny, R.; Piris, M.A.; Sarin, R.; Scarpa, A.; van de Vijver, M.; Futreal, P.A.; Aburatani, H.; Bayes, M.; Botwell, D.D.; Campbell, P.J.; Estivill, X.; Grimmond, S.M.; Gut, I.; Hirst, M.; Lopez-Otin, C.; Majumder, P.; Marra, M.; McPherson, J.D.; Ning, Z.; Puente, X.S.; Ruan, Y.; Stunnenberg, H.G.; Swerdlow, H.; Velculescu, V.E.; Wilson, R.K.; Xue, H.H.; Yang, L.; Spellman, P.T.; Bader, G.D.; Boutros, P.C.; Flicek, P.; Getz, G.; Guigo, R.; Guo, G.; Haussler, D.; Heath, S.; Hubbard, T.J.; Jiang, T.; Jones, S.M.; Li, Q.; Lopez-Bigas, N.; Luo, R.; Muthuswamy, L.; Ouellette, B.F.; Pearson, J.V.; Quesada, V.; Raphael, B.J.; Sander, C.; Speed, T.P.; Stein, L.D.; Stuart, J.M.; Teague, J.W.; Totoki, Y.; Tsunoda, T.; Valencia, A.; Wheeler, D.A.; Wu, H.; Zhao, S.; Zhou, G.; Lathrop, M.; Thomas, G.; Yoshida, T.; Axton, M.; Gunter, C.; Miller, L.J.; Zhang, J.; Haider, S.A.; Wang, J.; Yung, C.K.; Cross, A.; Liang, Y.; Gnaneshan, S.; Guberman, J.; Hsu, J.; Chalmers, D.R.; Hasel, K.W.; Kaan, T.S.; Lowrance, W.W.; Masui, T.; Rodriguez, L.L.; Vergely, C.; Bowtell, D.D.; Cloonan, N.; deFazio, A.; Eshleman, J.R.; Etemadmoghadam, D.; Gardiner, B.A.; Kench, J.G.; Sutherland, R.L.; Tempero, M.A.; Waddell, N.J.; Wilson, P.J.; Gallinger, S.; Tsao, M.S.; Shaw, P.A.; Petersen, G.M.; Mukhopadhyay, D.; DePinho, R.A.; Thayer, S.; Shazand, K.; Beck, T.; Sam, M.; Timms, L.; Ballin, V.; Lu, Y.; Ji, J.; Zhang, X.; Chen, F.; Hu, X.; Yang, Q.; Tian, G.; Zhang, L.; Xing, X.; Li, X.; Zhu, Z.; Yu, Y.; Yu, J.; Tost, J.; Brennan, P.; Holcatova, I.; Zaridze, D.; Brazma, A.; Egevard, L.; Prokhortchouk, E.; Banks, R.E.; Uhlen, M.; Viksna, J.; Ponten, F.; Skryabin, K.; Birney, E.; Borg, A.; Borresen-Dale, A.L.; Caldas, C.; Foekens, J.A.; Martin, S.; Reis-Filho, J.S.; Richardson, A.L.; Sotiriou, C.; Thoms, G.; van't Veer, L.; Birnbaum, D.; Blanche, H.; Boucher, P.; Boyault, S.; Masson-Jacquemier, J.D.; Pauporte, I.; Pivot, X.; Vincent-Salomon, A.; Tabone, E.; Theillet, C.; Treilleux, I.; Bioulac-Sage, P.; Decaens, T.; Franco, D.; Gut, M.; Samuel, D.; Zucman-Rossi, J.; Eils, R.; Brors, B.; Korbel, J.O.; Korshunov, A.; Landgraf, P.; Lehrach, H.; Pfister, S.; Radlwimmer, B.; Reifenberger, G.; Taylor, M.D.; von Kalle, C.; Majumder, P.P.; Pederzoli, P.; Lawlor, R.A.; Delledonne, M.; Bardelli, A.; Gress, T.; Klimstra, D.; Zamboni, G.; Nakamura, Y.; Miyano, S.; Fujimoto, A.; Campo, E.; de Sanjose, S.; Montserrat, E.; Gonzalez-Diaz, M.; Jares, P.; Himmelbaue, H.; Bea, S.; Aparicio, S.; Easton, D.F.; Collins, F.S.; Compton, C.C.; Lander, E.S.; Burke, W.; Green, A.R.; Hamilton, S.R.; Kallioniemi, O.P.; Ley, T.J.; Liu, E.T.; Wainwright, B.J. International network of cancer genome projects. Nature. 2010 Apr 15;464(7291):993-998.
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