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Dr. Jin Jen


Associate Professor of Otolaryngology - Head and Neck Surgery and Oncology


M.D., Medicine, Beijing Medical University, Beijing, China Ph.D., Biophysics, University of California San Francisco, San Francisco, CA


Fellow, Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 

Journal Citations

Powell SM, Petersen GM, Krush AJ, Booker S, Jen J, Giardiello FM, Hamilton SR, Vogelstein B, Kinzler KW: Molecular diagnosis of familial adenomatouis polyposis. N Engl J Med 1993;329:1982-87.

Parsons R, Li G-M, Longley MJ, Fang W-H, Papadopoulos N, Jen J, de la Chapelle A, Kinzler KW, Vogelstein B, Modrich P: Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 1993;75:1227-36.

Kim H, Jen J, Vogelstein B, Hamilton SR: Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 1994;145:148-56.

Jen J, Powell SM, Papadopoulos N, Smith KJ, Hamilton SR, Vogelstein B, Kinzler KW: Molecular determinants of dysplasia in colorectal lesions. Cancer Res 1994;54:5523-26.

Jen J, Kim H, Piantadosi S, Liu Z-F, Levitt RC, Sistonen P, Kinzler KW, Vogelstein B, Hamilton SR: Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med 1994;331:213-21.

Jen J, Harper JW, Bigner SH, Bigner DD, Papadopoulos N, Markowitz S, Willson JKV, Kinzler KW, Vogelstein B: Deletion of p16 and p15 genes in brain tumors. Cancer Res 1994;54:6353-58.

Liu B, Nicolaides NC, Markowitz S, Willson JKV, Parsons RE, Jen J, Papadopolous N, Peltomaki P, de la Chapelle A, Hamilton SR, Kinzler KW, Vogelstein B: Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genet 1995;9:48-55.

Herman JG, Jen J, Merlo A, Baylin SB: Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4b1. Cancer Res 1996;56:722-27.

Da Costa L, Jen J, He TC, Kinzler KW, Vogelstein B: Converting cancer genes into killer genes. Proc Natl Acad Sci U S A 1996;93:4192-96.

Jen J, Mitchell DL, Cunningham RP, Smith CA, Taylor JS, Cleaver JE: Ultraviolet irradiation produces novel endonuclease III-sensitive cytosine photoproducts at dipyrimidine sites. Photochem Photobiol 1997;65:323-29.

Okami K, Cairin P, Westra W, Linn J, Ahrent SA, Wu L, Sidransky D, Jen J: Detailed deletion mapping at chromosome 9p21 in non-small cell lung cancer by microsatellite analysis and fluorescence in situ hybridization. Int J Cancer 1997;74:1-5.

Ahrendt SA, Yang SC, Wu L, Westra WH, Jen J, Califano JA, Sidransky D: Comparison of oncogene mutation detection and telomerase activity for the molecular staging of non-small cell lung cancer. Clin Cancer Res 1997;3:1207-14.

Cairns P, Okami K, King P, Bonacum J, Ahrendt S, Wu L, Mao L, Jen J, Sidransky D: Genomic organization and mutation analysis of HEL-N1 in lung cancers with CH. 9p21 deletions. Cancer Res 1997;57:5356.

Okami K, Wu Li, Riggins G, Cairns P, Goggins M, Evron E, Halachmi N, Ahrendt S, Reed A, Hilgers W, Kern S, Sidransky D, Jen J: Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. Cancer Res 1998;58:509-11.

Jen J, Johnson C, Levin B: Molecular approaches for colorectal cancer screening (Review). Eur J Gastroenterol Hepatol 1998;10:213-17.

Hibi K, Robinson R, Booker S, Wu L, Hamilton S, Sidransky D, Jen J: Molecular detection of genetic alterations in the serum of colorectal cancer patients. Cancer Res 1998;58:509-11.

Trick B, Okami K, Wu L, Sriuranpong V, Jen J, Sidransky D: A new human p53 homologue. Nat Med 1998;4:3-4.

Leong PP, Rezai B, Koch WM, Reed A, Eisele D, Lee DJ, Sidransky D, Jen J, Westra WH: Distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma. J Natl Cancer Inst 1998;90:972-77.

Pai SI, Wu GS, Ozoren N, Wu L, Jen J, Sidransky D, El-Deiry WS: Rare loss-of-function mutation of a death receptor gene in head and neck cancer. Cancer Res 1998;58:3513-18.

Hibi K, Liu Q, Westra W, Wehage S, Borges M, Yang S, Heitmiller R, Sidransky D, Jen J: Serial analysis of genes overexpressed in non-small cell lung cancer. Cancer Res 1998;58:5690-94.

Sanchez-Cespedes M, Cairns P, Jen J, Sidransky D: Degerate oligonucleotide-primed PCR (DOP-PCR): evaluation of its reliability for screening of genetic alterations in neoplasia. Biotechniques 1998;25:1036-39.

Ahrendt SA, Chow JT, Xu LH, Yang CS, Eisenberger CF, Esteller M, Herman JG, Wu L, Jen J, Sidransky D: Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early-stage lung cancer. J Natl Cancer Inst 1999;91:332-39.

Hibi K, Westra WH, Borges M, Goodman S, Sidransky D, Jen J: PGP9.5 as a candidate tumor marker for non-small-cell lung cancer. Am J Pathol 1999;155:711-15.

Makiko SF, Usadel H, Caballero OL, Wu L, Buta M, Westra W, Eleff S, Jen J, Sidransky D: Facile detection of humoplasmic mitochondrial DNA mutations in primary tumors and bodily fluids. Science 2000;287:2017.

Yamaguchi K, Wu L, Hibi K, Trink B, Cairns P, Okami K, Sidransky D, Jen J: Frequent gain of the p40/p51/p63 gene locus in primary HNSCC. Int J Cancer (In press).

Xu L-H, Chow J, Eisenberger C, Bonacum J, Ahrendt S, Reed A, Spafford M, Westra WH, Yang S, Sheng ML, Piantadosi S, Tockman M, Sidransky D, Jen J: Microsatellite instability at (AAAG) repeat sequences in upper aerodigestive tract cancers (In press).

Hibi K, Trink B, Ratovitski EA, Westra WH, Resto V, Rocco J, Wu L, Jen J, Sidransky D: AIS is a putative oncogene frequently amplified in squamouse cell cancers. Proc Natl Acad Sci U S A (In press).


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