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Dr. Joseph Califano

Professor, Head and Neck Division, Division of Head and Neck Cancer Research
410-955-6420 (p)
Schools\Degrees

1985, B.A., Chemistry, Amherst College, Amherst, Massachusetts, 1993, M.D., Harvard Medical School, Boston, Massachusetts 1993- 1994, Intern, General Surgery, Johns Hopkins Hospital, Baltimore, Maryland 1994-1999, Resident, Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland 1994-1996, Research Training in Otolaryngology NIH grant T32, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland 1999-2000, Fellow-Head and Neck Division, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY

Certifications

Otolaryngology Fellow, American College of Surgeons

Journal Citations

Ha, P.K.; Califano, J.A. Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma. Lancet Oncol. 2006 Jan;7(1):77-82.
Ha, P.K.; Hdeib, A.; Goldenberg, D.; Jacene, H.; Patel, P.; Koch, W.; Califano, J.; Cummings, C.W.; Flint, P.W.; Wahl, R.; Tufano, R.P. The role of positron emission tomography and computed tomography fusion in the management of early-stage and advanced-stage primary head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2006 Jan;132(1):12-16.
Hu, S.; Liu, D.; Tufano, R.P.; Carson, K.A.; Rosenbaum, E.; Cohen, Y.; Holt, E.H.; Kiseljak-Vassiliades, K.; Rhoden, K.J.; Tolaney, S.; Condouris, S.; Tallini, G.; Westra, W.H.; Umbricht, C.B.; Zeiger, M.A.; Califano, J.A.; Vasko, V.; Xing, M. Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer. Int J Cancer. 2006 Nov 15;119(10):2322-2329.
Jiang, W.W.; Rosenbaum, E.; Mambo, E.; Zahurak, M.; Masayesva, B.; Carvalho, A.L.; Zhou, S.; Westra, W.H.; Alberg, A.J.; Sidransky, D.; Koch, W.; Califano, J.A. Decreased mitochondrial DNA content in posttreatment salivary rinses from head and neck cancer patients. Clin Cancer Res. 2006 Mar 1;12(5):1564-1569.
Jiang, W.W.; Zahurak, M.; Goldenberg, D.; Milman, Y.; Park, H.L.; Westra, W.H.; Koch, W.; Sidransky, D.; Califano, J. Increased plasma DNA integrity index in head and neck cancer patients. Int J Cancer. 2006 Dec 1;119(11):2673-2676.
Kim, M.M.; Glazer, C.A.; Mambo, E.; Chatterjee, A.; Zhao, M.; Sidransky, D.; Califano, J.A. Head and neck cancer cell lines exhibit differential mitochondrial repair deficiency in response to 4NQO. Oral Oncol. 2006 Feb;42(2):201-207.
Masayesva, B.G.; Mambo, E.; Taylor, R.J.; Goloubeva, O.G.; Zhou, S.; Cohen, Y.; Minhas, K.; Koch, W.; Sciubba, J.; Alberg, A.J.; Sidransky, D.; Califano, J. Mitochondrial DNA content increase in response to cigarette smoking. Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):19-24.
Serafini, P.; Meckel, K.; Kelso, M.; Noonan, K.; Califano, J.; Koch, W.; Dolcetti, L.; Bronte, V.; Borrello, I. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J Exp Med. 2006 Nov 27;203(12):2691-2702.
Sui, G.; Zhou, S.; Wang, J.; Canto, M.; Lee, E.E.; Eshleman, J.R.; Montgomery, E.A.; Sidransky, D.; Califano, J.A.; Maitra, A. Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: a biomarker for the early detection of cancer. Mol Cancer. 2006;5:73.
Wu, G.; Guo, Z.; Chatterjee, A.; Huang, X.; Rubin, E.; Wu, F.; Mambo, E.; Chang, X.; Osada, M.; Sook Kim, M.; Moon, C.; Califano, J.A.; Ratovitski, E.A.; Gollin, S.M.; Sukumar, S.; Sidransky, D.; Trink, B. Overexpression of glycosylphosphatidylinositol (GPI) transamidase subunits phosphatidylinositol glycan class T and/or GPI anchor attachment 1 induces tumorigenesis and contributes to invasion in human breast cancer. Cancer Res. 2006 Oct 15;66(20):9829-9836.
Zhou, S.; Kassauei, K.; Cutler, D.J.; Kennedy, G.C.; Sidransky, D.; Maitra, A.; Califano, J. An oligonucleotide microarray for high-throughput sequencing of the mitochondrial genome. J Mol Diagn. 2006 Sep;8(4):476-482.
Farrag, T.Y.; Koch, W.M.; Cummings, C.W.; Goldenberg, D.; Abou-Jaoude, P.M.; Califano, J.A.; Flint, P.W.; Webster, K.; Tufano, R.P. Supracricoid laryngectomy outcomes: The Johns Hopkins experience. Laryngoscope. 2007 Jan;117(1):129-132.
Farrag, T.Y.; Lin, F.R.; Koch, W.M.; Califano, J.A.; Cummings, C.W.; Farinola, M.A.; Tufano, R.P. The role of pre-operative CT-guided FNAB for parapharyngeal space tumors. Otolaryngol Head Neck Surg. 2007 Mar;136(3):411-414.
Jiang, W.W.; Zahurak, M.; Zhou, Z.T.; Park, H.L.; Guo, Z.M.; Wu, G.J.; Sidransky, D.; Trink, B.; Califano, J.A. Alterations of GPI transamidase subunits in head and neck squamous carcinoma. Mol Cancer. 2007 Nov 21;6(1):74.
Kim, M.S.; Yamashita, K.; Chae, Y.K.; Tokumaru, Y.; Chang, X.; Zahurak, M.; Osada, M.; Park, H.L.; Chuang, A.; Califano, J.A.; Sidransky, D. A promoter methylation pattern in the N-methyl-D-aspartate receptor 2B gene predicts poor prognosis in esophageal squamous cell carcinoma. Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6658-6665.
Liu, C.; Zhou, S.; Begum, S.; Sidransky, D.; Westra, W.H.; Brock, M.; Califano, J.A. Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer. Lung Cancer. 2007 Mar;55(3):303-311.
Mithani, S.K.; Mydlarz, W.K.; Grumbine, F.L.; Smith, I.M.; Califano, J.A. Molecular genetics of premalignant oral lesions. Oral Dis. 2007 Mar;13(2):126-133.
Mithani, S.K.; Smith, I.M.; Zhou, S.; Gray, A.; Koch, W.M.; Maitra, A.; Califano, J.A. Mitochondrial resequencing arrays detect tumor-specific mutations in salivary rinses of patients with head and neck cancer. Clin Cancer Res. 2007 Dec 15;13(24):7335-7340.
Mithani, S.K.; Taube, J.M.; Zhou, S.; Smith, I.M.; Koch, W.M.; Westra, W.H.; Califano, J.A. Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4331-4335.
Nayak, C.S.; Carvalho, A.L.; Jeronimo, C.; Henrique, R.; Kim, M.M.; Hoque, M.O.; Chang, S.; Jiang, W.W.; Koch, W.; Westra, W.; Sidransky, D.; Califano, J. Positive correlation of tissue inhibitor of metalloproteinase-3 and death-associated protein kinase hypermethylation in head and neck squamous cell carcinoma. Laryngoscope. 2007 Aug;117(8):1376-1380.
Poeta, M.L.; Manola, J.; Goldwasser, M.A.; Forastiere, A.; Benoit, N.; Califano, J.A.; Ridge, J.A.; Goodwin, J.; Kenady, D.; Saunders, J.; Westra, W.; Sidransky, D.; Koch, W.M. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med. 2007 Dec 20;357(25):2552-2561.
Seng, T.J.; Low, J.S.; Li, H.; Cui, Y.; Goh, H.K.; Wong, M.L.; Srivastava, G.; Sidransky, D.; Califano, J.; Steenbergen, R.D.; Rha, S.Y.; Tan, J.; Hsieh, W.S.; Ambinder, R.F.; Lin, X.; Chan, A.T.; Tao, Q. The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation. Oncogene. 2007 Feb 8;26(6):934-944.
Smith, I.M.; Mydlarz, W.K.; Mithani, S.K.; Califano, J.A. DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage. Int J Cancer. 2007 Oct 15;121(8):1724-1728.
Zhou, S.; Kachhap, S.; Sun, W.; Wu, G.; Chuang, A.; Poeta, L.; Grumbine, L.; Mithani, S.K.; Chatterjee, A.; Koch, W.; Westra, W.H.; Maitra, A.; Glazer, C.; Carducci, M.; Sidransky, D.; McFate, T.; Verma, A.; Califano, J.A. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7540-7545.
Carvalho, A.L.; Jeronimo, C.; Kim, M.M.; Henrique, R.; Zhang, Z.; Hoque, M.O.; Chang, S.; Brait, M.; Nayak, C.S.; Jiang, W.W.; Claybourne, Q.; Tokumaru, Y.; Lee, J.; Goldenberg, D.; Garrett-Mayer, E.; Goodman, S.; Moon, C.S.; Koch, W.; Westra, W.H.; Sidransky, D.; Califano, J.A. Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma. Clin Cancer Res. 2008 Jan 1;14(1):97-107.
Chang, S.S.; Califano, J. Current status of biomarkers in head and neck cancer. J Surg Oncol. 2008 Jun 15;97(8):640-643.
Chang, S.S.; Jiang, W.W.; Smith, I.; Poeta, L.M.; Begum, S.; Glazer, C.; Shan, S.; Westra, W.; Sidransky, D.; Califano, J.A. MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer. 2008 Dec 15;123(12):2791-2797.
Chatterjee, A.; Chang, X.; Nagpal, J.K.; Chang, S.; Upadhyay, S.; Califano, J.; Trink, B.; Sidransky, D. Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from 2-methoxyestradiol-induced-mitochondria-dependent apoptosis. Oncogene. 2008 Jun 12;27(26):3710-3720.
Chuang, A.Y.; Chuang, T.C.; Chang, S.; Zhou, S.; Begum, S.; Westra, W.H.; Ha, P.K.; Koch, W.M.; Califano, J.A. Presence of HPV DNA in convalescent salivary rinses is an adverse prognostic marker in head and neck squamous cell carcinoma. Oral Oncol. 2008 Oct;44(10):915-919.
Glazer, C.A.; Chang, S.S.; Ha, P.K.; Califano, J.A. Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice. Oral Oncol. 2008 Jul 30.
Goldenberg, D.; Begum, S.; Westra, W.H.; Khan, Z.; Sciubba, J.; Pai, S.I.; Califano, J.A.; Tufano, R.P.; Koch, W.M. Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon. Head Neck. 2008 Jul;30(7):898-903.
Gu, X.; Song, X.; Dong, Y.; Cai, H.; Walters, E.; Zhang, R.; Pang, X.; Xie, T.; Guo, Y.; Sridhar, R.; Califano, J.A. Vitamin E succinate induces ceramide-mediated apoptosis in head and neck squamous cell carcinoma in vitro and in vivo. Clin Cancer Res. 2008 Mar 15;14(6):1840-1848.
Hao, Y.; Xie, T.; Korotcov, A.; Zhou, Y.; Pang, X.; Shan, L.; Ji, H.; Sridhar, R.; Wang, P.; Califano, J.; Gu, X. Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivovia cyclooxygenase-2 and apoptotic pathways. Int J Cancer. 2008 Nov 19.
Hoque, M.O.; Kim, M.S.; Ostrow, K.L.; Liu, J.; Wisman, G.B.; Park, H.L.; Poeta, M.L.; Jeronimo, C.; Henrique, R.; Lendvai, A.; Schuuring, E.; Begum, S.; Rosenbaum, E.; Ongenaert, M.; Yamashita, K.; Califano, J.; Westra, W.; van der Zee, A.G.; Van Criekinge, W.; Sidransky, D. Genome-wide promoter analysis uncovers portions of the cancer methylome. Cancer Res. 2008 Apr 15;68(8):2661-2670.
Kim, M.S.; Lebron, C.; Nagpal, J.K.; Chae, Y.K.; Chang, X.; Huang, Y.; Chuang, T.; Yamashita, K.; Trink, B.; Ratovitski, E.A.; Califano, J.A.; Sidransky, D. Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer. Biochem Biophys Res Commun. 2008 May 23;370(1):38-43.
Liu, J.W.; Nagpal, J.K.; Sun, W.; Lee, J.; Kim, M.S.; Ostrow, K.L.; Zhou, S.; Jeronimo, C.; Henrique, R.; Van Criekinge, W.; Moon, C.S.; Califano, J.A.; Trink, B.; Sidransky, D. ssDNA-binding protein 2 is frequently hypermethylated and suppresses cell growth in human prostate cancer. Clin Cancer Res. 2008 Jun 15;14(12):3754-3760.
McFate, T.; Mohyeldin, A.; Lu, H.; Thakar, J.; Henriques, J.; Halim, N.D.; Wu, H.; Schell, M.J.; Tsang, T.M.; Teahan, O.; Zhou, S.; Califano, J.A.; Jeoung, N.H.; Harris, R.A.; Verma, A. Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. J Biol Chem. 2008 Aug 15;283(33):22700-22708.
Mithani, S.K.; Smith, I.M.; Topalian, S.L.; Califano, J.A. Nonsynonymous somatic mitochondrial mutations occur in the majority of cutaneous melanomas. Melanoma research. 2008 Jun;18(3):214-219.
Park, H.L.; Kim, M.S.; Yamashita, K.; Westra, W.; Carvalho, A.L.; Lee, J.; Jiang, W.W.; Baek, J.H.; Liu, J.; Osada, M.; Moon, C.S.; Califano, J.A.; Mori, M.; Sidransky, D. DCC promoter hypermethylation in esophageal squamous cell carcinoma. Int J Cancer. 2008 Jun 1;122(11):2498-2502.
Prasad, N.B.; Somervell, H.; Tufano, R.P.; Dackiw, A.P.; Marohn, M.R.; Califano, J.A.; Wang, Y.; Westra, W.H.; Clark, D.P.; Umbricht, C.B.; Libutti, S.K.; Zeiger, M.A. Identification of genes differentially expressed in benign versus malignant thyroid tumors. Clin Cancer Res. 2008 Jun 1;14(11):3327-3337.
Robbins, K.T.; Shaha, A.R.; Medina, J.E.; Califano, J.A.; Wolf, G.T.; Ferlito, A.; Som, P.M.; Day, T.A. Consensus statement on the classification and terminology of neck dissection. Arch Otolaryngol Head Neck Surg. 2008 May;134(5):536-538.
Shan, L.; Hao, Y.; Wang, S.; Korotcov, A.; Zhang, R.; Wang, T.; Califano, J.; Gu, X.; Sridhar, R.; Bhujwalla, Z.M.; Wang, P.C. Visualizing head and neck tumors in vivo using near-infrared fluorescent transferrin conjugate. Molecular imaging : official journal of the Society for Molecular Imaging. 2008 Jan-Feb;7(1):42-49.
van Zeeburg, H.J.; Snijders, P.J.; Wu, T.; Gluckman, E.; Soulier, J.; Surralles, J.; Castella, M.; van der Wal, J.E.; Wennerberg, J.; Califano, J.; Velleuer, E.; Dietrich, R.; Ebell, W.; Bloemena, E.; Joenje, H.; Leemans, C.R.; Brakenhoff, R.H. Clinical and molecular characteristics of squamous cell carcinomas from Fanconi anemia patients. J Natl Cancer Inst. 2008 Nov 19;100(22):1649-1653.
Woo, J.; Chae, Y.K.; Jang, S.J.; Kim, M.S.; Baek, J.H.; Park, J.C.; Trink, B.; Ratovitski, E.; Lee, T.; Park, B.; Park, M.; Kang, J.H.; Soria, J.C.; Lee, J.; Califano, J.; Sidransky, D.; Moon, C. Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium. Biochem Biophys Res Commun. 2008 Feb 8;366(2):321-327.
Woo, J.; Lee, J.; Chae, Y.K.; Kim, M.S.; Baek, J.H.; Park, J.C.; Park, M.J.; Smith, I.M.; Trink, B.; Ratovitski, E.; Lee, T.; Park, B.; Jang, S.J.; Soria, J.C.; Califano, J.A.; Sidransky, D.; Moon, C. Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation. Cancer Lett. 2008 Jun 8;264(1):54-62.
Zhao, M.; Begum, S.; Ha, P.K.; Westra, W.; Califano, J. Downregulation of RAD17 in head and neck cancer. Head Neck. 2008 Jan;30(1):35-42.
Zhao, M.; Mydlarz, W.K.; Zhou, S.; Califano, J. Head and neck cancer cell lines are resistant to mitochondrial-depolarization-induced apoptosis. ORL J Otorhinolaryngol Relat Spec. 2008 May 16;70(4):257-263.
Acha-Sagredo, A.; Ruesga, M.T.; Rodriguez, C.; Aguirregaviria, J.I.; Pancorbo, M.M.; Califano, J.A.; Aguirre, J.M. p53 mutation is rare in oral mucosa brushings from patients previously treated for a head and neck squamous cell carcinoma. Oral Oncol. 2009 Nov 20;45:661-664.
Ha, P.K.; Chang, S.S.; Glazer, C.A.; Califano, J.A.; Sidransky, D. Molecular techniques and genetic alterations in head and neck cancer. Oral Oncol. 2009 Jul 30;45:335-339.
Pattani, K.M.; Califano, J. Positive Sentinel Lymph Nodes are a Negative Prognostic Factor for Survival in T1-2 Oral/Oropharyngeal Cancer: A Long-Term Study on 103 Patients. Ann Surg Oncol. 2009 Nov 19;16:233-239.
Poeta, M.L.; Manola, J.; Goldenberg, D.; Forastiere, A.; Califano, J.A.; Ridge, J.A.; Goodwin, J.; Kenady, D.; Saunders, J.; Westra, W.; Sidransky, D.; Koch, W.M. The Ligamp TP53 Assay for Detection of Minimal Residual Disease in Head and Neck Squamous Cell Carcinoma Surgical Margins. Clin Cancer Res. 2009 Dec 15;15(24):7658-7665.
Sanguineti, G.; Califano, J.; Stafford, E.; Fox, J.; Koch, W.; Tufano, R.; Sormani, M.P.; Forastiere, A. Defining the Risk of Involvement for Each Neck Nodal Level in Patients With Early T-Stage Node-Positive Oropharyngeal Carcinoma. Int J Radiat Oncol Biol Phys. 2009 Jan 6.
Bai, W.; Shao, C.; Sun, W.; Ha, P.K.; Califano, J.A.; Cao, Z. Conservative management of transnasal intracranial injury. Am J Otolaryngol. 2010 Jan 6.
Bai, W.; Zhou, X.; Gao, X.; Shao, C.; Califano, J.A.; Ha, P.K. The value of chest CT in the diagnosis and management of tracheobronchial foreign bodies. Pediatr Int. 2010 Dec 3;Epub ahead of print.
Campbell, C.A.; Della Santina, C.C.; Meyer, N.C.; Smith, N.B.; Myrie, O.A.; Stone, E.M.; Fukushima, K.; Califano, J.; Carey, J.P.; Hansen, M.R.; Gantz, B.J.; Minor, L.B.; Smith, R.J. Polymorphisms in KCNE1 or KCNE3 are not associated with Meniere disease in the Caucasian population. Am J Med Genet A. 2010 Jan;152A(1):67-74.
Chang, S.S.; Jiang, W.W.; Smith, I.; Glazer, C.; Sun, W.Y.; Mithani, S.; Califano, J.A. Chronic cigarette smoke extract treatment selects for apoptotic dysfunction and mitochondrial mutations in minimally transformed oral keratinocytes. Int J Cancer. 2010 Jan 1;126(1):19-27.
Chang, S.S.; Smith, I.; Glazer, C.; Hennessey, P.; Califano, J.A. EIF2C is overexpressed and amplified in head and neck squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec. 2010;72(6):337-343.
Chang, X.; Monitto, C.L.; Demokan, S.; Kim, M.S.; Chang, S.S.; Zhong, X.; Califano, J.A.; Sidransky, D. Identification of hypermethylated genes associated with cisplatin resistance in human cancers. Cancer Res. 2010 Apr 1;70(7):2870-2879.
Dasgupta, S.; Koch, R.; Westra, W.H.; Califano, J.A.; Ha, P.K.; Sidransky, D.; Koch, W.M. Mitochondrial DNA mutation in normal margins and tumors of recurrent head and neck squamous cell carcinoma patients. Cancer Prev Res (Phila). 2010 Sep;3(9):1205-1211.
Demokan, S.; Chang, X.; Chuang, A.; Mydlarz, W.K.; Kaur, J.; Huang, P.; Khan, Z.; Khan, T.; Ostrow, K.L.; Brait, M.; Hoque, M.O.; Liegeois, N.J.; Sidransky, D.; Koch, W.; Califano, J.A. KIF1A and EDNRB are differentially methylated in primary HNSCC and salivary rinses. Int J Cancer. 2010 Nov 15;127(10):2351-2359.
Durr, M.L.; Mydlarz, W.K.; Shao, C.; Zahurak, M.L.; Chuang, A.Y.; Hoque, M.O.; Westra, W.H.; Liegeois, N.J.; Califano, J.A.; Sidransky, D.; Ha, P.K. Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors. PLoS One. 2010;5(5):e10828.
Huang, Y.; Chang, X.; Lee, J.; Cho, Y.G.; Zhong, X.; Park, I.S.; Liu, J.W.; Califano, J.A.; Ratovitski, E.A.; Sidransky, D.; Kim, M.S. Cigarette smoke induced promoter methylation of single-strand DNA-binding protein 2 in human esophageal squamous cell carcinoma. Int J Cancer. 2010 Jul 23.
Kaur, J.; Demokan, S.; Tripathi, S.C.; Macha, M.A.; Begum, S.; Califano, J.A.; Ralhan, R. Promoter hypermethylation in Indian primary oral squamous cell carcinoma. Int J Cancer. 2010 Nov 15;127(10):2367-2373.
Lee, J.; Jang, S.J.; Benoit, N.; Hoque, M.O.; Califano, J.A.; Trink, B.; Sidransky, D.; Mao, L.; Moon, C. Presence of 5-methylcytosine in CpNpG trinucleotides in the human genome. Genomics. 2010 Aug;96(2):67-72.
Loyo, M.; Brait, M.; Kim, M.S.; Ostrow, K.L.; Jie, C.C.; Chuang, A.Y.; Califano, J.A.; Liegeois, N.J.; Begum, S.; Westra, W.H.; Hoque, M.O.; Tao, Q.; Sidransky, D. A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma. Int J Cancer. 2010 May 6.
Loyo, M.; Guerrero-Preston, R.; Brait, M.; Hoque, M.O.; Chuang, A.; Kim, M.S.; Sharma, R.; Liegeois, N.J.; Koch, W.M.; Califano, J.A.; Westra, W.H.; Sidransky, D. Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission. Int J Cancer. 2010 Jun 15;126(12):2991-2996.
Mydlarz, W.K.; Hennessey, P.T.; Califano, J.A. Advances and Perspectives in the Molecular Diagnosis of Head and Neck Cancer. Expert Opin Med Diagn. 2010 Jan 1;4(1):53-65.
Pattani, K.M.; Zhang, Z.; Demokan, S.; Glazer, C.; Loyo, M.; Goodman, S.; Sidransky, D.; Bermudez, F.; Jean-Charles, G.; McCaffrey, T.; Padhya, T.; Phelan, J.; Spivakovsky, S.; Bowne, H.Y.; Goldberg, J.D.; Rolnitzky, L.; Robbins, M.; Kerr, A.R.; Sirois, D.; Califano, J.A. Endothelin receptor type B gene promoter hypermethylation in salivary rinses is independently associated with risk of oral cavity cancer and premalignancy. Cancer Prev Res (Phila). 2010 Sep;3(9):1093-1103.
Roh, J.L.; Kang, S.K.; Minn, I.; Califano, J.A.; Sidransky, D.; Koch, W.M. p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. Oral Oncol. 2010 Dec 15.
Rosin, M.P.; Califano, J.A. The epidermal growth factor receptor axis: support for a new target for oral premalignancy. Cancer Prev Res (Phila). 2010 Jul;3(7):797-799.
Shan, S.J.; Zahurak, M.; Khan, Z.; Califano, J.A. Reluctance to undergo follow-up screening for head and neck cancer is associated with income, gender, and tobacco use. ORL J Otorhinolaryngol Relat Spec. 2010;72(5):266-271.
Smith, I.M.; Mithani, S.K.; Mydlarz, W.K.; Chang, S.S.; Califano, J.A. Inactivation of the tumor suppressor genes causing the hereditary syndromes predisposing to head and neck cancer via promoter hypermethylation in sporadic head and neck cancers. ORL J Otorhinolaryngol Relat Spec. 2010;72(1):44-50.
Sun, W.; Liu, Y.; Glazer, C.A.; Shao, C.; Bhan, S.; Demokan, S.; Zhao, M.; Rudek, M.A.; Ha, P.K.; Califano, J.A. TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Clin Cancer Res. 2010 Feb 1;16(3):857-866.
Zhao, Y.; Hao, Y.; Ji, H.; Fang, Y.; Guo, Y.; Sha, W.; Zhou, Y.; Pang, X.; Southerland, W.M.; Califano, J.A.; Gu, X. Combination effects of salvianolic acid B with low-dose celecoxib on inhibition of head and neck squamous cell carcinoma growth in vitro and in vivo. Cancer Prev Res (Phila). 2010 Jun;3(6):787-796.

 

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