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Dr. David Huso

D.V.M., Ph.D.
Titles

Associate Professor of Comparative Medicine
Associate Professor of Oncology

Schools\Degrees

Ph.D., Johns Hopkins University D.V.M., Iowa State University

Training

Comparative Pathology Fellowship, Johns Hopkins University

Certifications

Diplomate American College of Veterinary Pathology

Clinical Interests

Stem cells, Development, and Murine Models in Translational Research

Research Summary

Dr. Huso’s research interests are centered on using mice as genetic systems to better understand stem cells, development and cancer and applying these insights to develop novel, targeted therapeutic strategies.

 

EM 5/06

Journal Citations

Agrawal, N., Bettegowda, C., Cheong, I., Geschwind, J. F., Drake, C. G., Hipkiss, E. L., et al. 2004. Bacteriolytic therapy can generate a potent immune response against experimental tumors. Proc. Natl. Acad. Sci. USA. 101:15172-15177.

Dang, L. H., Bettegowda, C., Agrawal, N., Cheong, I., Huso, D., Frost, P., et al. 2004. Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents. Cancer Biol. Ther. 3:326-337.

Dicello, J. F., Christian, A., Cucinotta, F. A., Gridley, D. S., Kathirithamby, R., Mann, J., et al. 2004. In vivo mammary tumourigenesis in the Sprague-Dawley rat and microdosimetric correlates. Phys. Med. Biol. 49:3817-3830.

Judge, D. P., Biery, N. J., Keene, D. R., Geubtner, J., Myers, L., Huso, D. L., et al. 2004. Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome. J. Clin. Invest. 114:172-181.

Peterson, N. C., Servinsky, M. D., Christian, A., Peng, Z., Qiu, W., Mann, J., et al. 2005. Tamoxifen resistance and Her2/neu expression in an aged, irradiated rat breast carcinoma model. Carcinogenesis. 26:1542-1552.

Piontek, K. B., Huso, D. L., Grinberg, A., Liu, L., Bedja, D., Zhao, H., et al. 2004. A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J. Am. Soc. Nephrol. 15:3035-3043.

Reid, W., Abdelwahab, S., Sadowska, M., Huso, D., Neal, A., Ahearn, A., et al. 2004. HIV transgenic rats develop T cell abnormalities. Virology. 321:111-119.

Sun, L. Q., Lee, D., Zhang, Q., Xiao, W., Raabe, E., Meeker, A., et al. 2004. Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene PASG. Gene. Dev. 18:1035-1046.

Xu, Y., Sumter, T. F., Bhattacharya, R., Tesfaye, A., Fuchs, E. J., Wood, L. J., et al. 2004. The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia. Cancer Res. 64:3371-3375.

Murata, S.; Kominsky, S.L.; Vali, M.; Zhang, Z.; Garrett-Mayer, E.; Korz, D.; Huso, D.; Baker, S.D.; Barber, J.; Jaffee, E.; Reilly, R.T.; Sukumar, S. Ductal access for prevention and therapy of mammary tumors. Cancer Res. 2006 Jan 15;66(2):638-645.

Nanda, A.; Karim, B.; Peng, Z.; Liu, G.; Qiu, W.; Gan, C.; Vogelstein, B.; St Croix, B.; Kinzler, K.W.; Huso, D.L. Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3351-3356.

Piloto, O.; Nguyen, B.; Huso, D.; Kim, K.T.; Li, Y.; Witte, L.; Hicklin, D.J.; Brown, P.; Small, D. IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples. Cancer Res. 2006 May 1;66(9):4843-4851.

Zhou, Y.F.; Bosch-Marce, M.; Okuyama, H.; Krishnamachary, B.; Kimura, H.; Zhang, L.; Huso, D.L.; Semenza, G.L. Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. Cancer Res. 2006 Nov 15;66(22):10849-10854.

Baldwin, B.R.; Li, L.; Tse, K.F.; Small, S.; Collector, M.; Whartenby, K.A.; Sharkis, S.J.; Racke, F.; Huso, D.; Small, D. Transgenic mice expressing Tel-FLT3, a constitutively activated form of FLT3, develop myeloproliferative disease. Leukemia. 2007 Apr;21(4):764-771.

Osburn, W.O.; Karim, B.; Dolan, P.M.; Liu, G.; Yamamoto, M.; Huso, D.L.; Kensler, T.W. Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. Int J Cancer. 2007 Nov 1;121(9):1883-1891.

Tesfaye, A.; Di Cello, F.; Hillion, J.; Ronnett, B.M.; Elbahloul, O.; Ashfaq, R.; Dhara, S.; Prochownik, E.; Tworkoski, K.; Reeves, R.; Roden, R.; Ellenson, L.H.; Huso, D.L.; Resar, L.M. The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis. Cancer Res. 2007 May 1;67(9):3998-4004.

Di Cello, F.; Hillion, J.; Kowalski, J.; Ronnett, B.M.; Aderinto, A.; Huso, D.L.; Resar, L.M. Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts. Mol Cancer Ther. 2008 Jul;7(7):2090-2095.

Huang, G.N.; Huso, D.L.; Bouyain, S.; Tu, J.; McCorkell, K.A.; May, M.J.; Zhu, Y.; Lutz, M.; Collins, S.; Dehoff, M.; Kang, S.; Whartenby, K.; Powell, J.; Leahy, D.; Worley, P.F. NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science. 2008 Jan 25;319(5862):476-481.

Li, L.; Piloto, O.; Nguyen, H.B.; Greenberg, K.; Takamiya, K.; Racke, F.; Huso, D.; Small, D. Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model. Blood. 2008 Apr 1;111(7):3849-3858.

Song, H.; Shahverdi, K.; Huso, D.L.; Esaias, C.; Fox, J.; Liedy, A.; Zhang, Z.; Reilly, R.T.; Apostolidis, C.; Morgenstern, A.; Sgouros, G. 213Bi (alpha-emitter)-antibody targeting of breast cancer metastases in the neu-N transgenic mouse model. Cancer Res. 2008 May 15;68(10):3873-3880.

Song, H.; Shahverdi, K.; Huso, D.L.; Wang, Y.; Fox, J.J.; Hobbs, R.F.; Gimi, B.; Gabrielson, K.L.; Pomper, M.G.; Tsui, B.M.; Bhujwalla, Z.; Reilly, R.T.; Sgouros, G. An immunotolerant HER-2/neu transgenic mouse model of metastatic breast cancer. Clin Cancer Res. 2008 Oct 1;14(19):6116-6124.

Rhee, K.J.; Wu, S.; Wu, X.; Huso, D.L.; Karim, B.; Franco, A.A.; Rabizadeh, S.; Golub, J.E.; Mathews, L.E.; Shin, J.; Sartor, R.B.; Golenbock, D.; Hamad, A.R.; Gan, C.M.; Housseau, F.; Sears, C.L. Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice. Infect Immun. 2009 Apr;77(4):1708-1718.

Song, H.; Hobbs, R.F.; Vajravelu, R.; Huso, D.L.; Esaias, C.; Apostolidis, C.; Morgenstern, A.; Sgouros, G. Radioimmunotherapy of breast cancer metastases with alpha-particle emitter 225Ac: comparing efficacy with 213Bi and 90Y. Cancer Res. 2009 Dec 1;69(23):8941-8948.

Wu, S.; Rhee, K.J.; Albesiano, E.; Rabizadeh, S.; Wu, X.; Yen, H.R.; Huso, D.L.; Brancati, F.L.; Wick, E.; McAllister, F.; Housseau, F.; Pardoll, D.M.; Sears, C.L. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med. 2009 Sep;15(9):1016-1022.

Ericson, K.; Gan, C.; Cheong, I.; Rago, C.; Samuels, Y.; Velculescu, V.E.; Kinzler, K.W.; Huso, D.L.; Vogelstein, B.; Papadopoulos, N. Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2598-2603.

Garcia-Gonzalez, M.A.; Outeda, P.; Zhou, Q.; Zhou, F.; Menezes, L.F.; Qian, F.; Huso, D.L.; Germino, G.G.; Piontek, K.B.; Watnick, T. Pkd1 and Pkd2 are required for normal placental development. PLoS One. 2010;5(9).

Lax, S.; Hardie, D.L.; Wilson, A.; Douglas, M.R.; Anderson, G.; Huso, D.; Isacke, C.M.; Buckley, C.D. The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion. Eur J Immunol. 2010 Jul;40(7):1884-1889.

Lien, C.; Fang, C.M.; Huso, D.; Livak, F.; Lu, R.; Pitha, P.M. Critical role of IRF-5 in regulation of B-cell differentiation. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4664-4668.

Matt, P.; Huso, D.L.; Habashi, J.; Holm, T.; Doyle, J.; Schoenhoff, F.; Liu, G.; Black, J.; Van Eyk, J.E.; Dietz, H.C. Murine model of surgically induced acute aortic dissection type A. J Thorac Cardiovasc Surg. 2010 Apr;139(4):1041-1047.

Orsburn, B.; Escudero, B.; Prakash, M.; Gesheva, S.; Liu, G.; Huso, D.L.; Franco, S. Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1. Mol Cell Biol. 2010 May;30(10):2341-2352.

Schmidt-Kittler, O.; Zhu, J.; Yang, J.; Liu, G.; Hendricks, W.; Lengauer, C.; Gabelli, S.B.; Kinzler, K.W.; Vogelstein, B.; Huso, D.L.; Zhou, S. PI3Kalpha Inhibitors That Inhibit Metastasis. Oncotarget. 2010 Sep 1;1(5):339-348.

Wang, Y.; Sun, M.; Uhlhorn, V.L.; Zhou, X.; Peter, I.; Martinez-Abadias, N.; Hill, C.A.; Percival, C.J.; Richtsmeier, J.T.; Huso, D.L.; Jabs, E.W. Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice. BMC Dev Biol. 2010;10:22.

Yamakuchi, M.; Lotterman, C.D.; Bao, C.; Hruban, R.H.; Karim, B.; Mendell, J.T.; Huso, D.; Lowenstein, C.J. P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6334-6339.


 

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