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Dr. Peter Barker

D. Phil.

Professor of Radiology


D.Phil. in Physical Chemistry, Oxford University, United Kingdom


Postdoctoral Research, California Institute of Technology

Research Summary

Dr. Barker’s funded research projects include the development of techniques for proton magnetic resonance spectroscopic imaging (MRSI) for the diagnosis of breast cancer, and the investigation of brain metabolism in Neurofibromatosis Type-1 (NF1). MRSI may play a role in understanding the causes of NF1-associated cognitive impairment, as well as in the diagnosis of brain lesions in patients with NF1. 


A major goal of Dr Barker’s research group is to provide state-of-the-art magnetic resonance imaging (MRI) and MRSI data acquisition and image processing technology, and unique MRI expertise, to facilitate the biomedical research of NIH-funded neuroscientists at institutions throughout Maryland and the United States.

Journal Citations

Edden, R.A.; Schar, M.; Hillis, A.E.; Barker, P.B. Optimized detection of lactate at high fields using inner volume saturation. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2006 Oct;56(4):912-917.

Franco, L.P.; Anderson, J.; Okoh, J.; Pomper, M.G.; Braverman, N.; Barker, P.B. Proton MR spectroscopy in hyperhomocysteinemia with elevated blood methionine levels. Journal of magnetic resonance imaging : JMRI. 2006 Mar;23(3):404-407.

Hourani, R.; Horska, A.; Albayram, S.; Brant, L.J.; Melhem, E.; Cohen, K.J.; Burger, P.C.; Weingart, J.D.; Carson, B.; Wharam, M.D.; Barker, P.B. Proton magnetic resonance spectroscopic imaging to differentiate between nonneoplastic lesions and brain tumors in children. Journal of magnetic resonance imaging : JMRI. 2006 Feb;23(2):99-107.

Lin, D.D.; Barker, P.B. Neuroimaging of phakomatoses. Seminars in Pediatric Neurology. 2006 Mar;13(1):48-62.

Lin, D.D.; Barker, P.B.; Hatfield, L.A.; Comi, A.M. Dynamic MR perfusion and proton MR spectroscopic imaging in Sturge-Weber syndrome: correlation with neurological symptoms. Journal of magnetic resonance imaging : JMRI. 2006 Aug;24(2):274-281.

Edden, R.A.; Pomper, M.G.; Barker, P.B. In vivo differentiation of N-acetyl aspartyl glutamate from N-acetyl aspartate at 3 Tesla. Magn Reson Med. 2007 Jun;57(6):977-982.

Turtzo, L.C.; Lin, D.D.; Hartung, H.; Barker, P.B.; Arceci, R.; Yohay, K. A neurologic presentation of familial hemophagocytic lymphohistiocytosis which mimicked septic emboli to the brain. Journal of child neurology. 2007 Jul;22(7):863-868.

Baker, E.H.; Basso, G.; Barker, P.B.; Smith, M.A.; Bonekamp, D.; Horska, A. Regional apparent metabolite concentrations in young adult brain measured by (1)H MR spectroscopy at 3 Tesla. Journal of magnetic resonance imaging : JMRI. 2008 Mar;27(3):489-499.

Bizzi, A.; Castelli, G.; Bugiani, M.; Barker, P.B.; Herskovits, E.H.; Danesi, U.; Erbetta, A.; Moroni, I.; Farina, L.; Uziel, G. Classification of childhood white matter disorders using proton MR spectroscopic imaging. AJNRAmerican journal of neuroradiology. 2008 Aug;29(7):1270-1275.

Brenner, C.; Speck-Martins, C.E.; Farage, L.; Barker, P.B. 3T MR with diffusion tensor imaging and single-voxel spectroscopy in giant axonal neuropathy. Journal of magnetic resonance imaging : JMRI. 2008 Jul;28(1):236-241.

Hourani, R.; Brant, L.J.; Rizk, T.; Weingart, J.D.; Barker, P.B.; Horska, A. Can proton MR spectroscopic and perfusion imaging differentiate between neoplastic and nonneoplastic brain lesions in adults? AJNRAmerican journal of neuroradiology. 2008 Feb;29(2):366-372.

Jakupciak, J.P.; Maragh, S.; Markowitz, M.E.; Greenberg, A.K.; Hoque, M.O.; Maitra, A.; Barker, P.E.; Wagner, P.D.; Rom, W.N.; Srivastava, S.; Sidransky, D.; O'Connell, C.D. Performance of mitochondrial DNA mutations detecting early stage cancer. BMC Cancer. 2008;8:285.

Smith, S.A.; Edden, R.A.; Farrell, J.A.; Barker, P.B.; van Zijl, P.C. Measurement of T1 and T2 in the cervical spinal cord at 3 tesla. Vol. 60, Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. United States: Wiley-Liss, Inc; 2008. p. 213-219.

Horska, A.; Farage, L.; Bibat, G.; Nagae, L.M.; Kaufmann, W.E.; Barker, P.B.; Naidu, S. Brain metabolism in rett syndrome: Age, clinical, and genotype correlations. Annals of Neurology. 2009 Feb 4;65(1):90-97.

Lin, D.D.; Kleinman, J.T.; Wityk, R.J.; Gottesman, R.F.; Hillis, A.E.; Lee, A.W.; Barker, P.B. Crossed Cerebellar Diaschisis in Acute Stroke Detected by Dynamic Susceptibility Contrast MR Perfusion Imaging. AJNRAmerican journal of neuroradiology. 2009 Feb 4;30:710-715.

Rowland, L.M.; Spieker, E.A.; Francis, A.; Barker, P.B.; Carpenter, W.T.; Buchanan, R.W. White Matter Alterations in Deficit Schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2009 Dec 3;34(6):1514-1522.

Horska, A.; Barker, P.B. Imaging of brain tumors: MR spectroscopy and metabolic imaging. Neuroimaging clinics of North America. 2010;20(3):293-310.

Jacobs, M.A.; Stearns, V.; Wolff, A.C.; Macura, K.; Argani, P.; Khouri, N.; Tsangaris, T.; Barker, P.B.; Davidson, N.E.; Bhujwalla, Z.M.; Bluemke, D.A.; Ouwerkerk, R. Multiparametric magnetic resonance imaging, spectroscopy and multinuclear ((2)(3)Na) imaging monitoring of preoperative chemotherapy for locally advanced breast cancer. Acad Radiol. 2010 Dec;17(12):1477-1485.

Lentz, M.R.; Degaonkar, M.; Mohamed, M.A.; Kim, H.; Conant, K.; Halpern, E.F.; Sacktor, N.; Barker, P.B.; Pomper, M.G. Exploring the relationship of macrophage colony-stimulating factor levels on neuroaxonal metabolism and cognition during chronic human immunodeficiency virus infection. J Neurovirol. 2010 Oct;16(5):368-376.

Mohamed, M.A.; Barker, P.B.; Skolasky, R.L.; Selnes, O.A.; Moxley, R.T.; Pomper, M.G.; Sacktor, N.C. Brain metabolism and cognitive impairment in HIV infection: a 3-T magnetic resonance spectroscopy study. Magn Reson Imaging. 2010 Nov;28(9):1251-1257.

Mohamed, M.A.; Lentz, M.R.; Lee, V.; Halpern, E.F.; Sacktor, N.; Selnes, O.; Barker, P.B.; Pomper, M.G. Factor analysis of proton MR spectroscopic imaging data in HIV infection: metabolite-derived factors help identify infection and dementia. Radiology. 2010 Feb;254(2):577-586.

Zhu, H.; Jones, C.K.; van Zijl, P.C.; Barker, P.B.; Zhou, J. Fast 3D chemical exchange saturation transfer (CEST) imaging of the human brain. Magn Reson Med. 2010 Sep;64(3):638-644.


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