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Cynthia Sears

410-955-1725 (p)

General Internal Medicine, Infectious Disease


Professor of Medicine


Journal Citations

Buckwold, S.L.; Shoemaker, N.B.; Sears, C.L.; Franco, A.A. Identification and characterization of conjugative transposons CTn86 and CTn9343 in Bacteroides fragilis strains. Applied and environmental microbiology. 2007 Jan;73(1):53-63.

Wu, S.; Rhee, K.J.; Zhang, M.; Franco, A.; Sears, C.L. Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage. J Cell Sci. 2007 Jun 1;120(Pt 11):1944-1952.

Kohli, A.; Bushen, O.Y.; Pinkerton, R.C.; Houpt, E.; Newman, R.D.; Sears, C.L.; Lima, A.A.; Guerrant, R.L. Giardia duodenalis assemblage, clinical presentation and markers of intestinal inflammation in Brazilian children. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2008 Jul;102(7):718-725.

Said, M.A.; Perl, T.M.; Sears, C.L. Healthcare epidemiology: gastrointestinal flu: norovirus in health care and long-term care facilities. Clin Infect Dis. 2008 Nov 1;47(9):1202-1208.

Rhee, K.J.; Wu, S.; Wu, X.; Huso, D.L.; Karim, B.; Franco, A.A.; Rabizadeh, S.; Golub, J.E.; Mathews, L.E.; Shin, J.; Sartor, R.B.; Golenbock, D.; Hamad, A.R.; Gan, C.M.; Housseau, F.; Sears, C.L. Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice. Infect Immun. 2009 Apr;77(4):1708-1718.

Sears, C.L. Enterotoxigenic Bacteroides fragilis: A Rogue among Symbiotes. Clinical Microbiology Reviews 2009;22(2):349-369.

Wu, S.; Rhee, K.J.; Albesiano, E.; Rabizadeh, S.; Wu, X.; Yen, H.R.; Huso, D.L.; Brancati, F.L.; Wick, E.; McAllister, F.; Housseau, F.; Pardoll, D.M.; Sears, C.L. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med. 2009 Sep;15(9):1016-1022.

Housseau, F.; Sears, C.L. Enterotoxigenic Bacteroides fragilis (ETBF)-mediated colitis in Min (Apc+/-) mice: a human commensal-based murine model of colon carcinogenesis. Cell Cycle. 2010 Jan 1;9(1):3-5.

Sears, C.L.; Cosgrove, S.E. IV or not IV? Just one of the antibiotic questions in Whipple's disease. Gastroenterology. 2010 Feb;138(2):422-426.

Wick, E.C.; Sears, C.L. Bacteroides spp. and diarrhea. Curr Opin Infect Dis. 2010 Oct;23(5):470-474.


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