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Dr. Steven Goodman

M.D., Ph.D.
Steven Goodman
Titles

Associate Professor of Oncology and Pediatrics
Joint Appointments in Epidemiology and Biostatistics,The Johns Hopkins Bloomberg School of Public Health

Schools\Degrees

M.D., New York University School of Medicine, New York, NY Ph.D., Johns Hopkins Univeristy School of Hygiene and Public Health, Baltimore, MD

Training

Resident in Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri

Research Summary

Dr. Goodman’s main role in the Kimmel Cancer Center has been to support the design, conduct, and analysis of clinical trials within the Center, as well as to assist those who work at the interface of molecular biology and clinical medicine to identify molecular markers of cancer risk or prognosis after cancer diagnosis. He supports the work of the GI Spore and has been particularly active in the design of Phase I studies within the center, promoting a new Bayesian methodology for Phase I trials that is more flexible, safer, and more likely to treat patients at optimal doses than traditional dose-finding methods.

 

Dr. Goodman’s other major interest is in the ethical dimensions of clinical research, and he is on the faculty of the new Johns Hopkins Bioethics Institute. He served as a consultant for the president’s Commission on Human Radiation Experiments, conducted a national survey of cancer patients’ attitudes towards clinical research, and is currently involved in a project examining patients’ attitudes, understanding, and the informed- consent process in Phase I cancer clinical trials.

In addition to his research activities, one of Dr. Goodman’s core missions at the Oncology Center, together with his other colleagues in the Division of Biostatistics, is teaching. He and they are in great demand throughout the Johns Hopkins Medical Institutions to teach faculty, fellows, and students the basics of research design, interpretation, and analysis. As part of this effort, Dr. Goodman teaches several courses in the Department of Epidemiology and participates in teaching the Methods in Clinical Research and Science of Clinical Investigation courses in the School of Medicine. He also serves on the faculties of the Center for Clinical Trials and of the Graduate Training Program in Clinical Investigation, to which the Oncology Center sends more fellows than any other department.

 

EM 5/06
 

Journal Citations

Gong, Z.; Neuhouser, M.L.; Goodman, P.J.; Albanes, D.; Chi, C.; Hsing, A.W.; Lippman, S.M.; Platz, E.A.; Pollak, M.N.; Thompson, I.M.; Kristal, A.R. Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1977-1983.
Hoque, M.O.; Begum, S.; Topaloglu, O.; Chatterjee, A.; Rosenbaum, E.; Van Criekinge, W.; Westra, W.H.; Schoenberg, M.; Zahurak, M.; Goodman, S.N.; Sidransky, D. Quantitation of promoter methylation of multiple genes in urine DNA and bladder cancer detection. J Natl Cancer Inst. 2006 Jul 19;98(14):996-1004.
Lucia, M.S.; Epstein, J.I.; Goodman, P.J.; Darke, A.K.; Reuter, V.E.; Civantos, F.; Tangen, C.M.; Parnes, H.L.; Lippman, S.M.; La Rosa, F.G.; Kattan, M.W.; Crawford, E.D.; Ford, L.G.; Coltman, C.A., Jr.; Thompson, I.M. Finasteride and high-grade prostate cancer in the Prostate Cancer Prevention Trial. J Natl Cancer Inst. 2007 Sep 19;99(18):1375-1383.
Carvalho, A.L.; Jeronimo, C.; Kim, M.M.; Henrique, R.; Zhang, Z.; Hoque, M.O.; Chang, S.; Brait, M.; Nayak, C.S.; Jiang, W.W.; Claybourne, Q.; Tokumaru, Y.; Lee, J.; Goldenberg, D.; Garrett-Mayer, E.; Goodman, S.; Moon, C.S.; Koch, W.; Westra, W.H.; Sidransky, D.; Califano, J.A. Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma. Clin Cancer Res. 2008 Jan 1;14(1):97-107.
Diehl, F.; Schmidt, K.; Choti, M.A.; Romans, K.; Goodman, S.; Li, M.; Thornton, K.; Agrawal, N.; Sokoll, L.; Szabo, S.A.; Kinzler, K.W.; Vogelstein, B.; Diaz, L.A., Jr. Circulating mutant DNA to assess tumor dynamics. Nat Med. 2008 Sep;14(9):985-990.
Diehl, F.; Schmidt, K.; Durkee, K.H.; Moore, K.J.; Goodman, S.N.; Shuber, A.P.; Kinzler, K.W.; Vogelstein, B. Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients. Gastroenterology. 2008 Aug;135(2):489-498.
Freeman, J.M.; Vining, E.P.; Kossoff, E.H.; Pyzik, P.L.; Ye, X.; Goodman, S.N. A blinded, crossover study of the efficacy of the ketogenic diet. Epilepsia. 2008 Aug 19.
Goodman, S.N. Systematic reviews are not biased by results from trials stopped early for benefit. Journal of clinical epidemiology. 2008 Jan;61(1):95-96; author reply 96-98.
Hoque, M.O.; Begum, S.; Brait, M.; Jeronimo, C.; Zahurak, M.; Ostrow, K.L.; Rosenbaum, E.; Trock, B.; Westra, W.H.; Schoenberg, M.; Goodman, S.N.; Sidransky, D. Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer. J Urol. 2008 Feb;179(2):743-747.
Kass, N.; Taylor, H.; Fogarty, L.; Sugarman, J.; Goodman, S.N.; Goodwin-Landher, A.; Carducci, M.; Hurwitz, H. Purpose and benefits of early phase cancer trials: what do oncologists say? What do patients hear? J Empir Res Hum Res Ethics. 2008 Sep;3(3):57-68.
Marchionni, L.; Wilson, R.F.; Wolff, A.C.; Marinopoulos, S.; Parmigiani, G.; Bass, E.B.; Goodman, S.N. Systematic review: gene expression profiling assays in early-stage breast cancer. Ann Intern Med. 2008 Mar 4;148(5):358-369.
Singh, A.; Boldin-Adamsky, S.; Thimmulappa, R.K.; Rath, S.K.; Ashush, H.; Coulter, J.; Blackford, A.; Goodman, S.N.; Bunz, F.; Watson, W.H.; Gabrielson, E.; Feinstein, E.; Biswal, S. RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res. 2008 Oct 1;68(19):7975-7984.
Sutcliffe, S.; Alderete, J.F.; Till, C.; Goodman, P.J.; Hsing, A.W.; Zenilman, J.M.; De Marzo, A.M.; Platz, E.A. Trichomonosis and subsequent risk of prostate cancer in the Prostate Cancer Prevention Trial. Int J Cancer. 2008 Nov 19.
Fackler, M.J.; Rivers, A.; Teo, W.W.; Mangat, A.; Taylor, E.; Zhang, Z.; Goodman, S.; Argani, P.; Nayar, R.; Susnik, B.; Sukumar, S.; Khan, S.A. Hypermethylated genes as biomarkers of cancer in women with pathologic nipple discharge. Clin Cancer Res. 2009 Jun 1;15(11):3802-3811.
Kasamon, Y.L.; Wahl, R.L.; Ziessman, H.A.; Blackford, A.L.; Goodman, S.N.; Fidyk, C.A.; Rogers, K.M.; Bolanos-Meade, J.; Borowitz, M.J.; Ambinder, R.F.; Jones, R.J.; Swinnen, L.J. Phase II study of risk-adapted therapy of newly diagnosed, aggressive non-Hodgkin lymphoma based on midtreatment FDG-PET scanning. Biol Blood Marrow Transplant. 2009 Feb;15(2):242-248.
Kass, N.E.; Sugarman, J.; Medley, A.M.; Fogarty, L.A.; Taylor, H.A.; Daugherty, C.K.; Emerson, M.R.; Goodman, S.N.; Hlubocky, F.J.; Hurwitz, H.I.; Carducci, M.; Goodwin-Landher, A. An intervention to improve cancer patients' understanding of early-phase clinical trials. Irb. 2009 May-Jun;31(3):1-10.
Li, M.; Chen, W.D.; Papadopoulos, N.; Goodman, S.N.; Bjerregaard, N.C.; Laurberg, S.; Levin, B.; Juhl, H.; Arber, N.; Moinova, H.; Durkee, K.; Schmidt, K.; He, Y.; Diehl, F.; Velculescu, V.E.; Zhou, S.; Diaz, L.A., Jr.; Kinzler, K.W.; Markowitz, S.D.; Vogelstein, B. Sensitive digital quantification of DNA methylation in clinical samples. Nat Biotechnol. 2009 Sep;27(9):858-863.
Platz, E.A.; Till, C.; Goodman, P.J.; Parnes, H.L.; Figg, W.D.; Albanes, D.; Neuhouser, M.L.; Klein, E.A.; Thompson, I.M., Jr.; Kristal, A.R. Men with low serum cholesterol have a lower risk of high-grade prostate cancer in the placebo arm of the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2807-2813.
Sutcliffe, S.; Alderete, J.F.; Till, C.; Goodman, P.J.; Hsing, A.W.; Zenilman, J.M.; De Marzo, A.M.; Platz, E.A. Trichomonosis and subsequent risk of prostate cancer in the Prostate Cancer Prevention Trial. Int J Cancer. 2009 May 1;124(9):2082-2087.
Brodsky, R.A.; Chen, A.R.; Dorr, D.; Fuchs, E.J.; Huff, C.A.; Luznik, L.; Smith, B.D.; Matsui, W.H.; Goodman, S.N.; Ambinder, R.F.; Jones, R.J. High-dose cyclophosphamide for severe aplastic anemia: long-term follow-up. Blood. 2010 Mar 18;115(11):2136-2141.
Kristal, A.R.; Arnold, K.B.; Neuhouser, M.L.; Goodman, P.; Platz, E.A.; Albanes, D.; Thompson, I.M. Diet, supplement use, and prostate cancer risk: results from the prostate cancer prevention trial. Am J Epidemiol. 2010 Sep 1;172(5):566-577.
Luznik, L.; Bolanos-Meade, J.; Zahurak, M.; Chen, A.R.; Smith, B.D.; Brodsky, R.; Huff, C.A.; Borrello, I.; Matsui, W.; Powell, J.D.; Kasamon, Y.; Goodman, S.N.; Hess, A.; Levitsky, H.I.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease. Blood. 2010 Apr 22;115(16):3224-3230.
Pattani, K.M.; Zhang, Z.; Demokan, S.; Glazer, C.; Loyo, M.; Goodman, S.; Sidransky, D.; Bermudez, F.; Jean-Charles, G.; McCaffrey, T.; Padhya, T.; Phelan, J.; Spivakovsky, S.; Bowne, H.Y.; Goldberg, J.D.; Rolnitzky, L.; Robbins, M.; Kerr, A.R.; Sirois, D.; Califano, J.A. Endothelin receptor type B gene promoter hypermethylation in salivary rinses is independently associated with risk of oral cavity cancer and premalignancy. Cancer Prev Res (Phila). 2010 Sep;3(9):1093-1103.
Platz, E.A.; Sutcliffe, S.; De Marzo, A.M.; Drake, C.G.; Rifai, N.; Hsing, A.W.; Hoque, A.; Neuhouser, M.L.; Goodman, P.J.; Kristal, A.R. Intra-individual variation in serum C-reactive protein over 4 years: an implication for epidemiologic studies. Cancer Causes Control. 2010 Jun;21(6):847-851.
Sutcliffe, S.; Viscidi, R.P.; Till, C.; Goodman, P.J.; Hoque, A.M.; Hsing, A.W.; Thompson, I.M.; Zenilman, J.M.; De Marzo, A.M.; Platz, E.A. Human papillomavirus types 16, 18, and 31 serostatus and prostate cancer risk in the Prostate Cancer Prevention Trial. Cancer Epidemiol Biomarkers Prev. 2010 Feb;19(2):614-618.
Zheng, W.; Danforth, K.N.; Tworoger, S.S.; Goodman, M.T.; Arslan, A.A.; Patel, A.V.; McCullough, M.L.; Weinstein, S.J.; Kolonel, L.N.; Purdue, M.P.; Shu, X.O.; Snyder, K.; Steplowski, E.; Visvanathan, K.; Yu, K.; Zeleniuch-Jacquotte, A.; Gao, Y.T.; Hankinson, S.E.; Harvey, C.; Hayes, R.B.; Henderson, B.E.; Horst, R.L.; Helzlsouer, K.J. Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol. 2010 Jul 1;172(1):70-80.

 

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