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Dr. Sandra Gabelli

Ph.D.
410-614-4145 (p)
Sandra Gabelli
Titles

Assistant Professor of Medicine
Assistant Professor of Oncology
Assistant Professor of Biophysics and Biophysical Chemistry
Assistant Professor of Art as applied to Medicine
 

Schools\Degrees

Ph.D Biophysics Johns Hopkins University

Training

Postdoctoral research, Structural Biology, Johns Hopkins University

Research Summary

Dr. Gabelli's research is focused on understanding the molecular mechanisms of signal transduction and oncogenic activation in the PI3K/mTOR pathways. She is also studying the isoprenoid pathway as a target of protozoan parasitic diseases.

Journal Citations

Gabelli SB, Bianchet MA, Bessman MJ, Amzel LM. The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family. Nat Struct Biol 2001 May;8(5):467-72.

Gabelli SB, Bianchet MA, Ohnishi Y, Ichikawa Y, Bessman MJ, Amzel LM. Mechanism of the E.coli ADP-ribose pyrophosphatase: A Nudix Hydrolase. Biochemistry 2002. Jul 30; 41 (30):9279-85.

Cho H, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW, Leahy DJ. Structure of the Extracellular region of HER2 Both Alone and in Complex with the Herceptin Fab. Nature. 2003 Feb 13;421(6924):756-60.
Kang LW, Gabelli SB, Bianchet MA, Xu, WL, Bessman, MJ, Amzel, LM. The structure of a Coenzyme A pyrophosphatase from Deinococcus Radiodurans: a member of the Nudix family. J Bacteriol. 2003 Jul;185(14):4110-8.
Kang LW, Gabelli SB, Cunningham, JE, O'Handley, SF, Amzel, LM. Structure and mechanism of MT-ADPRase, a Nudix hydrolase from Mycobacterium tuberculosis. Structure. 2003. Aug:11(8):1015-23.
Gabelli, SB, Bianchet, MA, Azurmendi, HF, Xia Z., Sarawat V., Mildvan, AS. , Amzel, LM. Structure and mechanism of GDP-mannose glycosyl hydrolase: a Nudix enzyme that cleaves at carbon instead of at phosphourus. Structure. 2004. Jun;12(6):927-35.

Mildvan AS, Xia Z, Azurmendi HF, Saraswat V, Massiah MA, Gabelli SB, Bianchet, Kang LW, Amzel LM. Structure and Mechanism of Nudix Hydrolases. Arch Biochem Biophys. 2005 Jan 1;433(1):129-43.
Xia Z, Azurmendi HF, Lairson LL, Withers SG, Gabelli SB, Bianchet MA, Amzel LM. Mildvan AS. Mutational, Structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction. Biochemistry 2005. Jun 28:44(24) 8989-8997.
Coblitz B, Shikano S, Wu M, Gabelli SB, Cockrell LM, Hanyu Y, Fu H, Amzel LM, Li M. Carboxyl-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors. J Biol Chem. 2005 Oct 28;280(43):36263-72 .
Nadella, M, Bianchet MA, Gabelli SB, Amzel LM. Structure and Activity of the Axon Guidance Protein MICAL. Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16830-5. Epub 2005 Nov 7. PMID: 16275926; PMCID: PMC1277968
Gabelli SB, McLellan J, Montalvetti A, Oldfield E, Docampo R, Amzel, LM. Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design. Proteins: Structure, Function and Bioinformatics. Jan 1;62(1):80-8. 2006.
Mildvan, AS, Xia Z, Azurmendi HF, Legler PM, Balfour MR, Lairson LL, Withers SG, Gabelli SB, Bianchet MA, and Amzel LM. Hydrogen Bonding in the Mechanism of GDP-Mannose Mannosyl Hydrolase. Journal of Molecular Structure. June 2006.

Gabelli SB, Bianchet MA, Xu W, Dunn CA, Niu ZD, Amzel LM, Bessman MJ. Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis. Structure. 2007 Aug;15(8):1014-22.

Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, Amzel LM. The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science 2007 Dec 14;318(5857):1744-8.
Huang CH, Mandelker D, Gabelli SB, Amzel LM. Insights into the oncogenic effects of /PIK3CA/ mutations from the structure of p110alpha/p85alpha. Cell Cycle. 2008 May 1;7(9):1151-6.

Bacha U, Barrila J, Gabelli SB, Kiso Y, Mario Amzel L, Freire E. Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro). Chem Biol Drug Des. 2008 Jul;72(1):34-49.
Amzel LM, Huang CH, Mandelker D, Lengauer C, Gabelli SB, Vogelstein B. Structural comparisons of class I phosphoinositide 3-kinases. Nat Rev Cancer. 2008 Sep;8(9):665-9.

Steyert SR, Messing SA, Amzel LM, Gabelli SB, Piñeiro SA. Identification of Bdellovibrio bacteriovorus HD100 Bd0714 as a Nudix dGTPase. J Bacteriol. 2008 Dec;190(24):8215-9.
Messing SA, Gabelli SB, Liu Q, Celesnik H, Belasco JG, Piñeiro SA, Amzel LM. Structure and biological function of the RNA pyrophosphohydrolase BdRppH from Bdellovibrio bacteriovorus. Structure. 2009 Mar 11;17(3):472-81.

Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM. A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16996-7001.

Huang CH, Gabelli SB, Oldfield E, Amzel LM. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer Proteins. Proteins. 2010 Mar;78(4):888-99.

Gabelli SB, Mandelker D, Schmidt-Kittler O, Vogelstein B, Amzel LM. Somatic mutations in PI3Kalpha: Structural basis for enzyme activation and drug design. Biochim Biophys Acta. 2010 Mar;1804(3):533-40.
Barrila J, Gabelli SB, Bacha U, Amzel LM, Freire E. Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CL(pro) .Biochemistry. 2010 May 25;49(20):4308-17.

Gabelli SB, Huang CH, Mandelker D, Schmidt-Kittler O, Vogelstein B, Amzel LM Structural Effects of Oncogenic PI3Kalpha Mutations. Curr Top Microbiol Immunol. 2010;347:43-53
Mohan S, Tse CM, Gabelli SB, Sarker R, Cha B, Fahie K, Nadella M, Zachos NC, Tu-Sekine B, Raben D, Amzel LM, Donowitz M. NHE3 activity is dependent on direct phosphoinositide binding at the N-terminus of its intracellular cytosolic region. J Biol Chem. 2010 Nov 5;285(45):34566-78.
Schmidt-Kittler O, Zhu JX, Yang J, Liu G, Hendricks W, Lengauer C, Gabelli SB, Kinzler KW, Vogelstein B, Huso DL, Zhou S. PI3Kα Inhibitors That Inhibit Metastasis. Oncotarget. 2010 Sep;1(5):339-48.
Messing SAJ, Gabelli SB, Echeverria I, Vogel JT, Guan JC, Tan BC, Klee HJ, McCarty DR, Amzel LM. Structural Insights into Maize Viviparous14, a Key Enzyme in the Biosynthesis of the Phytohormone Abscisic Acid. Plant Cell. Sep;22(9):2970-80.
Gabelli SB, Duong-Ly K, Brower ET, Amzel LM . Capitalizing on tumor genotyping: Towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase.Adv Enzyme Regul. 2011;51(1):273-9.
Duong-Ly KC, Gabelli SB, Xu W, Dunn CA, Schoeffield AJ, Bessman MJ, Amzel LM. The Nudix hydrolase CDP-Chase, a CDP-choline pyrophosphatase, is an asymmetric dimer with two distinct enzymatic activities. J Bacteriol. 2011 Jul;193(13):3175-85.
Boto AN, Xu W, Jakoncic J, Pannuri A, Romeo T, Bessman MJ, Gabelli SB, Amzel LM. Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition. Proteins. 2011 Aug;79(8):2455-66.

 

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