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Gastroenterology

1. Gastroparesis Registry 2 (GpR2): Continuation of the NIDDK Registry for the Characterization and Clinical Course of Gastroparesis Patients

The Gastroparesis Registry 2 is an observational study of patients with gastroparesis. This is the second registry study of gastroparesis started by the Gastroparesis Clinical Research Consortium funded by NIH. People with gastroparesis suffer from nausea, vomiting, stomach pain, feeling full after eating and/or losing weight. Why people develop gastroparesis is not known. People with diabetes, prior stomach surgery, or who have had certain viral infections seem to be at greater risk of developing this condition. The purpose of this study is to better understand gastroparesis and data collected may improve the understanding of the condition to enable better diagnosis and treatment.

We are seeking adults (18 and older) with symptoms of gastroparesis (nausea, vomiting, early satiety, fullness, abdominal pain). About 1000 people will take part in this study at 9 medical centers participating in this research study across the country. You will not receive drugs or medications as part of the Gastroparesis Registry 2. Study-related visits and procedures will be provided at no cost to you.

For more information about this study, please contact the study coordinator at 410-550-6871.

PI: Pankaj Jay Pasricha, M.D.
NA_00077378


2. Diabetes and Idiopathic Gastroparesis Efficacy, Safety and Tolerability Study (DIGEST)

We are seeking adults 18 to 75 years of age with a diagnosis of idiopathic or diabetic gastroparesis. This research study is being done to see how well people with gastroparesis tolerate an investigational study drug called velusetrag, to see how well it works to treat symptoms of gastroparesis, to determine how safe it is, and to measure how much of it gets into the blood. This study will look at whether taking velusetrag is better than a placebo in improving the symptoms of diabetic and idiopathic gastroparesis. This study will also look at the usefulness of having participants complete a questionnaire about their gastroparesis symptoms.

For more information about this study and to learn how you can participate, please contact the study manager at 410-550-6871.

PI: Pankaj Jay Pasricha, M.D.
NA_00069110

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