Karakousis Lab

  • The Karakousis Lab is primarily focused on understanding the molecular basis of Mycobacterium tuberculosis latency and reactivation. Major research activities include studying the adaptation of M. tuberculosis to stress conditions believed to be important in the infected human host as well as the phenomenon of phenotypic tolerance to antibiotics. We are actively investigating the regulatory cascade involved in the mycobacterial stringent response. Additionally, we are involved in preclinical drug screening in physiologically relevant animal models and focused on the development of novel molecular assays for the rapid diagnosis of latent TB infection and active TB disease, and for the detection of drug resistance.

    Research Areas: infectious disease, Mycobacterium tuberculosis, drugs, antibiotics, tuberculosis

    Lab Website

    Principal Investigator

    Petros Karakousis, M.D.

    Department

    Medicine