David MacGlashan Laboratory

  • Research in the Donald MacGlashan Laboratory aims to understand the regulation of secretion from human basophils and mast cells—two cells thought to play key roles in allergic reactions and other diseases. The hallmark reaction in these cells is degranulation through cell-bound IgE. Our interests lie in the signaling mechanisms that control this dramatic cell response and the factors that regulate the degree of the reaction.

    Research Areas: mast cells, allergies, basophils

    Principal Investigator

    Donald MacGlashan, M.D., Ph.D.

    Department

    Medicine