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The Johns Hopkins Russell H. Morgan Department of Radiology and Radiological Science advances the practice of medicine through the groundbreaking discoveries and translational research performed by our research faculty and physician scientists. Research advances and innovations happening in our laboratories foster the development of new medical imaging techniques, disease treatments and interventional procedures.
The Division of Cancer Imaging Research promotes preclinical and clinical multimodal imaging applications to understand and effectively treat cancer. Our work is dedicated to the applications of molecular imaging to understand cancer and the tumor environment. Previous research includes studying the tumor microenvironment using multimodal imaging for breast cancer models, developing mass spectrometry imaging and elucidate hypoxia-driven signaling pathways, and translating whole-body magnetic resonance imaging (MRI) from research to the clinical setting.
The Division of Magnetic Resonance Research serves as an interdisciplinary resource for NIH-funded investigators, clinicians and scientists from Johns Hopkins Medicine and others throughout the country. We encourage research innovation, as well as collaboration at the local, national and international level, and work to provide state-of-the-art technology to researchers and clinicians.
The Division of Medical Imaging Physics conducts state-of-the-art research in medical imaging physics, particularly in the areas of nuclear medicine, including PET and SPECT, CT and X-ray imaging. Our research aims to advance instrumentation technologies, image reconstruction techniques and image processing and analysis methods that lead to improved quality and quantitative accuracy in radiological images for better clinical diagnosis and other biomedical applications.
Research Labs and Centers
The Cellular Imaging Section is engineering cells to make them clinically visible in order to further understand diseases and develop treatments. Cells are manipulated with nanoparticles, contrast agents and reporter genes so that they can be followed and tracked with MRI and other noninvasive imaging techniques. The Cellular Imaging Section is using stem cell and immune cell therapy to find treatments for many diseases, including cancer, type 1 diabetes, ALS, multiple sclerosis, stroke and other neurological conditions.
The Center for Image-Guided Animal Therapy (CIGAT) is an advanced imaging facility specifically designed for the diagnosis and treatment of veterinary patients. The CIGAT also discovers novel diagnostics and treatments for veterinary patients through clinical trials and research studies. Veterinarians with expertise in performing advanced imaging procedures and anesthesia lead the team.
The Center for Translational Molecular Imaging (CTMI) serves as an Academic Research Organization (ARO) to develop and provide state-of-the-art imaging and therapeutic agents to address unmet medical needs to bring personalized medicine within the reach of patients. The CTMI addresses a variety of disorders including cancer, psychiatric and neurodegenerative diseases, cardiovascular disease, among others. Leveraging resources at Johns Hopkins University, the CTMI will generate new products through the offices of Technology Ventures and Business Development and Strategic Alliances.
The F. M. Kirby Research Center for Functional Brain Imaging is a research resource, where imaging scientists, neuroscientists and clinicians collaborate to study brain function. Research consists of image acquisition and analysis techniques, software development tools and databases for national research. Our team establishes a standard for best practices in the fields of data acquisition and analysis for a variety of MRI technologies, including functional MRI (fMRI), diffusion tensor MRI, MR spectroscopic imaging and computational anatomy.
The Technology Innovation Center (TIC) is a team of software designers and developers who use informatics to identify solutions to critical healthcare challenges. The TIC’s development team works to create and iteratively enhance software applications that improve patient care. Information technology products created by the TIC include decision support tools, an educational web-application suite and real-time graphical dashboards.
The In-vivo Cellular and Molecular Imaging Center conducts multidisciplinary research on cellular and molecular imaging related to cancer. We provide resources, such as consultation on biostatistics and bioinformatics and optical imaging and probe development, to understand and effectively treat cancer. Our molecular oncology experts consult on preclinical studies, use of human tissues, interpretation of data and molecular characterization of cells and tumor tissue.
The Office for Imaging Support in Translational Research is the imaging development core of the Johns Hopkins Institute for Clinical and Translational Research, responsible for providing imaging resources by developing a structure to facilitate collaborations between stakeholders in clinical and translational research. We facilitate access to imaging resources, assist with Internal Review Board (IRB) regulatory processes and consult on study design and implementation.
Radionuclide Therapy and Dosimetry Lab
The Radionuclide Therapy and Dosimetry Research Lab is focused on modeling and dosimetry analysis of radionuclide therapy to support the translation of novel targeted radionuclide therapy strategies to the clinic. The research is divided between laboratory studies and patient-specific dosimetry/radiobiological modeling studies. We provide the necessary preclinical data and analysis to translate alpha-emitter targeting of rapidly accessible metastatic disease to the clinic.
The Radiology Office of Research Administration and Training is committed to encouraging, facilitating and assisting staff, students, fellows and faculty of the Department of Radiology and its collaborators with its sponsored research and research training. Our goal is to foster the highest excellence in training new and current researchers, to provide new opportunities and to help submit new grant applications and maintain existing grants.
Clinical research and trials are a valuable component of the Johns Hopkins health care system — they benefit patients and help determine the safety and efficacy of new drugs and devices. Learn how you might be able to participate in a clinical trial at Johns Hopkins, either as a patient addressing a particular condition or as a healthy volunteer.
Small animal imaging is increasingly recognized as an important facet of preclinical and translational cancer research. Often the most significant leap forward that an already important biological study takes is when its results can be extended to the in vivo case — a necessary and often sufficient precondition for success in the clinic. We aim to provide that translational step and generate the confidence necessary to move new cancer therapies to patients.