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School of Medicine
Apathy in Dementia Study (ADMET II Trial)
Apathy is one of the most prevalent neuropsychiatric symptoms in individuals with Alzheimer’s disease.Up to 50% of people with dementia experience this loss of will and initiative, lack of interest in activities,lack of productivity, or lack of response to events in their life. The goal of the ADMET II study is to see ifmethylphenidate can help lessen the effects of apathy in Alzheimer’s disease. Also known as Ritalin, methylphenidate is approved for use in the treatment of attention Deficit/Hyperactivity Disorder by the FDA, and previous trials have suggested it may be helpful in treating apathy in Alzheimer’s disease. Individuals in the ADMET II trial will be asked to take methylphenidate or placebo for 6 months and attend about 7 clinic visits at Johns Hopkins at Bayview. If you are interested in learning more about this trial, call 410-550-9022. Principal Investigator: Paul Rosenberg, M.D. (JHU protocol number IRB00064958)
BDPP Treatment for Mild Memory Loss and Prediabetes
The combination of memory problems and abnormal blood sugar has been shown to be a risk factor for developing Alzheimer’s disease, and a nutraceutical (“health food”) is being investigated to target this problem. This trial is seeking individuals between the ages of 50-90 who are concerned that they may be experiencing memory loss. BDPP is a combination of resveratrol (a chemical found in the skin of grapes), grape seed extract, and Concord grape juice. Study investigators hope to learn if BDPP could help maintain memory or decrease the amount of abnormal proteins in the brain. Individuals in this study will be asked to take BDPP or placebo for 4 months and attend about 9 research visits to Johns Hopkins at Bayview. Glucose testing and a memory evaluation are provided as part of the trial. Please
call 410-550-9047 for more information on how to enroll.Principal investigator: Paul Rosenberg, M.D. (IRB protocol number IRB00062802)
Dietary Study for Older Adults with Mild Memory Impairment
Older adults with mild memory impairment (especially those with early Alzheimer’s disease) are needed for a research study of dietary treatments. This is 12-week clinical trial of a high-fat, low-carbohydrate diet vs. a low-fat diet high in fruits, vegetables and grains. Both diets are considered safe for most physically healthy older adults. All education, support, and vitamin supplements provided free of charge. You can stay on your existing medications. Your physician will be asked to agree to your participation. Johns Hopkins Medicine IRB # 00066092, Jason Brandt, Ph.D., Principal Investigator. For more information, please call Emilee Naylor at 410-955-1647. Download flyer.
MIND at Home Studies
Maximizing Independence (MIND) at Home is a comprehensive, home-based care coordination program designed to systematically assess and address the unmet needs of people with memory problems living at home and those of their family caregiver. The MIND at Home program provides education and links people in need of care to appropriate resources and services. Two MIND at Home studies—one funded by the Centers for Medicare & Medicaid Services and one funded by the National Institute on Aging—are now enrolling research volunteers. Goals of these studies are to find out if providing help in obtaining appropriate care for older adults with memory problems will help them remain at home longer and improve their quality of life. All study participants will receive an in-home needs assessment and a free written report with recommendations for care. Some participants will receive care coordination services for up to 18 months. If you or someone you know has a memory disorder and lives at home in Baltimore City, Howard or Baltimore Counties, and parts of Montgomery, Prince George’s, Anne Arundel, Carroll, and Harford Counties, with no plans to move in the next 6 months, they may be eligible to join a MIND at Home study. To learn more about these two studies, please call us at 410-550-6744 or email us at firstname.lastname@example.org. Principal Investigator: Quincy Samus, PhD (IRB Protocol Numbers: IRB00054802, IRB00041744). MIND Study Flyer | CMS Mind Study Flyer
Depression in Alzheimer’s Disease Study
People with Alzheimer’s disease can feel depressed. This condition is treatable with medication. Symptoms of depression can be loss of interest, feelings of hopelessness, persistent aches and pains, feeling sad, anxious or empty, loss of appetite, irritability, restlessness, insomnia or even excessive sleeping. We are conducting a research study to examine this and to see if a drug called venlafaxine may help. If you or someone you know is diagnosed with Alzheimer’s disease and experiencing feelings of depression, they may be eligible to participate in this study. If you are interested in learning more about this study please call 410-550-4258. Paul Rosenberg, M.D. Principal Investigator (JHU IRB Application #: NA_00066043)
Geriatric Depression Study
Are you over 60 and feeling depressed? Symptoms of depression in older adults are common yet often go undetected. Symptoms could include feelings of sadness or hopelessness, loss of energy, inability to enjoy pleasurable activities, changes in appetite or sleeping patterns, or poor concentration/memory. If you are feeling depressed, not taking antidepressant medication and in good physical health you may be eligible to participate in a research study involving treatment. Qualified people will participate at no cost to them and will be compensated for their time and transportation. For more information about the research study, please call us at 410-550-4192 or email us at BrainImagingStudy@lists.johnshopkins.edu . Principal Investigator: Gwenn Smith, PhD (IRB Protocol No: NA_00021615) Download PDF flyer
The Johns Hopkins Memory Center is currently conducting a study of the differences between normal aging, mild memory problems, and the onset of memory disorders like Alzheimer’s Disease. If you choose to participate in the Memory and Aging Study, you and a study partner will be invited to our clinic for a 2-3 hour assessment including memory testing, physical exam, and blood samples. We will ask you and your study partner questions about your daily functioning. You will return to our clinic once a year for an annual physical exam and memory testing. People, 60 years old or older, with or without memory problems, can participate in this study. If you are interested in learning more about this study please call Carolyn Koch at 410-550-9021. Constantine Lyketsos, MD, MPH,, Principal Investigator (JHU IRB Application No: NA_00045104)
Mild Cognitive Impairment Study
Are you more forgetful lately? Do you have trouble with the names of people you’ve met recently? Do you get lost in new places? Do you have a greater tendency to misplace things? Do other people notice that you are forgetful? If you are age 55 or over, having memory problems, not taking antidepressant medication and in good health, you may be eligible to participate in a research study. Qualified people will participate at no cost to them and will be compensated for their time and transportation. For more information about the research study, please call us at 410-550-4192 or email us at BrainImagingStudy@lists.johnshopkins.edu. (Principal Investigator: Gwenn Smith, PhD, IRB Protocol No: NA_00026190) Download flyer.
Oral Glucose Tolerance Test for Alzheimer’s Disease Biomarker Development
The purpose of this research is to find if there is a relationship between a chemical in the blood, which may be related to memory problems, and the body’s hormonal response from the pancreas, gut, and fat tissue after an oral glucose tolerance test. People with and without memory problems may join this study. The study involves a memory screening test and an oral glucose tolerance test. The results of these tests will help us with our research study related to memory, aging, and hormones. If you are interested in learning more about this study please call 410-550-4969. Esther Oh, M.D., Principal Investigator (JHU IRB Application No.: NA_00014837)