Stuart C. Ray

 

Department Affiliation: Primary: Medicine; Secondary: Viral Oncology; Health Sciences Informatics
Degree: M.D., Vanderbilt University
Rank: Professor
Telephone Number: 410-614-2891
Fax Number: 410-614-7564
E-mail address: sray@jhu.edu
School of Medicine Address: Rangos Building, Suite 530, 855 N. Wolfe Street, Baltimore, MD  21205

Computational Immunovirology of Chronic Viral Hepatitis  

Chronic viral hepatitis (due to HBV and HCV) is a major cause of liver disease worldwide, and an increasing cause of death in persons living with HIV/AIDS.  Our laboratory studies are aimed at better defining the host-pathogen interactions in these infections, with particular focus on humoral and cellular immune responses, viral evasion, inflammation, fibrosis progression, and drug resistance.  We are engaged in synthetic biology approaches to rational vaccine development and understanding the limits on the extraordinary genetic variability of HCV.

Representative Publications:

• Hermankova. M., Ray, S.C., Ruff, C., Powell, Davis M., Ingersoll, R., D’Aquila, R.T., Quinn, T.C., Siliciano, J.D., Siliciano, R.F., Persaud, D. Stasis in the drug resistance profiles of HIV-1 in the plasma of infected children and adults on protease inhibitor-containing combination therapy with <50 copies/ml of plasma HIV-1 RNA. JAMA 286(2): 196-207, 2001.  Pub Med Reference

• Mehta, S.H., Cox, A., Hoover, D.R., Wang, X.-H., Mao, Q., Ray, S., Strathdee, S.A., Vlahov, D., Thomas, D.L. Protection against persistence of Hepatitis C. Lancet 359(9316): 1478-1483, 2002.  Pub Med Reference

• Ruff, C.T., Ray, S.C., Kwon, P., Zinn, R., Pendleton, A., Hutton, N., Ashworth, R., Gange, S., Quinn, T.C., Siliciano, R.F., Persaud, D. Persistence of Wild Type Virus and Lack of Temporal Structure in the Latent Reservoir for HIV-1 in Pediatric Patients with Extensive Antiretroviral Exposure. J Virology 76(18): 9481-9492, 2002. Pub Med Reference

• Li, K., Foy, E., Ferreon, J.C., Nakamura, M., Ferreon, A.C.M., Ikeda, M., Ray, S.C., Gale, M., Lemon, S.M. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci (USA) 102(8): 2992-2997, 2005. Pub Med Reference  

• Cox, A.L., Mosbruger, T., Mao, Q., Liu, Z., Wang, X.H., Yang, H.C., Sidney, J., Sette, A., Pardoll, D., Thomas, D.L., Ray, S.C. Cellular immune selection with hepatitis C virus persistence in humans. J Exp Med 201(11):1741-1752, 2005. Pub Med Reference  

• Ray, S.C., Fanning, L., Wang, X.H., Netski, D.M., Kenny-Walsh, E., Thomas, D.L. Divergent and convergent evolution after a common-source outbreak of hepatitis C virus. J Exp Med 201(11):1753-1759, 2005. Pub Med Reference  

• Wang, X.H., Netski, D.M., Astemborski, J., Mehta, S.H., Torbenson, M.S., Thomas, D.L., Ray, S.C. Fibrosis Progression during Chronic Hepatitis C is Associated with Rapid Viral Evolution. J Virol 81(12):6513-6522, 2007. Pub Med Reference  

• Balagopal, A., Philp, F.H., Astemborski, J., Block, T.M., Mehta, A., Long, R., Kirk, G.D., Mehta, S.H., Cox, A.L., Thomas, D.L., Ray, S.C. Human Immunodeficiency Virus-related Microbial Translocation and Progression of Hepatitis C. Gastroenterology 135(1):226-233, 2008. Pub Med Reference  

• Dowd, K.A., Netski, D.M., Wang, X.H., Cox, A.L., Ray, S.C. Selection Pressure from Neutralizing Antibodies Drives Sequence Evolution during Acute Infection with Hepatitis C Virus. Gastroenterology 136(7):2377-2386, 2009. Pub Med Reference  

• Liu, L., Fisher, B.E., Dowd, K.A., Astemborski, J., Cox, A.L., Ray, S.C. Acceleration of HCV envelope evolution in humans is consistent with progressive humoral immune selection during the transition from acute to chronic infection. J Virology 84(10): 5067-5077, 2010.  Pub Med Reference    

Other graduate programs in which Dr. Ray participates:

Graduate Immunology Program