Department Affiliation: Primary: Radiology;
Secondary: Oncology; Radiation Oncology; Environmental Health Sciences; Pharmacology and Molecular Sciences; Psychiatry
Degree: M.D., Ph.D., University of Illinois at Urbana-Champaign
Rank: William R. Brody Professor of Radiology
Telephone Number: 410-955-2789
Fax Number: 443-817-0990
E-mail address: firstname.lastname@example.org
School of Medicine Address: Cancer Research Bldg. 2, Room 492, 1550 Orleans Street, Baltimore, MD 21231
Translational Molecular Imaging
Recent advances in molecular and cellular biology, the emergence of more sophisticated animal models of human disease and the development of sensitive, high-resolution imaging systems enable the study of pathophysiology noninvasively in unprecedented detail. The overall goal of our work is to develop new techniques and agents to study human disease through imaging. We concentrate on two areas, i.e., cancer and central nervous system processes. Our work extends from basic chemical and radiochemical synthesis to clinical translation.
Current synthetically oriented projects include the development of radiopharmaceuticals for positron emission tomography (PET) and single photon emission computed tomography (SPECT) as well as optical imaging agents to be used for surgical guidance and nanomedicines. Such agents typically bind receptors or enzymes. One major effort involves developing a series of urea derivatives that have a high affinity for the prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II, as leads for imaging agents for prostate cancer and psychiatric disease. Several of those agents are in clinical trials. We have recently embarked on a program to develop radioimmunodiagnostic and low molecular weight imaging agents for chemokine receptors, and have developed a general technique for molecular-genetic imaging and therapy of cancer.
Human PET studies are also a priority, and we have several protocols for studying neurotransmission and inflammation in a variety of central nervous system pathologies including AIDS dementia and traumatic brain injury. We have also developed new methods to image infection and to image and treat virs-associated tumors - both of which are in clinical trials underway at Johns Hopkins and elsewhere.
- Banerjee, S.R., Pullambhatla, M., Byun, Y., Nimmagadda, S., Foss, C.A., Green, G., Fox, J.J., Lupold, S.E., Mease, R.C., Pomper, M.G. Sequential SPECT and optical imaging of experimental models of prostate cancer with a dual modality inhibitor of the prostate-specific membrane antigen. Angew. Chem. Int. Edit. 2011, in press.
- Bhang, H.-E., Gabrielson, K.L., Laterra, J., Fisher, P.B., Pomper, M.G. Tumor-specific imaging through progression elevated gene-3 promoter-driven gene expression. Nat. Med. 17:123-129, 2011. Pub Med Reference
- Banerjee, S.R., Pullambhatla, M., Byun, Y., Nimmagadda, S., Green, G., Fox, J.J., Horti, A., Mease ,R.C., Pomper, M.G. (68)Ga-labeled inhibitors of Prostate-Specific Membrane Antigen (PSMA) for imaging prostate cancer. J. Med. Chem. 2010 Jun 22. Pub Med Reference
- Nimmagadda, S., Pullambhatla, M., Stone, K., Green, G., Bhujwalla, Z.M., Pomper, M.G. Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography. Cancer Res. 70(10):3935-44, 2010. Pub Med Reference
- Wang, H., Byun, Y., Barinka, C., Pullambhatla, M., Bhang, H.-E., Fox, J.J., Lubkowski, J., Mease, R.C., Pomper, M.G. Bioisosterism of urea-based GCPII inhibitors: synthesis and structure-activity relationships. Bioorg. Med. Chem. Lett. 20(1):392-7, 2010. Pub Med Reference
- Zhang, Y., Byun, Y., Ren, Y.R., Liu, J.O., Laterra, J., Pomper, M.G. Identification of inhibitors of ABCG2 by a bioluminescence imaging-based high-throughput assay. Cancer Res. 69:5867-75, 2009. Pub Med Reference
- Fu, D,, Tanhehco, Y., Chen, J., Foss, C.A., Fox, J.J., Chong, J.-M., Fukayama, M., Sgouros, G., Kowalski, J., Pomper, M.G., Ambinder, R.F. Bortezomib-induced enzyme-targeted radiotherapy in herpesvirus-associated tumors. Nat. Med. 14:1118-1122, 2008. Pub Med Reference
- Diaz, L.A., Foss, C.A., Thornton, K., Nimmagadda, S., Endres, C.J., Uzuner, O., Seyler, T.M., Ulrich, S.D., Conway, J., Bettegowda, C., Agrawal, N., Cheong, I., Zhang, X., Ladenson, P.W., Vogelstein, B.N., Mont, M.A., Zhou, S., Kinzler, K.W., Vogelstein, B., Pomper, M.G. Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PLoS One 2(10):e1007, 2007. Pub Med Reference
- Zhou, J., Neale, J.H., Pomper, M.G., Kozikowski, A.P. NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nat. Rev. Drug Discovery 4:1015-26, 2005. Pub Med Reference
- Bettegowda, C., Foss, C.A., Wang, Y., Fox, J., Zhou, S., Kinzler, K., Vogelstein, B., Pomper, M.G. Imaging bacterial infection in live animals with radiolabeled FIAU. Proc. Natl. Acad. Sci. USA 102:1145-51150, 2005. Pub Med Reference