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Craig W. Hendrix

Craig W. Hendrix

Department Affiliation: Primary: Medicine, Division of Clinical Pharmacology; Secondary: Pharmacology and Molecular Sciences, Division of Infectious Diseases, Epidemiology, Bloomberg School of Public Health
Degree: M.D., Georgetown University School of Medicine
Rank: Professor
Telephone Number: 410-955-9707
Fax Number: 410-955-9708
E-mail address: chendrix@jhmi.edu
School of Medicine Address: Blalock 569, 600 N. Wolfe Street, Baltimore, MD 21287 

Current research focuses on chemoprevention of HIV infection

Research focuses on clinical pharmacology of HIV chemoprevention with an emphasis on: (1) development of methods to assess distribution of topical HIV microbicides, CD4 cells, and HIV in the sites of sexual transmission; (2) PK-PD models of pre-exposure antiretroviral HIV prophylaxis; (3) development of methods to understand the compartmentalization of antiretroviral drugs and HIV within the male genital tract. Other research involves HIV pharmacology, fungal chemoprevention, and drug-drug interactions.

Representative Publications:

  • Louissaint, N.A., Nimmagadda, S., Fuchs, E.J., Bakshi, R.P., Cao, Y., Lee, L., Goldsmith, A.J., Caffo, B., Du, Y., King, K.E., Menendez, F.A., Torbenson, M.S., Hendrix, C.W.  Distribution of cell-free and cell-associated HIV surrogates in the colon following simulated receptive anal intercourse in men.  J Aquir Immune Defic Syndr. 59(1):10-17, 2012.  Pub Med Reference
     
  • Louissaint, N.A., Fuchs, E.J., Bakshi, R.P., Nimmagadda, S., Du, Y., Macura, K., King, K.E., Goldsmith, A.J., Caffo, B., Cao, Y., Anderson, J.R., Hendrix, C.W.  Distribution of cell-free and cell-associated HIV surrogates in the femal genital tract following simulated vaginal intercourse.  J Infect Dis. 205(5):725-32, 2012.  Pub Med Reference
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  • Lu, Y., Celum, C., Wald, A., Baeten, J.M., Cowan, F., Delany-Moretlwe, S., Reid, S.E., Hughes, J.P., Wilcox, E., Corey, L., Hendrix, C.W.  Acyclovir achieves lower concentration in African HIV-seronegative, HSV-2 seropositive women compared to non-African populations.  Antimicrob Agents Chemother. 56(5):2777-2779, 2012.  Pub Med Reference
     
  • Cao, Y.J., Caffo, B.S., Fuchs, E.J., Lee, L.A., Du, Y., Li, L., Bakshi, R.P., Macura, K., Khan, W.A., Wahl, R.L., Grohskopf, L.A., Hendrix, C.W.  Quantification of the spatial distribution of rectally applied surrogates for microbicide and semen in colon with SPECT imaging.  Br J Clin Pharmacol. 74(6):1013-22, 2012.  Pub Med Reference
     
  • Lu, Y., Hendrix, C.W., Bumpus, N.N.  Cytochrome P450 3A5 plays a prmominent role in the oxidative metabolism of the anti-HIV drug Maraviroc.  Drug Metabol Disp. 40(12):2221-30, 2012.  Pub Med Reference
     
  • Hendrix, C.W., Chen, B.A., Guddera, V., Hoesley, C., Justman, J., Nakabiito, C., Salata, R., Soto-Torres, L., Patterson, K., Minnis, A.M., Gandham, S., Gomez, K., Richardson, B.A., Bumpus, N.N.  Pharmacokinetic cross-over study in women comparing tenofovir vaginal gel and oral tablets in vaginal tissue and other anatomic compartments (MTN-001).  PLoS One 8(1):e55013, 2013.  Pub Med Reference
     
  • Fuchs, E.J., Grohskopf, L.A., Lee, L.A., Bakshir, R.P., Hendrix, C.W.  Quantitative assessment of altered rectal mucosal permeability due to rectally applied Nonoxynol-9, biopsy, and simulated intercourse.  J Infect Dis. 207(9)1389-96, 2013.  Pub Med Reference
     
  • Avery, L.B., Sacktor, N., McArthur, J.C., Hendrix, C.W.  Protein-free efavirenz is equivalent in cerebrospinal fluid and blood plasma: Applying the law of mass action to predict protein-free drug concentration.  Antimicrob Agents Chemother. 57(3):1409-1414, 2013.  Pub Med Reference
     
  • Louissaint, N.A., Cao, Y.J., Skipper, P.L., Liberman, R.G., Tannenbaum, S.R., Nimmagadda, S., Anderson, J.R., Everts, S., Bakshi, R.P., Fuchs, E.J., Hendrix, C.W.  Single dose pharmacokinetics of oral Tenofovir in plasma, peripheral blood mononuclear cells, colonic and vaginal tissue.  AIDS Res Hum Retroviruses, 2013.  [Epub ahead of print]  Peb Med Reference
     
  • Avery, L.B., Zarr, M., Bakshi, R.P., Siliciano, R.S., Hendrix, C.W.  Increasing extracellular protein concentration reduces intracellular antiretroviral drug concentration and antiviral effect.  AIDS Res Hum Retroviruses, 2013.  [Epub ahead of print]  Pub Med Reference
     
  • Leyva, F.J., Bakshi, R.P., Fuchs, E.J., Li, L., Caffo, B.S., Goldsmith, A.J., Carballo-Dieguez, A., Ventuneac, A., Du, Y., Leal, J., Lee, L.A., Torbenson, M.T., Hendrix, C.W.  Iso-osmolar enemas demontrate preferential gastrointestinal distribution, safety, and acceptability compared with hyper- and hypo-osmolar enemas as a potential delivery vehicle for rectal microbicides.  AIDS Res Hum Retroviruses, 2013 Jul 25.  [Epub ahead of print]

Other Graduate programs Dr. Hendrix participates in:

 
 
 
 
 
 

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