Craig W. Hendrix

Department Affiliation: Primary: Medicine, Division of Clinical Pharmacology; Secondary: Pharmacology and Molecular Sciences, Division of Infectious Diseases, Epidemiology, Bloomberg School of Public Health
Degree: M.D., Georgetown University School of Medicine
Rank: Professor
Telephone Number: 410-955-9707
Fax Number: 410-955-9708
E-mail address: chendrix@jhmi.edu
School of Medicine Address: Room 502 Harvey, 600 N. Wolfe Street, Baltimore, MD 21287

Current research focuses on chemoprevention of HIV infection

Research focuses on clinical pharmacology of HIV chemoprevention with an emphasis on: (1) development of methods to assess distribution of topical HIV microbicides, CD4 cells, and HIV in the sites of sexual transmission; (2) PK-PD models of pre-exposure antiretroviral HIV prophylaxis; (3) development of methods to understand the compartmentalization of antiretroviral drugs and HIV within the male genital tract. Other research involves HIV pharmacology, fungal chemoprevention, and drug-drug interactions.

Representative Publications:

Avery, L.B., Bakshi, R.P., Cao, Y.J., Hendrix, C.W. Evaluation of the male genital tract as a pharmacological sanctuary from efavirenz. Clin Pharm Ther. 90(1):151-6, 2011. Pub Med Reference
Keller, M.J., Madan, R.P., Torres, N.M., Cho, S., Kalyoussef, S., Shust, G., Mesquita, P.M.M., Louissaint, N.A., Eisinger, S., Chen, J., Cohen, H.W., Carroll, E.E., Lee., A.C., Soto-Torres, L., Hendrix, C.W., Herold, B.C. Tenofovir vaginal gel study identifies candidate biomarkers predictive of microbicide efficacy and safety. PloS One 6(1):e16475, 2010. Pub Med Reference
Ndovi, T.T., Choi, L., Caffo, B., Parsons, T., Baker, S., Zhao, M., Rohde, C., Hendrix, C.W. Quantitative assessment of seminal vesicle and prostate drug concentrations by use of a non-invasive method. Clin Pharmacol Ther. 80(2):146-58, 2006. Pub Med Reference

Fuchs, E.J., Lee, L.A., Torbenson, M.S., Parsons, T.L., Bakshi, R.P., Guidos, A.M., Wahl, R.L., Hendrix, C.W. Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission. J Infect Dis. 195(5):703-10, 2007. Pub Med Reference

Hendrix, C.W., Fuchs, E.J., Macura, K.J., Lee, L.A., Parsons, T.L., Bakshi, R.P., Khan, W.A., Guidos, A., Leal, J.P., Wahl, R. Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates. Clin Pharmacol Ther. 83(1): 97-105, 2008. Pub Med Reference

Cao, Y.J., Ndovi, T.T., Parsons, T.L., Guidos, A., Caffo, B., Hendrix, C.W. Effect of semen sampling frequency on seminal antiretroviral drug concentration. Clin Pharmacol Ther. 83(6):848-56, 2008. Pub Med Reference

Cao, Y.J., Hendrix, C.W. Male Genital Tract Pharmacology: Developments in Quantitative Methods to Better Understand a Complex Peripheral Compartment. Clin Pharmacol Ther. 83(3):401-12, 2008. Pub Med Reference

Cao, Y.J., Caffo, B., Choi, L., Radebaugh, C., Fuchs, E.J., Hendrix, C.W. Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirin. J Clin Pharmacol. 48(2):176-83, 2008. Pub Med Reference

Caffo, B., Crainiceanu, C., Deng, L., Hendrix, C.W. A Case Study in Pharmacologic Imaging Using Principal Curves in Single Photon Emission Computed Tomography. J American Statistical Assoc. 103(484):1470-80, 2008. Peb Med Reference

Hendrix, C.W., Cao, Y.J., Fuchs, E.J. Topical Microbicides to Prevent HIV: Clinical Drug Development Challenges. Ann Rev Pharmacol Toxicol. 49:349–75, 2009. Pub Med Reference

Goldsmith, J., Caffo, B., Crainiceanu, C., Reich, D., Chen, Y., Hendrix, C.W. Non-linear Tube Fitting for the Analysis of Anatomical and Functional Structures. Ann Appl Stat. 130(484):1470-80, 2008. Pub Med Reference

Other Graduate programs Dr. Hendrix participates in: