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Richard F. Ambinder

Richard Ambinder 

Department Affiliation: Primary: Oncology; Secondary: Pharmacology and Molecular Sciences; Pathology
Degree: M.D., Ph.D. Johns Hopkins University
Rank: James B. Murphy Professor
Telephone Number: 410-955-8839
Fax Number: 410-955-0960
E-mail address: ambinder@jhu.edu
School of Medicine Address: Room 389, Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21287

Virology in human cancer; antiviral therapy; antitumor therapy; lymphoma biology  

Epstein-Barr virus and Kaposi's sarcoma herpesvirus are found in association with a variety of cancers. Our laboratory studies are aimed at better defining the role(s) of the virus in the pathogenesis of these diseases and the development of strategies to prevent, diagnose or treat them. We have become particularly interested in the unfolded protein response in activation of latent viral infection. Among the notions that we are exploring is the possibility that activation of virus-encoded enzymes will allow the targeted delivery of radation. In addition, we are investigating a variety of virus-related biomarkers including viral DNA, antibody responses, and cytokine measurements that may be clinically relevant.

Representative Publications:

  • Shirley, C.M., Chen, J., Shamay, M., Li, H., Zahnow, C.A., Hayward, S.A., Ambinder, R.F. Bortezomib induction of C/EBPb mediates Epstein-Barr virus lytic activation in Burkitt's lymphoma. Blood. Prepublished online March 29, 2011; Pub Med Reference
  • Kasamon, Y.L., Jones, R.J., Gocke, C.D., Blackford, A.L. Seifter, E.J., Davis-Sproul, J.M., Gore, S.D., Ambinder, R.F. Extended follow-up of autologous bone marrow transplantation with 4-hydroperoxycyclophosphamide (4-HC) purging for indolent or transformed non-Hodgkin lymphomas. Biol. Blood Marrow Transplant. 2011 Mar; 17(3):365-73. Epub 2010 Jul 22. Pub Med Reference
  • Wagner-Johnston, N.D., Gellert, L., Gocke, C.D., Lemas, M.V., Lee, J., Martinez-Maza, O., Ambinder, R.F. Clonal immunoglobulin DNA in the plasma of patients with AIDS-lymphoma. Blood. 2011 Mar 9. Pub Med Reference
  • Lin, L., Lee, J.Y., Kaplan, L.D., Dezube, B.J., Noy, A., Krown, S.E., Levine, A.M., Yu, Y., Hayward, G.S., Ambinder, R.F. Effects of Chemotherapy in AIDS-Associated Non-Hodgkin's Lymphoma on KSHV DNA in Blood.  J Clin. Oncol. 27:2496-502, 2009. Pub Med Reference
  • Lechowicz, M., Dittmer, D.P., Lee, J.Y., Krown, S.E., Wachsman, W., Aboulafia, D., Dezube, B.J., Ratner, L., Said, J., Ambinder, R.F. Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic acid. Clin. Infect. Dis. 2009 Dec 15; 49(12):1946-9. Pub Med Reference
  • Jones, R.J., Gocke, C.D., Kasamon, Y.L., Miller, C.B., Perkins, B., Barber, J.P., Vala, M.S., Gerber, J.M., Gellert, L.L., Siedner, M., Lemas, M.V., Brennan, S., Ambinder, R.F., Matsui, W. Circulating clonotypic B cells in classic Hodgkin lymphoma. Blood 113(23):5920-5926, 2009. Pub Med Reference
  • Fu, D.X., Tanhehco, Y., Chen, J., Foss, C.A., Fox, J.J., Chong, J.M., Hobbs, R.F., Fukayama, M., Sgouros, G., Kowalski, J., Pomper, M.G., Ambinder, R.F. Bortezomib-induced enzyme-targeted radiation therapy in herpesvirus-associated tumors.  Nat. Med. 14(10):1118-1122, 2008. Pub Med Reference.
  • Spitzer, T.R., Ambinder, R.F., Lee, J.Y., Kaplan, L.D., Wachsman, W., Straus, D.J., Aboulafia, D.M., Scadden, D.T. Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020. Biol Blood Marrow Transplant 14(1):59-66, 2008. Pub Med Reference
  • Fu, D.X., Tanhehco, Y.C., Chen, J., Foss, C.A., Fox, J.J., Lemas, V., Chong, J.M., Ambinder, R.F., Pomper, M.G. Virus-associated tumor imaging by induction of viral gene expression. Clin. Cancer Res. 13(5):1453-1458, 2007. Pub Med Reference

  • Glaser, S.L., Keegan, T.H., Clarke, C.A., Trinh, M., Dorfman, R.F., Mann, R.B., DiGiuseppe, J.A.,  Ambinder, R.F. Exposure to childhood infections and risk of Epstein-Barr virus--defined Hodgkin's lymphoma in women. Int. J. Cancer. 115(4):599-605, 2005. Pub Med Reference
  • Keegan, T.H., Glaser, S.L., Clarke, C.A., Gulley, M.L., Craig, F.E., Digiuseppe, J.A., Dorfman, R.F., Mann, R.B., Ambinder, R.F. Epstein-Barr virus as a marker of survival after Hodgkin's lymphoma: a population-based study. J. Clin. Oncol. 23(30):7604-7613, 2005. Review. Pub Med Reference.

  • Chan, A.T., Tao, Q., Robertson, K.D., Flinn, I.W., Mann, R.B., Klencke, B., Kwan, W.H., Leung, T.W., Johnson, P.J., Ambinder, R.F. Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors. J. Clin. Oncol. 22(8):1373-1381, 2004. Pub Med Reference.

 


Other graduate programs in which Dr. Ambinder participates:


BCMB Program

Cellular and Molecular Medicine Graduate Program

 
 
 
 
 
 

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