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Darrell R. Abernethy, M.D., Ph.D.
Role of genetic polymorphisms of drug effectors that effect responses to cardiovascular drugs.
Richard F. Ambinder, M.D., Ph.D., Professor
Virology and human cancer; antiviral therapy; antitumor therapy; lymphoma pathogenesis and treatment; immunological approaches to virus-associated malignancies.
L. Mario Amzel, Ph.D., Professor
3-D structure of proteins: immunoglobulins and other binding proteins; ATP synthase; monoxygenases and dioxygenases quinone reductase.
J. Thomas August, M.D., Professor
Genetic immunotherapy of infectious diseases and cancer by targeting DNA encoded antigen chimeras to MHC II; MHC II antigen presentation; development of DNA vaccines; immune tolerance.
James C. Barrow, Ph.D., Associate Professor
Drug discovery for disorders of neurodeveloment.
Namandje N. Bumpus, Ph.D., Associate Professor
Drug Metabolism and preclinical drug development; small molecule mass spectrometry; targeted metabolomics; antiviral drug-induced toxicity; modulation of cellular signaling pathways by reactive metabolites.
Philip A. Cole M.D., Ph.D., Professor and Director
Chemical and biochemical approaches in the study of signal transduction, circadian rhythm, and gene regulation.
Ted M. Dawson, M.D., Ph.D., Professor
Molecular and cellular signals controlling neurodegeneration, neuronal survival and cell death.
Samuel R. Denmeade, M.D., Professor
Targeted therapies for cancer; prodrugs; proteases; peptide libraries.
Albena Dinkova-Kostova, Ph.D., Assistant Professor
Protection against cancer mechanisms and strategies; structure-activity relation of protective agents; inflammation and cancer; skin cancer prevention.
Kelly E. Dooley, M.D., Ph.D., Associate Professor
Clinical pharmacology of anti-infective agents; Evaluation of new drug regimens for the treatment of tuberculosis and co-treatment of TB and HIV.
Jed W. Fahey, Sc.D., Assistant Professor
Phytochemistry/nutrition-based prevention of chronic disease.
Charles W. Flexner, M.D., Professor
Basic and clinical pharmacology of antiretroviral drugs; HIV protease inhibitors and entry inhibitors.
Wade Gibson, Ph.D., Professor Emeritus
Herpesvirus proteins: studies of their expression, structure, and function using genetic, biochemical, and immunological approaches.
Marc M. Greenberg, Ph.D., Professor
Chemical and biochemical approaches to the study of DNA damage and repair, and their applications.
Justin Hanes, Ph.D., Professor
Nanotechnology for Drug and Nucleic Acid Delivery.
J. Marie Hardwick, Ph.D.,Professor
Molecular mechanisms of programmed cell death.
Gary S. Hayward, Ph.D., Professor
Pathways of herpesvirus gene regulation, latency and pathogenesis; enhancer and silencer elements that modulate gene expression; mechanisms of positive and negative transcriptional regulation; interaction with and targeting to subnuclear domains by viral regulatory proteins; molecular piracy and promotion of angiogenesis by Kaposi's sarcoma herpesvirus; virus evasion of interferon-mediated innate immunity; virus evolution and virus hunting.
S. Diane Hayward, Ph.D., Professor
Epstein-Barr virus and Kaposi's sarcoma virus; viral latency and tumorigenesis; mechanisms of virus-induced cell proliferation; viral mediated epigenetic modification of cell gene expression; notch and wnt pathways.
Ling He, M.D., Ph.D., Assistant Professor
Regulations of glucose and lipid metabolism by co-activators and metformin.
Craig W. Hendrix, M.D., Professor
Anti-infective drugs; chemoprevention of infectious diseases.
Richard L. Huganir, Ph.D., Professor
Molecular mechanisms in the regulation of synaptic plasticity.
Takanari Inoue, Ph.D., Associate Professor
Synthetic Cell Biology: Total synthesis of cellular functions such as neutrophil chemotaxis and ciliary mechano-sensation
John T. Isaacs, Ph.D., Professor
Anti-cancer drug development; Normal and malignant stem cell biology.
William B. Isaacs, Ph.D., Professor
Understanding the molecular genetic events responsible for initiation and progression of prostate cancer, with particular interest in inherited susceptibility to prostate cancer.
Elizabeth M. Jaffee, M.D., Professor
Analysis of antitumor immune responses against human tumors; identification of the targets of tumor-specific cytotoxic T cells.
David A. Kass, M.D., Professor
Molecular physiology of myocardial disease.
Kenneth W. Kinzler, Ph.D., Professor
Molecular genetics of cancer, translational cancer research.
Mark Levis, M.D., Ph.D., Associate Professor
Targeting the FLT3 signaling pathway as a treatment for acute leukemia.
Jun O. Liu, Ph.D., Professor
Chemical biology and molecular biology; use of small molecules as probes to elucidate mechanisms of signal transduction; angiogenesis and cell proliferation.
Caren L. Freel Meyers, Ph.D., Associate Professor
Organic and medicinal chemistry, chemical biology: drug delivery; study of non-mammalian isoprenoid biosynthesis; development of potential therapeutic agents for cancer and infectious disease.
William G. Nelson, M.D., Ph.D., Professor
Molecular mechanisms of prostatic carcinogenesis; epigenetic alterations in cancer; new approaches to prostate cancer prevention and treatment.
Duojia Pan, Ph.D., Professor
Growth control in normal development and cancer; signal transduction; animal models of cancer.
Brent Petty, M.D., Associate Professor
Antimicrobial chemotherapy; hospital-based medical practices; internal medicine collaboration with ophthalmologic clinical trials.
Kenneth J. Pienta, M.D., Professor
The ecology of cancer, tumor microenvironment, metastasis, biomarker development, novel therapeutic development.
Martin G. Pomper, M.D., Ph.D., Professor
In Vivo molecular and cellular imaging; radiopharmaceutical development; targeted cancer imaging and therapy; molecular brain imaging.
Jonathan D. Powell, M.D., Ph.D., Associate Professor
Mechanisms of T cell activation and tolerance.
Stuart C. Ray, M.D., Professor
Computational immunovirology of chronic viral hepatitis.
Douglas N. Robinson, Ph.D., Professor
Understanding cytokinesis and cell shape control.
Christopher A. Ross, M.D., Ph.D., Professor
Charles M. Rudin, M.D., Ph.D., Professor
Molecular mechanisms of apoptosis, roles of apoptosis in carcinogenesis and therapeutic resistance, novel therapeutic development in animal models of cancer.
Ronald L. Schnaar, Ph.D., Professor
Cell interactions in the nervous system.
Theresa A. Shapiro, M.D., Ph.D., Professor
Clinical pharmacology; molecular mechanisms of antiparasitic drug action; effects of topoisomerase inhibitors on DNA of trypanosomes; structure-activity of synthetic antimalarial trioxanes.
Robert F. Siliciano, M.D., Ph.D., Professor
HIV latency, evolution, and persistence; HIV treatment and drug resistance; pharmacology of HIV drugs.
Solomon H. Snyder, M.D., Professor
Molecular basis of neural signal transduction.
James T. Stivers, Ph.D., Professor
Structural and Chemical Biology of Uracil Metabolism and Applications to Cancer Therapy, Innate and Adaptive Immunity.
Saraswati Sukumar, Ph.D., Professor
Molecular alterations in breast cancer.
Paul Talalay, M.D., Professor
Molecular mechanisms involved in chemoprotection against mutagens and carcinogens.
Sean D. Taverna, Ph.D., Associate Professor
Histone and chromatin modifications, epigenetics and gene function, identification of histone binding modules, and small RNA directed gene silencing.
Craig A. Townsend, Ph.D., Professor
Organic and bioorganic chemistry: biosynthesis of natural products and biomimetic synthesis; elucidation of protein function; molecular biology of secondary metabolism and engineering of biosynthetic systems to practical ends; study of the role and inhibition of fatty acid synthesis in human cancer, tuberculosis, and obesity.
Bert Vogelstein, M.D., Professor
Molecular genetics of human cancer.
Srinivasan Yegnasubramanian, M.D., Ph.D., Associate Professor
Understanding and exploiting alterations in the cancer genome and epigenome for development of biomarkers and therapeutics.
Heng Zhu, Ph.D., Professor
Signal Transduction; protein network; host-pathogen interaction; biomarker identification.