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Publications of the Pain Faculty

Srinivasa Raja, MD - Pain Research DirectorDr. S. CohenDr. Erdek

PaulDr. Kayode Williams

Recent publications by our faculty members:

Cohen SP, Christo PJ, Wang S, Chen L, Stojanovic MP, Shields CH, Brummett C, Mao J. The effect of opioid dose and treatment duration on the perception of a painful standardized clinical stimulus. Reg Anesth Pain Med. 2008 May-Jun;33(3):199-206.

Cohen SP, Stojanovic MP, Crooks M, Kim P, Schmidt RK, Shields CH, Croll S, Hurley RW.  Lumbar zygapophysial (facet) joint radiofrequency denervation success as a function of pain relief during diagnostic medial branch blocks: a multicenter analysis. Spine J. 2008 May-Jun;8(3):498-504. Epub 2007 Jun 18.

Dahl E, Cohen SP. Perineural injection of etanercept as a treatment for postamputation pain. Clin J Pain. 2008 Feb;24(2):172-5.

Guan Y, Johanek LM, Hartke TV, Shim B, Tao YX, Ringkamp M, Meyer RA, Raja SN. Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury. Pain. 2008 Feb 12.

Cohen SP. Cannabinoids for chronic pain. BMJ. 2008 Jan 26;336(7637):167-8. Epub 2008 Jan 8.

Dworkin RH, Gnann JW Jr, Oaklander AL, Raja SN, Schmader KE, Whitley RJ. Diagnosis and assessment of pain associated with herpes zoster and postherpetic neuralgia.
J Pain. 2008 Jan;9(1 Suppl 1):S37-44. Review.

Wu CL, Raja SN. An update on the treatment of postherpetic neuralgia. J Pain. 2008 Jan;9(1 Suppl 1):S19-30. Review.

Polydefkis M, Raja SN. What can we learn from failed neuropathic pain trials? Neurology. 2008 Jan 22;70(4):250-1.

Cohen SP, Bajwa ZH, Kraemer JJ, Dragovich A, Williams KA, Stream J, Sireci A, McKnight G, Hurley RW.  Factors predicting success and failure for cervical facet radiofrequency denervation: a multi-center analysis. Reg Anesth Pain Med. 2007 Nov-Dec;32(6):495-503.

Cohen SP, Hurley RW.  The ability of diagnostic spinal injections to predict surgical outcomes. Anesth Analg. 2007 Dec;105(6):1756-75.

Cohen SP, Dragovich A. Intrathecal analgesia. Anesthesiol Clin. 2007 Dec;25(4):863-82, viii.

White RL, Cohen SP. Return-to-duty rates among coalition forces treated in a forward-deployed pain treatment center: a prospective observational study. Anesthesiology. 2007 Dec;107(6):1003-8.

Zhao C, Chen L, Tao YX, Tall JM, Borzan J, Ringkamp M, Meyer RA, Raja SN. Lumbar sympathectomy attenuates cold allodynia but not mechanical allodynia and hyperalgesia in rats with spared nerve injury. J Pain. 2007 Dec;8(12):931-7. Epub 2007 Aug 13.

Kudel I, Edwards RR, Kozachik S, Block BM, Agarwal S, Heinberg LJ, Haythornthwaite J, Raja SN. Predictors and consequences of multiple persistent postmastectomy pains.
J Pain Symptom Manage. 2007 Dec;34(6):619-27. Epub 2007 Jul 16.

Christo PJ, Hobelmann G, Maine DN. Post-herpetic neuralgia in older adults: evidence-based approaches to clinical management. Drugs Aging. 2007;24(1):1-19. Review.

Cohen SP, Hurley RW, Christo PJ, Winkley J, Mohiuddin MM, Stojanovic MP.  Clinical predictors of success and failure for lumbar facet radiofrequency denervation. Clin J Pain. 2007 Jan;23(1):45-52.

Hansen HC, McKenzie-Brown AM, Cohen SP, Swicegood JR, Colson JD, Manchikanti L. Sacroiliac joint interventions: a systematic review. Pain Physician. 2007 Jan;10(1):165-84. Review.

Cohen SP. Epidemics, evolution, and sacroiliac joint pain. Reg Anesth Pain Med. 2007 Jan-Feb;32(1):3-6.

Cohen SP, Villena F, Mao J. Two unusual cases of postamputation pain from Operation Iraqi Freedom. J Trauma. 2007 Mar;62(3):759-61.

Cohen SP, Raja SN. Pathogenesis, diagnosis, and treatment of lumbar zygapophysial (facet) joint pain. Anesthesiology. 2007 Mar;106(3):591-614.

Cohen SP, Dragovich A. Intrathecal analgesia. Med Clin North Am. 2007 Mar;91(2):251-70.

Guan Y, Yaster M, Raja SN, Tao YX. Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice.
Mol Pain. 2007 Oct 8;3:29.

Bianchi BR, El Kouhen R, Neelands TR, Lee CH, Gomtsyan A, Raja SN, Vaidyanathan SN, Surber B, McDonald HA, Surowy CS, Faltynek CR, Moreland RB, Jarvis MF, Puttfarcken PS.
[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor. J Pharmacol Exp Ther. 2007 Oct;323(1):285-93.

Agarwal S, Polydefkis M, Block B, Haythornthwaite J, Raja SN. Transdermal fentanyl reduces pain and improves functional activity in neuropathic pain states. Pain Med. 2007 Oct-Nov;8(7):554-62.

Cohen SP, Shockey SM, Carragee EJ. The efficacy of repeat intradiscal electrothermal therapy. Anesth Analg. 2007 Aug;105(2):495-8.

Stojanovic MP, Cheng J, Larkin TM, Cohen SP. Psychophysical measurements during lumbar discography: a heart rate response study. J Spinal Disord Tech. 2007 Jul;20(5):387-91.

Cohen SP, Wenzell D, Hurley RW, Kurihara C, Buckenmaier CC 3rd, Griffith S, Larkin TM, Dahl E, Morlando BJ.  A double-blind, placebo-controlled, dose-response pilot study evaluating intradiscal etanercept in patients with chronic discogenic low back pain or lumbosacral radiculopathy. Anesthesiology. 2007 Jul;107(1):99-105.

Sykes KT, White SR, Hurley RW, Mizoguchi H, Tseng LF, Hammond DL. Mechanisms responsible for the enhanced antinociceptive effects of mu-opioid receptor agonists in the rostral ventromedial medulla of male rats with persistent inflammatory pain. J Pharmacol Exp Ther. 2007;322(2):813-21. Epub 2007 May 9.

Cohen SP, Raja SN. The middle way: a practical approach to prescribing opioids for chronic pain. Nat Clin Pract Neurol. 2006 Nov;2(11):580-1.

Sharma A, Williams K, Raja SN. Advances in treatment of complex regional pain syndrome: recent insights on aperplexing disease. Curr Opin Anaesthesiol. 2006 Oct;19(5):566-72.

Cohen SP, Sireci A, Wu CL, Larkin TM, Williams KA, Hurley RW.  Pulsed radiofrequency of the dorsal root ganglia is superior to pharmacotherapy or pulsed radiofrequency of the intercostal nerves in the treatment of  chronic postsurgical thoracic pain. Pain Physician. 2006 Jul;9(3):227-35.

Cohen SP, Verdolin MH, Chang AS, Kurihara C, Morlando BJ, Mao J. The intravenous ketamine test predicts subsequent response to an oral dextromethorphan treatment regimen in fibromyalgia patients. J Pain. 2006 Jun;7(6):391-8.

Lin EE, Horasek S, Agarwal S, Wu CL, Raja SN. Local administration of norepinephrine in the stump evokes dose-dependent pain in amputees. Clin J Pain. 2006 Jun;22(5):482-6.

Guan Y, Borzan J, Meyer RA, Raja SN. Windup in dorsal horn neurons is modulated by endogenous spinal mu-opioid mechanisms. J Neurosci. 2006 Apr 19;26(16):4298-307.

Gottschalk A, Cohen SP, Yang S, Ochroch EA. Preventing and treating pain after thoracic surgery. Anesthesiology. 2006 Mar;104(3):594-600.

Chu YC, Guan Y, Skinner J, Raja SN, Johns RA, Tao YX. Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain. Pain. 2005 Dec 15;119(1-3):113-23. Epub 2005 Nov 16.

Cohen SP. Sacroiliac joint pain: a comprehensive review of anatomy, diagnosis, and treatment. Anesth Analg. 2005 Nov;101(5):1440-53.

Cohen SP. Doctors and interrogation. N Engl J Med. 2005 Oct 13;353(15):1633-4; author reply 1633-4.

Cohen SP, Griffith S, Larkin TM, Villena F, Larkin R. Presentation, diagnoses, mechanisms of injury, and treatment of soldiers injured in Operation Iraqi Freedom: an epidemiological study conducted at two military pain management centers. Anesth Analg. 2005 Oct;101(4):1098-103

Stojanovic MP, Dey D, Hord ED, Zhou Y, Cohen SP. A prospective crossover comparison study of the single-needle and multiple-needle techniques for facet-joint medial branch block.
Reg Anesth Pain Med. 2005 Sep-Oct;30(5):484-90.

Shimizu I, Iida T, Guan Y, Zhao C, Raja SN, Jarvis MF, Cockayne DA, Caterina MJ. Enhanced thermal avoidance in mice lacking the ATP receptor P2X3. Pain. 2005 Jul;116(1-2):96-108.

Pogatzki-Zahn EM, Shimizu I, Caterina M, Raja SN. Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain. Pain. 2005 Jun;115(3):296-307. Epub 2005 Apr 20.

Cohen SP, Larkin TM, Barna SA, Palmer WE, Hecht AC, Stojanovic MP. Lumbar discography: a comprehensive review of outcome studies, diagnostic accuracy, and principles. Reg Anesth Pain Med. 2005 Mar-Apr;30(2):163-83. Review.

Raja SN, Haythornthwaite JA. Combination therapy for neuropathic pain--which drugs, which combination, which patients? N Engl J Med. 2005 Mar 31;352(13):1373-5.

Cohen SP, Williams S, Kurihara C, Griffith S, Larkin TM. Nucleoplasty with or without intradiscal electrothermal therapy (IDET) as a treatment for lumbar herniated disc. J Spinal Disord Tech. 2005 Feb;18 Suppl:S119-24.

Cohen SP, Narvaez JC, Lebovits AH, Stojanovic MP. Corticosteroid injections for trochanteric bursitis: is fluoroscopy necessary? A pilot study. Br J Anaesth. 2005 Jan;94(1):100-6. Epub 2004 Oct 29.

Erdek MA, Staats PS. Chronic pain and thoracic surgery. Thorac Surg Clin. 2005 Feb;15(1):123-30. Review.

Tall JM, Raja SN. Dietary constituents as novel therapies for pain. Clin J Pain. 2004 Jan-Feb;20(1):19-26.

Erdek MA, Pronovost PJ. Improving assessment and treatment of pain in the critically ill. Int J Qual Health Care. 2004 Feb;16(1):59-64.

Cohen SP, Christo PJ, Moroz L. Pain management in trauma patients. Am J Phys Med Rehabil. 2004 Feb;83(2):142-61.

Kozikowski GP, Cohen SP. Lumbar puncture associated with pneumocephalus: report of a case. Anesth Analg. 2004 Feb;98(2):524-6,

Brown AK, Christo PJ, Wu CL. Strategies for postoperative pain management. Best Pract Res Clin Anaesthesiol. 2004 Dec;18(4):703-17.

Cohen SP, Chang AS, Larkin T, Mao J. The intravenous ketamine test: a predictive response tool for oral dextromethorphan treatment in neuropathic pain. Anesth Analg. 2004 Dec;99(6):1753-9

Wu CL, Hurley RW, Anderson GF, Herbert R, Rowlingson AJ, Fleisher LA. Effect of postoperative epidural analgesia on morbidity and mortality following surgery in medicare patients. Reg Anesth Pain Med. 2004 Nov-Dec;29(6):525-33; discussion 515-9.

Gottschalk A, Raja SN. Severing the link between acute and chronic pain: the anesthesiologist's role in preventive medicine. Anesthesiology. 2004 Nov;101(5):1063-5.

Cohen SP, Larkin TM, Chang AS, Stojanovic MP. The causes of false-positive medial branch (facet joint) blocks in soldiers and retirees. Mil Med. 2004 Oct;169(10):781-6.

Cohen SP, Mullings R, Abdi S. The pharmacologic treatment of muscle pain. Anesthesiology. 2004 Aug;101(2):495-526.

Cohen SP, Larkin T. Sedation with ketamine during intradiscal electrothermal therapy. Spine. 2004 Jul 15;29(14):1590-2.

Cohen SP, DeJesus M. Ketamine patient-controlled analgesia for dysesthetic central pain. Spinal Cord. 2004 Jul;42(7):425-8.

Cohen SP, Larkin TM, Carragee E. Transforaminal epidural steroid delivery and diagnosing the level of nerve root pathology: comments on Baker et al., Pain 103/1-2, 2003.
Pain. 2004 Jun;109(3):526-7; author reply 527-8.

Tao YX, Raja SN. Are synaptic MAGUK proteins involved in chronic pain? Trends Pharmacol Sci. 2004 Aug;25(8):397-400.

Tall JM, Seeram NP, Zhao C, Nair MG, Meyer RA, Raja SN. Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat. Behav Brain Res. 2004 Aug 12;153(1):181-8.

Tao F, Tao YX, Zhao C, Doré S, Liaw WJ, Raja SN, Johns RA. Differential roles of neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory hyperalgesia.
Neuroscience. 2004;128(2):421-30.

Christo PJ, Grabow TS, Raja SN. Opioid effectiveness, addiction, and depression in chronic pain. Adv Psychosom Med. 2004;25:123-37.

Grabow TS, Christo PJ, Raja SN. Complex regional pain syndrome: diagnostic controversies, psychological dysfunction, and emerging concepts. Adv Psychosom Med. 2004;25:89-101.

Wu CL, Hsu W, Richman JM, Raja SN. Postoperative cognitive function as an outcome of regional anesthesia and analgesia. Reg Anesth Pain Med. 2004 May-Jun;29(3):257-68.

Raja SN, Lowenstein E. The birth of opioid anesthesia. Anesthesiology. 2004 Apr;100(4):1013-5.

Block BM, Hurley RW, Raja SN.  Mechanism-based therapies for pain. Drug News Perspect. 2004 Apr;17(3):172-86.

Mansikka H, Zhao C, Sheth RN, Sora I, Uhl G, Raja SN. Nerve injury induces a tonic bilateral mu-opioid receptor-mediated inhibitory effect on mechanical allodynia in mice.
Anesthesiology. 2004 Apr;100(4):912-21.

Zhao C, Tall JM, Meyer RA, Raja SN. Antiallodynic effects of systemic and intrathecal morphine in the spared nerve injury model of neuropathic pain in rats. Anesthesiology. 2004 Apr;100(4):905-11.

Zhao C, Wacnik PW, Tall JM, Johns DC, Wilcox GL, Meyer RA, Raja SN. Analgesic effects of a soy-containing diet in three murine bone cancer pain models. J Pain. 2004 Mar;5(2):104-10.

Zhao CS, Tao YX, Tall JM, Donovan DM, Meyer RA, Raja SN. Role of mu-opioid receptors in formalin-induced pain behavior in mice. Exp Neurol. 2003 Dec;184(2):839-45.

Haythornthwaite JA, Clark MR, Pappagallo M, Raja SN. Pain coping strategies play a role in the persistence of pain in post-herpetic neuralgia. Pain. 2003 Dec;106(3):453-60.

Christo PJ. Opioid effectiveness and side effects in chronic pain. Anesthesiol Clin North America. 2003 Dec;21(4):699-713.

Erdek MA, Staats PS. Spinal cord stimulation for angina pectoris and peripheral vascular disease. Anesthesiol Clin North America. 2003 Dec;21(4):797-804.

Grabow TS, Tella PK, Raja SN. Spinal cord stimulation for complex regional pain syndrome: an evidence-based medicine review of the literature. Clin J Pain. 2003 Nov-Dec;19(6):371-83.

Pogatzki EM, Raja SN. A mouse model of incisional pain. Anesthesiology. 2003 Oct;99(4):1023-7.

Freedman BA, Cohen SP, Kuklo TR, Lehman RA, Larkin P, Giuliani JR. Intradiscal electrothermal therapy (IDET) for chronic low back pain in active-duty soldiers: 2-year follow-up.
Spine J. 2003 Nov-Dec;3(6):502-9.

Hord ED, Cohen SP, Cosgrove GR, Ahmed SU, Vallejo R, Chang Y, Stojanovic MP. The predictive value of sympathetic block for the success of spinal cord stimulation. Neurosurgery. 2003 Sep;53(3):626-32; discussion 632-3.

Cohen SP, Mao J. Is the analgesic effect of systemic lidocaine mediated through opioid receptors? Acta Anaesthesiol Scand. 2003 Aug;47(7):910-1.

Cohen SP, Abdi S. Lateral branch blocks as a treatment for sacroiliac joint pain: A pilot study. Reg Anesth Pain Med. 2003 Mar-Apr;28(2):113-9.

Cohen SP, Foster A. Pulsed radiofrequency as a treatment for groin pain and orchialgia. Urology. 2003 Mar;61(3):645.

Stojanovic MP, Zhou Y, Hord ED, Vallejo R, Cohen SP. Single needle approach for multiple medial branch blocks: a new technique. Clin J Pain. 2003 Mar-Apr;19(2):134-7.

Cohen SP, Larkin T, Abdi S, Chang A, Stojanovic M. Risk factors for failure and complications of intradiscal electrothermal therapy: a pilot study. Spine. 2003 Jun 1;28(11):1142-7.
Tao YX, Rumbaugh G, Wang GD, Petralia RS, Zhao C, Kauer FW, Tao F, Zhuo M, Wenthold RJ, Raja SN, Huganir RL, Bredt DS, Johns RA. Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. J Neurosci. 2003 Jul 30;23(17):6703-12.

Berde CB, Brennan TJ, Raja SN. Opioids: more to learn, improvements to be made. Anesthesiology. 2003 Jun;98(6):1309-12.

Tao F, Tao YX, Mao P, Zhao C, Li D, Liaw WJ, Raja SN, Johns RA. Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase. Neuroscience. 2003;120(3):847-54.

O'Gorman DA, Raja SN. Drug infusions for the diagnosis and treatment of chronic pain. Curr Pain Headache Rep. 2002 Dec;6(6):452-9.

Cohen SP, Larkin T, Polly DW Jr. A giant herniated disc following intradiscal electrothermal therapy. J Spinal Disord Tech. 2002 Dec;15(6):537-41.

Cohen SP, Abdi S. Venous malformations associated with central pain: report of a case. Anesth Analg. 2002 Nov;95(5):1358-60,

Panlilio LM, Christo PJ, Raja SN. Current management of postherpetic neuralgia. Neurologist. 2002 Nov;8(6):339-50.

Cohen SP, Larkin T, Fant GV, Oberfoell R, Stojanovic M. Does needle insertion site affect diskography results? A retrospective analysis. Spine. 2002 Oct 15;27(20):2279-83; discussion 2283.

Raja SN, Haythornthwaite JA, Pappagallo M, Clark MR, Travison TG, Sabeen S, Royall RM, Max MB. Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology. 2002 Oct 8;59(7):1015-21.

Wu CL, Raja SN. Optimizing postoperative analgesia: the use of global outcome measures. Anesthesiology. 2002 Sep;97(3):533-4.

Cluff R, Mehio AK, Cohen SP, Chang Y, Sang CN, Stojanovic MP. The technical aspects of epidural steroid injections: a national survey. Anesth Analg. 2002 Aug;95(2):403-8.

Parra MC, Nguyen TN, Hurley RW, Hammond DL.  Persistent inflammatory nociception increases levels of dynorphin 1-17 in the spinal cord, but not in supraspinal nuclei involved in pain modulation. J Pain. 2002 Aug;3(4):330-6.

Raja SN, Grabow TS. Complex regional pain syndrome I (reflex sympathetic dystrophy). Anesthesiology. 2002 May;96(5):1254-60.

Wu CL, Tella P, Staats PS, Vaslav R, Kazim DA, Wesselmann U, Raja SN. Analgesic effects of intravenous lidocaine and morphine on postamputation pain: a randomized double-blind, active placebo-controlled, crossover trial. Anesthesiology. 2002 Apr;96(4):841-8.

Stojanovic MP, Vu TN, Caneris O, Slezak J, Cohen SP, Sang CN. The role of fluoroscopy in cervical epidural steroid injections: an analysis of contrast dispersal patterns.
Spine. 2002 Mar 1;27(5):509-14.

Mansikka H, Zhou L, Donovan DM, Pertovaara A, Raja SN. The role of mu-opioid receptors in inflammatory hyperalgesia and alpha 2-adrenoceptor-mediated antihyperalgesia.
Neuroscience. 2002;113(2):339-49

Fuchs PN, Meyer RA, Raja SN. Heat, but not mechanical hyperalgesia, following adrenergic injections in normal human skin. Pain. 2001 Feb 1;90(1-2):15-23.

Shir Y, Raja SN, Weissman CS, Campbell JN, Seltzer Z. Consumption of soy diet before nerve injury preempts the development of neuropathic pain in rats. Anesthesiology. 2001 Nov;95(5):1238-44.

Cohen SP, Lubin E, Stojanovic M. Intravenous lidocaine in the treatment of hiccup. South Med J. 2001 Nov;94(11):1124-5.

Cohen SP, Abdi S. New developments in the use of tricyclic antidepressants for the management of pain. Curr Opin Anaesthesiol. 2001 Oct;14(5):505-11.

Ackley MA, Hurley RW, Virnich DE, Hammond DL.  A cellular mechanism for the antinociceptive effect of a kappa opioid receptor agonist. Pain. 2001 Apr;91(3):377-88.

Oh SB, Tran PB, Gillard SE, Hurley RW, Hammond DL, Miller RJ. Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J Neurosci. 2001 Jul 15;21(14):5027-35.

Shir Y, Campbell JN, Raja SN, Seltzer Z. The correlation between dietary soy phytoestrogens and neuropathic pain behavior in rats after partial denervation.
Anesth Analg. 2002 Feb;94(2):421-6.

Weng HR, Mansikka H, Winchurch R, Raja SN, Dougherty PM. Sensory processing in the deep spinal dorsal horn of neurokinin-1 receptor knockout mice. Anesthesiology. 2001 Jun;94(6):1105-12.

Shir Y, Sheth R, Campbell JN, Raja SN, Seltzer Z. Soy-containing diet suppresses chronic neuropathic sensory disorders in rats. Anesth Analg. 2001 Apr;92(4):1029-34.

Frank SM, El-Rahmany HK, Tran KM, Vu B, Raja SN. Comparison of lower extremity cutaneous temperature changes in patients receiving lumbar sympathetic ganglion blocks versus epidural anesthesia. J Clin Anesth. 2000 Nov;12(7):525-30.

Ali Z, Raja SN, Wesselmann U, Fuchs PN, Meyer RA, Campbell JN. Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain.
Pain. 2000 Nov;88(2):161-8.

Raja SN, Dougherty PM. Reversing tissue injury-induced plastic changes in the spinal cord: the search for the magic bullet. Reg Anesth Pain Med. 2000 Sep-Oct;25(5):441-4.

Frank SM, Raja SN, Bulcao C, Goldstein DS. Age-related thermoregulatory differences during core cooling in humans. Am J Physiol Regul Integr Comp Physiol. 2000 Jul;279(1):R349-54.

Tran KM, Frank SM, Raja SN, El-Rahmany HK, Kim LJ, Vu B. Lumbar sympathetic block for sympathetically maintained pain: changes in cutaneous temperatures and pain perception.
Anesth Analg. 2000 Jun;90(6):1396-401.

Mansikka H, Sheth RN, DeVries C, Lee H, Winchurch R, Raja SN. Nerve injury-induced mechanical but not thermal hyperalgesia is attenuated in neurokinin-1 receptor knockout mice.
Exp Neurol. 2000 Apr;162(2):343-9.

Pappagallo M, Oaklander AL, Quatrano-Piacentini AL, Clark MR, Raja SN. Heterogenous patterns of sensory dysfunction in postherpetic neuralgia suggest multiple pathophysiologic mechanisms. Anesthesiology. 2000 Mar;92(3):691-8.

Clark MR, Heinberg LJ, Haythornthwaite JA, Quatrano-Piacentini AL, Pappagallo M, Raja SN. Psychiatric symptoms and distress differ between patients with postherpetic neuralgia and peripheral vestibular disease. J Psychosom Res. 2000 Jan;48(1):51-7.

Raja SN, Campbell JN. Risk-benefit ratio for surgical sympathectomy: dilemmas in clinical decision making. J Pain. 2000 Winter;1(4):261-4.

Raja SN, Haythornthwaite JA. Anesthetic management of the elderly: measuring function beyond the immediate perioperative horizon. Anesthesiology. 1999 Oct;91(4):909-11.

Mansikka H, Shiotani M, Winchurch R, Raja SN. Neurokinin-1 receptors are involved in behavioral responses to high-intensity heat stimuli and capsaicin-induced hyperalgesia in mice.
Anesthesiology. 1999 Jun;90(6):1643-9.

Frank SM, Raja SN, Bulcao CF, Goldstein DS. Relative contribution of core and cutaneous temperatures to thermal comfort and autonomic responses in humans. J Appl Physiol. 1999 May;86(5):1588-93.

Fuchs PN, Roza C, Sora I, Uhl G, Raja SN. Characterization of mechanical withdrawal responses and effects of mu-, delta-and kappa-opioid agonists in normal and mu-opioid receptor knockout mice. Brain Res. 1999 Mar 13;821(2):480-6.

Ringkamp M, Eschenfelder S, Grethel EJ, Häbler HJ, Meyer RA, Jänig W, Raja SN. Lumbar sympathectomy failed to reverse mechanical allodynia- and hyperalgesia-like behavior in rats with L5 spinal nerve injury. Pain. 1999 Feb;79(2-3):143-53.

Ringkamp M, Grethel EJ, Choi Y, Meyer RA, Raja SN. Mechanical hyperalgesia after spinal nerve ligation in rat is not reversed by intraplantar or systemic administration of adrenergic antagonists. Pain. 1999 Feb;79(2-3):135-41.

Fuchs PN, Ringkamp M, Shiotani M, Raja SN. Sympathectomy decreases formalin-induced nociceptive responses independent of changes in peripheral blood flow.
Exp Neurol. 1999 Jan;155(1):95-102.

Grabow TS, Hurley RW, Banfor PN, Hammond DL.  Supraspinal and spinal delta(2) opioid receptor-mediated antinociceptive synergy is mediated by spinal alpha(2) adrenoceptors. Pain. 1999 Oct; 83(1):47-55.

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