Joo-Ho Shin, PhD
Joo-Ho Shin, PhD, is a postdoctoral fellow in the Department of Neurology and the Institute for Cell Engineering at the Johns Hopkins University School of Medicine. He has a strong background in genetics, neuroproteomics, biochemisty, and cellular/molecular biology. His research focuses on parkin biology in the pathogenesis of Parkinson’s disease. He contributed to the discovery that PARIS, a novel parkin substrate, plays an important role on Parkinson’s disease pathogenesis, for which he earned the Alfred Blalock young investigator award. Dr Shin is involved in Project 1 researching the mechanism by which PARIS specifically and selectively regulates target genes, to provide a novel strategy for blocking PARIS-mediated toxicity.
Saurav Brahmachari, PhD, is a postdoctoral fellow who has received his training in neurochemistry, neuroimmunology and neuropharmacology with particular emphasis on understanding the molecular mechanisms of neurodegeneration. Dr Brahmachari has expertise in cell biology, protein biochemistry and immune histochemistry and cytochemistry. He uses this expertise to evaluate and characterize the phosphorylation of alpha-synuclein by c-Abl in PD and mouse models of alpha-synucleinopathy. His studies will provide new mechanistic insights into alpha-synucleinopathy and Parkinson’s disease. Dr Brahmachari is collaboratively involved in Project 1 and Project 2. He is responsible for conducting experiments described in Aim 3 of Project 1 and Aims 2 and 3 of Project 2. He is supervised by Dr Ted Dawson and Dr Han Soek Ko.
Yulan Xiong, PhD
Yulan Xiong, PhD, is a postdoctoral fellow who has received her training in genetics, cell biology, molecular biology and protein biochemistry. Dr Xiong has expertise in developing molecular and cellular models of Parkinson’s disease. She uses her expertise in yeast, fly and mouse genetics to study LRRK2 biology in Parkinson’s disease. She has developed a robust yeast model of LRRK2-induced toxicity and her results provide new insights into the basic pathobiology of LRRK2. Dr Xiong is responsible for conducting the experiments described in Aims 1, 2 and 4 of Project 3. She is supervised by Dr Valina L. Dawson.
Jonathan Nestor, BS
Jonathan Nestor, BS, has received a bachelor’s of science degree in Biology from the University of Maryland, Baltimore County.
He will be responsible for generating the cohorts of Tg mice and bigenic mice required for the proposed studies, day-to-day care, and the behavioral observation of Tg and bigenic mice cohorts, and the perfusion of mice for histological analysis. Mr. Nestor will also aid in biochemical and protein chemical experiments. Learn more about Project 2.
To contact Mr Nestor, email him at jnestor4(at)jhmi(dot)edu.