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Thomas Kosztowski

Medical Student
The Johns Hopkins University School of Medicine

Thomas Kosztowski

Thomas Kosztowski, currently a medical student in his last year at The Johns Hopkins University School of Medicine, expects to receive his medical degree in May 2010. Mr. Kosztowski obtained degrees in both chemistry and molecular and cellular biology from The University of Illinois in Urbana-Champaign in 2005.

Thomas was a recipient of the Howard Hughes Research Training Fellowship from 2008-2009 and has been studying the effect of platelet-derived growth factor receptor (PDGFR) has on the growth and migration of glioblastoma multiforme (GBM) brain tumor stem cells. He is exploring whether decreasing the expression of PDGFR with shRNA will affect the growth and invasion of brain tumor stem cells. Additionally, the downstream signaling pathways through which PDGFR regulates growth and migration in these brain tumor stem cells are being explored.  Lastly, Thomas has profound interest in studying the interaction between PDGFR and PTEN mutations in human neural stem cells from the subventricular zone and whether these mutations increase the likelihood of neural stem cells becoming brain tumor stem cells.


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