Director, JHU NIMH Surrogate Markers Core
Associate Professor of Neurology, Johns Hopkins University
Dr Norman Haughey received his PhD in Pharmacology from the University of Manitoba in 1998. He then completed one year of post-doctoral training at the University of Kentucky's Center on Aging before moving to the National Institute on Aging, Gerontology Research Center for an additional two years of fellowship. Dr Haughey joined the faculty of the Department of Neurology at Johns Hopkins in 2002.
Now an Associate Professor at Hopkins, Dr Haughey is a member of the JHU NIMH Center with specialization in Neurovirology and Neuroregeneration. His research focuses on signaling pathways that promote the dysfunction and death of neuronal cells. In this context, he is interested in the mechanisms that promote neurotoxic processes in HIV and Alzheimer's related dementias.
Dr Haughey and his colleagues use a multidisciplinary approach including tissue culture, molecular reconfiguration, transgenic or knock-out mice and biochemical approaches in order to identify and modify signal transduction pathways that are associated with neurodegenerative processes. Using these model systems, they have described pathogenic modifications of calcium permeable receptors and transporters that promote excessive calcium accumulation.
Current research is focused on mapping perturbations in lipid raft based signal transduction pathways that lead to the oxidative modification of subcellular targets involved in apoptotic and anti-apoptotic signaling.
A second research interest is in the biology of neural stem and neural progenitor cells. In particular, he is interested in the mechanisms that govern the function and survival of neural stem and neural progenitor cells and how these processes are disrupted in neurodegenerative conditions. These interests relate directly to diagnostics, therapeutics, cellular and molecular dynamics.