Goals and Objectives
The overarching theme of the Center is the development of novel therapeutics targeting sustained CNS inflammation for HIV-associated neurocognitive disorders (HAND). We have identified this as a high priority on the basis of our institutional strengths, our studies of neuropathogenesis, and the continuing importance in clinical care of these disorders.
Organization of the Administrative Core
The Administrative Core consists of the Executive Committee, an Operations Office, and an External Advisory Committee (EAC) to provide ‘high-altitude’ guidance and oversight. The Executive Committee consists of the Director, Co-Directors, and an administrator for the Center. Policies and procedures to be used by the Center are included in the Research Plan, and as Appendix material.
Objectives of the Administrative Core
To facilitate the development of novel therapeutics for HIV-associated neurocognitive disorders by facilitating collaborative research in HIV-related neuroscience among the widest possible range of the JHU academic community; increasing resources for HIV-related neuroscience; enhancing the productivity of HIV-related neuroscience research locally, nationally and internationally; encouraging high-risk, innovative ‘developmental’ research; encouraging and provide resources for new investigators; and providing educational resources for non-neurologists involved in HIV care for HIV-related neurological complications, and to facilitate participation in research.
The core will also be responsible for the development of a web-based, interactive “virtual cohort” to assemble individuals in the USA with HAND.
Aims of the Administrative Core
The specific aims of the Administrative Core will be to:
- Provide integration and coordination of the scientific leadership of the Center across Cores, affiliated faculty, and other institutional partners.
- Oversee and coordinate the various research programs that will form key components of the Center’s scientific activities.
- Manage and monitor the Center’s budget, assuring excellent stewardship of the Center’s funds.
- Provide ongoing assessment of the productivity and impact of the Center’s cores by conducting regular reviews of core outputs and accomplishments and re-budgeting funds on the basis of scientific priority and productivity.
- Provide the central web and communications platforms for all Center users, maintain the communications infrastructure, and monitor its usage.
- The Core will also facilitate, encourage and support linkages of the JHU Center with other HIV research programs, clinical trials organizations, CFARs and organizations with relevant missions, including local HIV public health and clinical services.
- The Core will also create a US-based “virtual cohort” to identify men and women at risk HAND (self-identified by having cognitive symptoms) and follow them prospectively to document the evolution of symptoms. The principal objective of the virtual cohort will be to expand our existing physical cohort, and facilitate recruitment into national clinical trials of HAND.