The overarching theme of the Center is the development of novel therapeutics targeting sustained CNS inflammation for HIV-associated neurocognitive disorders (HAND). We have identified this as a high priority on the basis of our institutional strengths, our studies of neuropathogenesis, and the continuing importance in clinical care of these disorders.
Goals and Objectives of the Administrative Core:
- Provide integration and coordination of the scientific leadership of the Center across Cores, affiliated faculty, and other institutional partners.
- Oversee and coordinate the various research programs that will form key components of the Center’s scientific activities.
- Manage and monitor the Center’s budget, assuring excellent stewardship of the Center’s funds.
- Provide ongoing assessment of the productivity and impact of the Center’s cores by conducting regular reviews of core outputs and accomplishments and re-budgeting funds on the basis of scientific priority and productivity.
- Provide the central web and communications platforms for all Center users, maintain the communications infrastructure, and monitor its usage.
- The Core will also facilitate, encourage and support linkages of the JHU Center with other HIV research programs, clinical trials organizations, CFARs and organizations with relevant missions, including local HIV public health and clinical services.
- The Core will also create a US-based “virtual cohort” to identify men and women at risk of HAND (self-identified by having cognitive symptoms) and follow them prospectively to document the evolution of symptoms. The principal objective of the virtual cohort will be to expand our existing physical cohort, and facilitate recruitment into national clinical trials of HAND.