Our projects are in two main areas of brain cancer research. Our first goal, since the inception of the laboratory, has been to identify genes that cause brain cancers. In particular, we have identified genes that are part of the basis of the formation of glioblastomas and medulloblastomas. Starting about four years ago, we sought practical applications for our research and embarked on an ambitious plan to identify new and better anti-cancer drugs. Our goal is to target the molecular changes that result in brain and other cancers. This work includes screening small molecules for new leads.