Mapping auditory cortex
Intracranial mapping methods (electrocorticography, electrocortical stimulation) are combined with behavioral paradigms to investigate the functional organization of human auditory cortex. This research focuses on functional mapping of auditory association areas in the lateral temporal lobe. Our clinical studies involve multi-electrode intracranial recordings with pre-surgical epilepsy patients who have normal or impaired auditory function (RO1-DC005645).
Auditory neural encoding and decoding
Advanced signal processing and statistical modeling methods are used to characterize stimulus-specific patterns of cortical auditory event-related responses. Single-channel and multi-channel analyses are performed, using time-domain and time-frequency methods, to determine the spatiotemporal response properties of cortical networks involved in processing simple and complex sounds including speech. One aim of these studies is to elucidate the role of high-frequency (gamma band) neural modulations in cortical sound processing. These studies are conducted in collaboration with researchers at NIH-NIDCD and Tsinghua University, China.
Measuring and modeling neural variability
Repeated measures electrophysiology recordings (scalp, intracranial), with simple and complex auditory stimuli, are performed to examine the variability and reliability of cortical auditory event-related responses. Changes in the spatiotemporal distributions of cortical auditory response patterns are measured as a function of time, individual listening abilities, and acoustic sound properties. We are developing new methods to quantify and model variability in brain mapping data in collaboration with the department of Biostatistics at Johns Hopkins Bloomberg School of Public Health (K24-DC010028).