Neurotherapeutics Course

ME: 200.703

This course is a newly devised graduate course in the School of Medicine, sponsored by the JHU NIMH Center to provide an overview of Therapeutic Development for neurological diseases.

The course will focus on preclinical drug development and will include the necessary phases involved in this process, including Idea Conception, Exploratory Research, Medicinal Chemistry, Drug Screening, Protection of Intellectual Property, Development of Surrogate Markers and the role of Regulatory Affairs. This will be followed up with specific examples of drug development for specific neurodegenerative disorders including Parkinson’s Disease, Alzheimer’s Disease, Huntington’s Disease, ALS, Peripheral Neuropathy, and HIV-associated Neurocognitive Disorders (HAND).

The course Director is Joseph Steiner, Ph.D., and Norman Haughey, Ph.D. is Co-director.  Expert guest lecturers are scheduled each week.

COURSE FORMAT: 1 hour TAPED LECTURES and 1 hour LIVE SUMMARY or JOURNAL CLUB.

For more information contact Joseph Steiner at jsteine3@jhmi.edu or Norman Haughey at nhaughe1@jhmi.edu.

Previous Neurotherapeutics lectures included:

• Exploratory Research/Target Validation
  Lecturer: Dr. Paul Jackson, J&J Pharmaceutical Inc.
• Drug Screening
  Lecturer:  Dr. Camilo Rojas, BSI
• Medicinal Chemistry Lead ID/Optimization
  Lecturer:  Dr. Dana Ferraris, BSI
• In Vivo Proof of Concept: Animal Models
  Lecturers: Dr. Douglas Kerr, JHU, Rita Sattler, JHU
• Biopharmaceutics: Pharmacokinetics
  Lecturer: Dr. Norman Haughey, JHU
• BBB permeability
  Lecturer: Dr. Monique Stins, JHU
• Regulatory Affairs-pre-IND through NDA
  Lecturer: Dr. Gerald Dal Pan, FDA
• Human Clinical Studies
  Lecturer: Dr. Justin McArthur, JHU
• Surrogate Markers
  Lecturer: Dr. Avi Nath, JHU
• Drug Development for Parkinson’s Disease
  Lecturer: Dr. Ted Dawson, JHU
• Drug Development for ALS
  Lecturer: Dr. Jeff Rothstein, JHU
• Drug Development for Alzheimer’s Disease
  Lecturer: Dr. Don Price, JHU
• Drug Development for Huntington’s Disease
  Lecturer: Dr. Chris Ross, JHU
• Drug Development for HIV-associated cognitive disorders
  Lecturer: Dr. Joe Steiner, JHU
• Drug Development for Peripheral Neuropathy
  Lecturer: Dr. Ahmet Hoke, JHU
• Biologics Development
  Lecturer: Dr. Susan Goelz, Biogen-Idec
• Neural Instruments
  Lecturer: Dr. Nitish Thakor, JHU
• Stem Cells as Therapeutics
  Lecturer: Dr. Hongjun Song, JHU