Search the Health Library
Get the facts on diseases, conditions, tests and procedures.
I Want To...
I Want To...
Find Research Faculty
Enter the last name, specialty or keyword for your search below.
School of Medicine
Studying mice, scientists at Johns Hopkins have fortified evidence that a key purpose of sleep is to recalibrate the brain cells responsible for learning and memory so the animals can “solidify” lessons learned and use them when they awaken — in the case of nocturnal mice, the next evening.
Researchers report they have discovered how two problem proteins known to cause Parkinson’s disease are chemically linked, suggesting that someday, both could be neutralized by a single drug designed to target the link. A report on their discovery appears in the Jan. 24 issue of Cell Reports.
Biomedical engineers at Johns Hopkins report they have worked out a noninvasive way to release and deliver concentrated amounts of a drug to the brain of rats in a temporary, localized manner using ultrasound. The method first “cages” a drug inside tiny, biodegradable “nanoparticles,” then activates its release through precisely targeted sound waves, such as those used to painlessly and noninvasively create images of internal organs.
Experiments in mice by researchers at Johns Hopkins suggest that if the goal is to ease or extinguish fearful emotional memories like those associated with post-traumatic stress disorder, alcohol may make things worse, not better. Results of their study demonstrate, they say, that alcohol strengthens emotional memories associated with fearful experiences and prevents mice from pushing aside their fears.
Johns Hopkins researchers along with academic and drug industry investigators say they have identified a new biological target for treating spinal muscular atrophy. They report they have evidence that an experimental medicine aimed at this target works as a “booster” in conjunction with a drug called nusinersen that was recently FDA-approved to improve symptoms of the disorder in mice.
Johns Hopkins Medicine today announced a collaborative agreement with Under Armour Inc. that introduces evidence-based science along with expert insights to the Under Armour Connected Fitness™ platform, which includes a suite of health and fitness applications: UA Record™, MapMyFitness®, MyFitnessPal® and Endomondo™.
A clump of just a few thousand brain cells, no bigger than a mustard seed, controls the daily ebb and flow of most bodily processes in mammals — sleep/wake cycles, most notably. Now, Johns Hopkins scientists report direct evidence in mice for how those cell clusters control sleep and relay light cues about night and day throughout the body.
In experiments on mice with a form of aggressive brain cancer, Johns Hopkins researchers have shown that localized chemotherapy delivered directly to the brain rather than given systemically may be the best way to keep the immune system intact and strong when immunotherapy is also part of the treatment.
The holidays are a time for family, fun and happiness. They are usually spent with the ones we love reflecting on the past year and feeling grateful. However, even with all the joy, the holidays can cause quite a large amount of stress. Whether it be trying to forgive someone for a mishap, trying not to let your worries impact your sleep, dealing with the dark and gloomy days, or merely learning the joys of giving, our experts are here with tips on how to make this holiday season a little brighter.
In a small study of young or recently retired NFL players, researchers at Johns Hopkins report finding evidence of brain injury and repair that is visible on imaging from the players compared to a control group of men without a history of concussion.
A headache can be just a migraine, or it can be something more. It could be caused by a number of different health concerns: allergies, stress or possibly worse — a stroke. Headaches are just one of the many symptoms that often lead doctors to misdiagnose a medical issue. Research shows that diagnostic errors affect roughly one in 20 adults in the U.S., or 12 million Americans a year. As many as one-third of these errors may result in serious permanent injuries, including disability or death.
A robotic arm and a virtual game were essential tools in a new study from researchers at Johns Hopkins Medicine. The study results suggest that while training doesn’t change neurological repair in chronic stroke patients, it can indeed help such patients learn new motor skills and achieve more independence in their daily lives.
Despite their different triggers, the same molecular chain of events appears to be responsible for brain cell death from strokes, injuries and even such neurodegenerative diseases as Alzheimer’s. Now, researchers at Johns Hopkins say they have pinpointed the protein at the end of that chain of events, one that delivers the fatal strike by carving up a cell’s DNA. The find, they say, potentially opens up a new avenue for the development of drugs to prevent, stop or weaken the process.
In a collaborative effort with scientists at six Colombian hospitals, Johns Hopkins Medicine researchers report what they believe to be the strongest biological evidence to date linking Zika virus infection and Guillain-Barré syndrome.
Researchers at Johns Hopkins report they have identified a protein that enables a toxic natural aggregate to spread from cell to cell in a mammal’s brain — and a way to block that protein’s action.
Scientists report that a specialized drug screen test using lab-grown human cells has revealed two classes of compounds already in the pharmaceutical arsenal that may work against mosquito-borne Zika virus infections.
Johns Hopkins neuroscientists believe they have figured out how some mammals’ brains — in this case, rats — solve certain navigational problems. If there’s a “reward” at the end of the trip, like the chocolatey drink used in their study, specialized neurons in the hippocampus of the brain “replay” the route taken to get it, but backward. And the greater the reward, the more often the rats’ brains replay it.
Using a novel, newly developed mouse model that mimics the development of Alzheimer’s disease in humans, Johns Hopkins researchers say they have been able to determine that a one-two punch of major biological “insults” must occur in the brain to cause the dementia that is the hallmark of the disease. A description of their experiments is published online in the journal Nature Communications.
Researchers at Johns Hopkins say they have gleaned two important new clues in the fight against Parkinson’s disease: that blocking an enzyme called c-Abl prevents the disease in specially bred mice, and that a chemical tag on a second protein may signal the disorder’s presence and progression.
In a proof-of-principle study, a team of physicians and bioinformatics experts at Johns Hopkins reports they were able to diagnose or rule out suspected brain infections using so called next-generation genetic sequencing of brain tissue samples.
Request an Appointment
Adult Neurology: 410-955-9441
Pediatric Neurology: 410-955-4259
Adult Neurosurgery: 410-955-6406
Pediatric Neurosurgery: 410-955-7337
Already a Patient?
Traveling for Care?
Whether you're crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins.