Skip Navigation
 
 
 
 xxx
 
Print This Page
Share this page: More
 

The Spinal Fusion Laboratory

Addressing a Common Challenge

spinal fusion surgery

Fusion surgery can treat a number of problems with the spine, including those arising from trauma, inborn deformity, degenerative disease, infection and tumors.

But five to 35 percent of these procedures fail, even when using the "gold standard" treatment  of grafting bone from the patient’s own iliac crest.

Fusion failure, otherwise known as pseudoarthrosis, is a major cause of failed back surgery syndrome (FBSS) and results in significant pain and disability, increasing the need for additional procedures and driving up health care costs.

Advancing Techniques, Improving Results

The ultimate goal of the Spinal Fusion Laboratory is to eliminate pseudoarthrosis by using animal models to study various strategies for improving spinal fusion outcomes, including:

  • Delivery of various growth factors and biological agents
  • Stem cell therapies
  • Tissue engineering approaches

Spinal fusion in our animal models is assessed using a combination of complementary techniques, incorporating manual palpitation, X-ray and computed tomography (CT) imaging, histology and biomechanical testing.

Our laboratory is also interested in problems concerning overall spine health. In particular, we aim to investigate therapies for improving vertebral bone quality in patients with conditions such as osteoporosis that may require future spinal fusion procedures.

Currently we are developing an animal model to explore the effects of localized radiation therapy on spinal structure and stability, and testing potential therapies for the prevention of vertebral compression fractures in spinal oncology patients.

Spinal Fusion Team
 

Scheduled for Neurosurgery at Johns Hopkins?

Watch the patient experience video before you come

Related Links

CME Event
Fourth Annual Spine Workshop: September 5-6, 2014

A Framework for Spinal Column Tumor Management
Daniel Sciubba, M.D. helps you understand neurosurgical treatment planning for tumors of the spinal column, along with developing innovations in radiation and chemotherapy.

COLLABORATIONS IN DISCOVERY
A Rare Chance to Cure A Difficult Cancer
Researchers at the Johns Hopkins Neurosurgical Spine Center are developing new surgical techniques to remove chordomas.

More News and Media

Out-of-State and International Patients - Find Out More

 
 
 
 
 

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.

Privacy Policy and Disclaimer