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Neurology and Neurosurgery

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Cerebrospinal Fluid (CSF) Repository

Currently there is no definitive test for Multiple Sclerosis (MS) and it may take several years to establish the diagnosis in some patients. Others may never have a definite diagnosis. It is generally agreed that if we were able to analyze the entire proteome and lipidome of the brain of MS patients, signature patterns could be established that would be diagnostic of the disease.

Since brain tissue is not accessible in live patients, but is bathed by the cerebrospinal fluid (CSF), we established a CSF bank of prospectively collected samples. This is the only such CSF bank in the country.

We have now applied highly sophisticated state-of-the-art instrumentation to analyze these samples with provocative results. Preliminary findings have been presented at national scientific meeting and further analysis is underway. Collaborators include Dr. Carlos Pardo. Dr Norman Haughey, a leading expert on lipidomic techniques, is using this fluid for studies of lipidic profiles and biomarker identification.

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