Skip Navigation
Search Menu
Neurology and Neurosurgery

In This Section      
Print This Page

Symptoms of Neurofibromatosis (NF) Type 1

NF type 1 can affect many parts of the body. Most people with NF1 have some combination of these symptoms by age 10. Be aware that this list is not diagnostic of NF1. Only a physician can diagnose you with neurofibromatosis.

Features and neurological dysfunctions associated with NF1

NF1 can affect the skin, eyes, bones, veins, nerves, and a person's general constitution. The following is a list of some of the common features associated with NF type 1:

Skin:

  • Café au lait spots
  • Dermal neurofibromas
  • Freckling

Eye:

Bone:

Also called osseous lesions, bony malformations commonly found in patients with NF1 include the following:

  • Pseudoarthrosis
  • Tibial bowing
  • Sphenoid wing dysplasia

Vascular (vein):

  • Aneurysm
  • Coarctation of the aorta
  • Hypertension
  • Moyamoya disease
  • Renal artery stenosis
  • Stroke

Nervous system:

About 15% of people with NF1 develop brain tumors called gliomas. Gliomas usually develop in childhood, and the most common gliomas associated with NF1 are the following:

Peripheral nervous system:

Learn more about tumors associated with NF type 1.

Other manifestations of NF1 may include:

  • ADHD / Learning disabilities (occur in 75% of patients with NF1)
  • Macrocephaly (abnormally large head circumference)
  • Headache
  • Hearing loss
  • High blood pressure
  • Numbness and/or weakness
  • Scoliosis
  • Short stature

For more information, contact the Johns Hopkins Comprehensive Neurofibromatosis (NF) Center at 410-502-6732.

Request an Appointment

Maryland Patients

For assistance with making an appointment, please contact the Johns Hopkins Comprehensive Neurofibromatosis Center at 410-502-6732.
Request an Appointment

Adult Neurology: 410-955-9441
Pediatric Neurology: 410-955-4259
Adult Neurosurgery: 410-955-6406
Pediatric Neurosurgery: 410-955-7337

 

Traveling for Care?

Whether you're crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins.

Outside of Maryland (toll free)
410-464-6713

Request an Appointment
Medical Concierge Services

International Patients
+1-410-502-7683

Request an Appointment
Medical Concierge Services

 
blue suitcase