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Dr. Aleksander Popel


Biomedical Engineering



Clinical Interests

Biomedical Engineering

Research Summary

Biomedical Engineering

Journal Citations

Cano Mdel, V.; Karagiannis, E.D.; Soliman, M.; Bakir, B.; Zhuang, W.; Popel, A.S.; Gehlbach, P.L. A peptide derived from type 1 thrombospondin repeat-containing protein WISP-1 inhibits corneal and choroidal neovascularization. Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3840-3845.
Chen, K.; Pittman, R.N.; Popel, A.S. Hemorrhagic shock and nitric oxide release from erythrocytic nitric oxide synthase: a quantitative analysis. Microvasc Res. 2009 Jun;78(1):107-118.
Chen, K.; Popel, A.S. Nitric oxide production pathways in erythrocytes and plasma. Biorheology. 2009;46(2):107-119.
Chung, B.; Kim, S.; Johnson, P.C.; Popel, A.S. Computational fluid dynamics of aggregating red blood cells in postcapillary venules. Comput Methods Biomech Biomed Engin. 2009 Aug;12(4):385-397.
Koskimaki, J.E.; Karagiannis, E.D.; Rosca, E.V.; Vesuna, F.; Winnard, P.T., Jr.; Raman, V.; Bhujwalla, Z.M.; Popel, A.S. Peptides derived from type IV collagen, CXC chemokines, and thrombospondin-1 domain-containing proteins inhibit neovascularization and suppress tumor growth in MDA-MB-231 breast cancer xenografts. Neoplasia. 2009 Dec;11(12):1285-1291.
Qutub, A.A.; Liu, G.; Vempati, P.; Popel, A.S. Integration of angiogenesis modules at multiple scales: from molecular to tissue. Pac Symp Biocomput. 2009:316-327.
Qutub, A.A.; Mac Gabhann, F.; Karagiannis, E.D.; Vempati, P.; Popel, A.S. Multiscale models of angiogenesis. IEEE Eng Med Biol Mag. 2009 Mar-Apr;28(2):14-31.
Qutub, A.A.; Popel, A.S. Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sprouting. BMC Syst Biol. 2009;3:13.
Schumacher, K.R.; Popel, A.S.; Anvari, B.; Brownell, W.E.; Spector, A.A. Computational analysis of the tether-pulling experiment to probe plasma membrane-cytoskeleton interaction in cells. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Oct;80(4 Pt 1):041905.
Stefanini, M.O.; Wu, F.T.; Mac Gabhann, F.; Popel, A.S. The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling. PLoS Comput Biol. 2009 Dec;5(12):e1000622.
Wu, F.T.; Stefanini, M.O.; Gabhann, F.M.; Kontos, C.D.; Annex, B.H.; Popel, A.S. A systems biology perspective on sVEGFR1: its biological function, pathogenic role & therapeutic use. J Cell Mol Med. 2009 Oct 16.
Wu, F.T.; Stefanini, M.O.; Mac Gabhann, F.; Kontos, C.D.; Annex, B.H.; Popel, A.S. Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport. Physiol Genomics. 2009 Jun 10;38(1):29-41.
Wu, F.T.; Stefanini, M.O.; Mac Gabhann, F.; Popel, A.S. Modeling of growth factor-receptor systems from molecular-level protein interaction networks to whole-body compartment models. Methods Enzymol. 2009;467:461-497.
Wu, F.T.; Stefanini, M.O.; Mac Gabhann, F.; Popel, A.S. A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap. PLoS One. 2009;4(4):e5108.
Zhang, J.; Johnson, P.C.; Popel, A.S. Effects of erythrocyte deformability and aggregation on the cell free layer and apparent viscosity of microscopic blood flows. Microvasc Res. 2009 May;77(3):265-272.
Koskimaki, J.E.; Karagiannis, E.D.; Tang, B.C.; Hammers, H.; Watkins, D.N.; Pili, R.; Popel, A.S. Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model. BMC Cancer. 2010;10:29.
Stefanini, M.O.; Wu, F.T.; Mac Gabhann, F.; Popel, A.S. Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model. Cancer Res. 2010 Dec 1;70(23):9886-9894.


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