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Dr. Sushant Kachhap

Ph.D.
Sushant Kachhap
Titles

Assistant Professor in Oncology in the Prostate Cancer/Genitourologic Program

Schools\Degrees

Ph.D., Cancer Research Institute, Mumbai, India

Training

Joined the laboratory of Dr. Michael Carducci as a postdoctoral fellow during which he developed into an independent investigator.

Research Summary

Dr. Kachhap will continue his scholarly activities to explore the role of chromatin remodeling agents in a number of important pathways, those relating to metastasis and DNA repair and radiosensitization.

Journal Citations

Qian, D.Z.; Kachhap, S.K.; Collis, S.J.; Verheul, H.M.; Carducci, M.A.; Atadja, P.; Pili, R. Class II Histone Deacetylases Are Associated with VHL-Independent Regulation of Hypoxia-Inducible Factor 1{alpha}. Cancer Res. 2006 Sep 1;66(17):8814-8821.

Kachhap, S.K.; Faith, D.; Qian, D.Z.; Shabbeer, S.; Galloway, N.L.; Pili, R.; Denmeade, S.R.; DeMarzo, A.M.; Carducci, M.A. The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin. PLoS ONE. 2007;2(9):e844.

Shabbeer, S.; Kortenhorst, M.S.; Kachhap, S.; Galloway, N.; Rodriguez, R.; Carducci, M.A. Multiple Molecular pathways explain the anti-proliferative effect of valproic acid on prostate cancer cells in vitro and in vivo. Prostate. 2007 Jul 1;67(10):1099-1110.

Zhou, S.; Kachhap, S.; Sun, W.; Wu, G.; Chuang, A.; Poeta, L.; Grumbine, L.; Mithani, S.K.; Chatterjee, A.; Koch, W.; Westra, W.H.; Maitra, A.; Glazer, C.; Carducci, M.; Sidransky, D.; McFate, T.; Verma, A.; Califano, J.A. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7540-7545.

Kortenhorst, M.S.; Zahurak, M.; Shabbeer, S.; Kachhap, S.; Galloway, N.; Parmigiani, G.; Verheul, H.M.; Carducci, M.A. A multiple-loop, double-cube microarray design applied to prostate cancer cell lines with variable sensitivity to histone deacetylase inhibitors. Clin Cancer Res. 2008 Nov 1;14(21):6886-6894.

Shabbeer, S.; Sobolewski, M.; Anchoori, R.K.; Kachhap, S.; Davidson, N.; Carducci, M.A.; Khan, S.R. Fenugreek: A naturally occurring edible spice as an anticancer agent. Cancer Biol Ther. 2009 Feb 18;8(3).

Kachhap, S.K.; Rosmus, N.; Collis, S.J.; Kortenhorst, M.S.; Wissing, M.D.; Hedayati, M.; Shabbeer, S.; Mendonca, J.; Deangelis, J.; Marchionni, L.; Lin, J.; Hoti, N.; Nortier, J.W.; DeWeese, T.L.; Hammers, H.; Carducci, M.A. Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor. PLoS One. 2010;5(6):e11208.

Lin, J.; Haffner, M.C.; Zhang, Y.; Lee, B.H.; Brennen, W.N.; Britton, J.; Kachhap, S.K.; Shim, J.S.; Liu, J.O.; Nelson, W.G.; Yegnasubramanian, S.; Carducci, M.A. Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth. Prostate. 2011 Mar 1;71(4):333-343.

 

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