Dr. Paul T. Strickland

Ph.D.

410-955-4456 (p)

410-955-0617 (f)

Titles

Professor of Evironmental Health Sciences,The Johns Hopkins Bloomberg School of Public Health, Joint Appointment in Oncology

Research Summary

The research conducted in my laboratory focuses on molecular biomonitoring of genotoxic agents and genetic polymorphisms associated with their metabolism. The general theme is the assessment of carcinogen metabolites and genetic damage in human populations with known or suspected exposure to various occupational or environmental carcinogens. This approach has widespread application in assessing previous exposure to carcinogens and is increasingly being used as a predictor of ultimate disease risk. The ability to measure carcinogen metabolites and genetic damage in human tissues allows one to address a variety of public health issues related to exposure assessment and individual susceptibility to cancer. Furthermore, elucidating the spectrum of common polymorphisms in carcinogen-metabolizing and other genes associated with disease outcome provides an approach to assessing individual susceptibility to cancer.

Journal Citations

Fagundes, R.B.; Abnet, C.C.; Strickland, P.T.; Kamangar, F.; Roth, M.J.; Taylor, P.R.; Dawsey, S.M. Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking mate in healthy subjects from Rio Grande do Sul, Brazil. BMC Cancer. 2006;6:139.

Genkinger, J.M.; Platz, E.A.; Hoffman, S.C.; Strickland, P.; Huang, H.Y.; Comstock, G.W.; Helzlsouer, K.J. C47T polymorphism in manganese superoxide dismutase (MnSOD), antioxidant intake and survival. Mechanisms of ageing and development. 2006 Apr;127(4):371-377.

Abnet, C.C.; Fagundes, R.B.; Strickland, P.T.; Kamangar, F.; Roth, M.J.; Taylor, P.R.; Dawsey, S.M. The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil. Carcinogenesis. 2007 Jan;28(1):112-117.

Engel, L.S.; Laden, F.; Andersen, A.; Strickland, P.T.; Blair, A.; Needham, L.L.; Barr, D.B.; Wolff, M.S.; Helzlsouer, K.; Hunter, D.J.; Lan, Q.; Cantor, K.P.; Comstock, G.W.; Brock, J.W.; Bush, D.; Hoover, R.N.; Rothman, N. Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin's lymphoma: a report from three cohorts. Cancer Res. 2007 Jun 1;67(11):5545-5552.

Gunter, M.J.; Divi, R.L.; Kulldorff, M.; Vermeulen, R.; Haverkos, K.J.; Kuo, M.M.; Strickland, P.; Poirier, M.C.; Rothman, N.; Sinha, R. Leukocyte polycyclic aromatic hydrocarbon-DNA adduct formation and colorectal adenoma. Carcinogenesis. 2007 Jul;28(7):1426-1429.

Huang, H.Y.; Thuita, L.; Strickland, P.; Hoffman, S.C.; Comstock, G.W.; Helzlsouer, K.J. Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. BMC genetics. 2007;8:7.

Visvanathan, K.; Crum, R.M.; Strickland, P.T.; You, X.; Ruczinski, I.; Berndt, S.I.; Alberg, A.J.; Hoffman, S.C.; Comstock, G.W.; Bell, D.A.; Helzlsouer, K.J. Alcohol dehydrogenase genetic polymorphisms, low-to-moderate alcohol consumption, and risk of breast cancer. Alcoholism, clinical and experimental research. 2007 Mar;31(3):467-476.

Chen, J.; Ruczinski, I.; Jorgensen, T.J.; Yenokyan, G.; Yao, Y.; Alani, R.; Liegeois, N.J.; Hoffman, S.C.; Hoffman-Bolton, J.; Strickland, P.T.; Helzlsouer, K.J.; Alberg, A.J. Nonmelanoma skin cancer and risk for subsequent malignancy. J Natl Cancer Inst. 2008 Sep 3;100(17):1215-1222.

Gallicchio, L.; Chang, H.; Christo, D.K.; Thuita, L.; Huang, H.Y.; Strickland, P.; Ruczinski, I.; Hoffman, S.C.; Helzlsouer, K.J. Single nucleotide polymorphisms in inflammation-related genes and mortality in a community-based cohort in Washington County, Maryland. Am J Epidemiol. 2008 Apr 1;167(7):807-813.

Gallicchio, L.; Kalesan, B.; Huang, H.Y.; Strickland, P.; Hoffman, S.C.; Helzlsouer, K.J. Genetic polymorphisms of peroxisome proliferator-activated receptors and the risk of cardiovascular morbidity and mortality in a community-based cohort in washington county, Maryland. PPAR research. 2008;2008:276581.

Marlow, R.; Strickland, P.; Lee, J.S.; Wu, X.; Pebenito, M.; Binnewies, M.; Le, E.K.; Moran, A.; Macias, H.; Cardiff, R.D.; Sukumar, S.; Hinck, L. SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. Cancer Res. 2008 Oct 1;68(19):7819-7827.

Strickland, P.T.; Kensler, T.W. Environmental Factors. In: Abeloff, M.D.; Armitage, J.O.; Niederhuber, J.E.; Kastan, M.B.; McKenna, G., editors, Clinical Oncology. Philadelphia: Elsevier; 2008.

Chae, Y.K.; Huang, H.Y.; Strickland, P.; Hoffman, S.C.; Helzlsouer, K. Genetic polymorphisms of estrogen receptors alpha and beta and the risk of developing prostate cancer. PLoS One. 2009;4(8):e6523.

Gallicchio, L.; Chang, H.H.; Christo, D.K.; Thuita, L.; Huang, H.Y.; Strickland, P.; Ruczinski, I.; Clipp, S.; Helzlsouer, K.J. Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study. BMC medical genetics. 2009;10:103.

Lam, T.K.; Ruczinski, I.; Helzlsouer, K.; Shugart, Y.Y.; Li, K.E.; Clipp, S.; Strickland, P.T.; Alberg, A.J. Copy number variants of GSTM1 and GSTT1 in relation to lung cancer risk in a prospective cohort study. Annals of epidemiology. 2009 Aug;19(8):546-552.

Lee, K.H.; Vermeulen, R.; Lenters, V.; Cho, S.H.; Strickland, P.T.; Kang, D. Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children. International archives of occupational and environmental health. 2009 Aug;82(8):961-968.

Suwan-ampai, P.; Navas-Acien, A.; Strickland, P.T.; Agnew, J. Involuntary tobacco smoke exposure and urinary levels of polycyclic aromatic hydrocarbons in the United States, 1999 to 2002. Cancer Epidemiol Biomarkers Prev. 2009 Mar;18(3):884-893.

Wheless, L.; Ruczinski, I.; Alani, R.M.; Clipp, S.; Hoffman-Bolton, J.; Jorgensen, T.J.; Liegeois, N.J.; Strickland, P.T.; Alberg, A.J. The association between skin characteristics and skin cancer prevention behaviors. Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2613-2619.