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Dr. Thomas Kensler

Ph.D.
Thomas Kensler
Interests

Chemoprevention

Journal Citations

Agoston, E.S.; Hatcher, M.A.; Kensler, T.W.; Posner, G.H. Vitamin D analogs as anti-carcinogenic agents. Anticancer Agents Med Chem. 2006 Jan;6(1):53-71.

Egner, P.A.; Groopman, J.D.; Wang, J.S.; Kensler, T.W.; Friesen, M.D. Quantification of aflatoxin-B1-N7-Guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry. Chemical research in toxicology. 2006 Sep;19(9):1191-1195.

Glintborg, B.; Weimann, A.; Kensler, T.W.; Poulsen, H.E. Oltipraz chemoprevention trial in Qidong, People's Republic of China: unaltered oxidative biomarkers. Free Radic Biol Med. 2006 Sep 15;41(6):1010-1014.

Gong, J.; Neels, J.F.; Yu, X.; Kensler, T.W.; Peterson, L.A.; Sturla, S.J. Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity. J Med Chem. 2006 Apr 20;49(8):2593-2599.

Huang, Y.; Yan, J.; Lubet, R.; Kensler, T.W.; Sutter, T.R. Identification of novel transcriptional networks in response to treatment with the anticarcinogen 3H-1,2-dithiole-3-thione. Physiol Genomics. 2006 Jan 12;24(2):144-153.

Kwak, M.K.; Kensler, T.W. Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathway. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1350-1357.

Okawa, H.; Motohashi, H.; Kobayashi, A.; Aburatani, H.; Kensler, T.W.; Yamamoto, M. Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun. 2006 Jan 6;339(1):79-88.

Osburn, W.O.; Wakabayashi, N.; Misra, V.; Nilles, T.; Biswal, S.; Trush, M.A.; Kensler, T.W. Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Arch Biochem Biophys. 2006 Oct 1;454(1):7-15.

Peleg, S.; Petersen, K.S.; Suh, B.C.; Dolan, P.; Agoston, E.S.; Kensler, T.W.; Posner, G.H. Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation. J Med Chem. 2006 Dec 14;49(25):7513-7517.

Scholl, P.F.; McCoy, L.; Kensler, T.W.; Groopman, J.D. Quantitative analysis and chronic dosimetry of the aflatoxin B1 plasma albumin adduct Lys-AFB1 in rats by isotope dilution mass spectrometry. Chemical research in toxicology. 2006 Jan;19(1):44-49.

Singh, A.; Rangasamy, T.; Thimmulappa, R.K.; Lee, H.; Osburn, W.O.; Brigelius-Flohe, R.; Kensler, T.W.; Yamamoto, M.; Biswal, S. Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. Am J Respir Cell Mol Biol. 2006 Dec;35(6):639-650.

Sinishtaj, S.; Jeon, H.B.; Dolan, P.; Kensler, T.W.; Posner, G.H. Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1alpha,25-dihydroxyvitamin D3. Bioorganic & medicinal chemistry. 2006 Sep 15;14(18):6341-6348.

Skipper, P.L.; Trudel, L.J.; Kensler, T.W.; Groopman, J.D.; Egner, P.A.; Liberman, R.G.; Wogan, G.N.; Tannenbaum, S.R. DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice. Chemical research in toxicology. 2006 Aug;19(8):1086-1090.

Thimmulappa, R.K.; Scollick, C.; Traore, K.; Yates, M.; Trush, M.A.; Liby, K.T.; Sporn, M.B.; Yamamoto, M.; Kensler, T.W.; Biswal, S. Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun. 2006 Dec 29;351(4):883-889.

Yates, M.S.; Kwak, M.K.; Egner, P.A.; Groopman, J.D.; Bodreddigari, S.; Sutter, T.R.; Baumgartner, K.J.; Roebuck, B.D.; Liby, K.T.; Yore, M.M.; Honda, T.; Gribble, G.W.; Sporn, M.B.; Kensler, T.W. Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Cancer Res. 2006 Feb 15;66(4):2488-2494.

Yu, X.; Egner, P.A.; Wakabayashi, J.; Wakabayashi, N.; Yamamoto, M.; Kensler, T.W. Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase. J Biol Chem. 2006 Sep 8;281(36):26245-26252.

Chen, J.G.; Kuang, S.Y.; Egner, P.A.; Lu, J.H.; Zhu, Y.R.; Wang, J.B.; Zhang, B.C.; Chen, T.Y.; Munoz, A.; Kensler, T.W.; Groopman, J.D. Acceleration to death from liver cancer in people with hepatitis B viral mutations detected in plasma by mass spectrometry. Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1213-1218.

Cornblatt, B.S.; Ye, L.; Dinkova-Kostova, A.T.; Erb, M.; Fahey, J.W.; Singh, N.K.; Chen, M.S.; Stierer, T.; Garrett-Mayer, E.; Argani, P.; Davidson, N.E.; Talalay, P.; Kensler, T.W.; Visvanathan, K. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis. 2007 Jul;28(7):1485-1490.

Fahey, J.W.; Kensler, T.W. Role of dietary supplements/nutraceuticals in chemoprevention through induction of cytoprotective enzymes. Chemical research in toxicology. 2007 Apr;20(4):572-576.
Gong, J.; Vaidyanathan, V.G.;
Yu, X.; Kensler, T.W.; Peterson, L.A.; Sturla, S.J. Depurinating acylfulvene-DNA adducts: characterizing cellular chemical reactions of a selective antitumor agent. J Am Chem Soc. 2007 Feb 21;129(7):2101-2111.

Kensler, T.W.; Wakabayashi, N.; Biswal, S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annual review of pharmacology and toxicology. 2007;47:89-116.

Kwak, M.K.; Cho, J.M.; Huang, B.; Shin, S.; Kensler, T.W. Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells. Free Radic Biol Med. 2007 Sep 1;43(5):809-817.

Kwak, M.K.; Huang, B.; Chang, H.; Kim, J.A.; Kensler, T.W. Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein. Life sciences. 2007 Jun 6;80(26):2411-2420.

Manandhar, S.; Cho, J.M.; Kim, J.A.; Kensler, T.W.; Kwak, M.K. Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. Eur J Pharmacol. 2007 Dec 22;577(1-3):17-27.

Mas, S.; Crescenti, A.; Gasso, P.; Deulofeu, R.; Molina, R.; Ballesta, A.; Kensler, T.W.; Lafuente, A. Induction of apoptosis in HT-29 cells by extracts from isothiocyanates-rich varieties of Brassica oleracea. Nutr Cancer. 2007;58(1):107-114.

Osburn, W.O.; Karim, B.; Dolan, P.M.; Liu, G.; Yamamoto, M.; Huso, D.L.; Kensler, T.W. Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. Int J Cancer. 2007 Nov 1;121(9):1883-1891.

Papaiahgari, S.; Yerrapureddy, A.; Reddy, S.R.; Reddy, N.M.; Dodd, O.J.; Crow, M.T.; Grigoryev, D.N.; Barnes, K.; Tuder, R.M.; Yamamoto, M.; Kensler, T.W.; Biswal, S.; Mitzner, W.; Hassoun, P.M.; Reddy, S.P. Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. Am J Respir Crit Care Med. 2007 Dec 15;176(12):1222-1235.

Petersen, K.S.; Dolan, P.M.; Kensler, T.W.; Peleg, S.; Posner, G.H. Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1 alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation. J Med Chem. 2007 Nov 15;50(23):5824-5832.

Posner, G.H.; Suh, B.C.; Petersen, K.S.; Dolan, P.; Agoston, E.S.; Kensler, T.W.; Koh, J.T.; Peleg, S. Difluoromethyl analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation. The Journal of steroid biochemistry and molecular biology. 2007 Mar;103(3-5):213-221.

Pratt, M.M.; Reddy, A.P.; Hendricks, J.D.; Pereira, C.; Kensler, T.W.; Bailey, G.S. The importance of carcinogen dose in chemoprevention studies: quantitative interrelationships between, dibenzo[a,l]pyrene dose, chlorophyllin dose, target organ DNA adduct biomarkers and final tumor outcome. Carcinogenesis. 2007 Mar;28(3):611-624.

Reddy, N.M.; Kleeberger, S.R.; Cho, H.Y.; Yamamoto, M.; Kensler, T.W.; Biswal, S.; Reddy, S.P. Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. Am J Respir Cell Mol Biol. 2007 Jul;37(1):3-8.

Reddy, N.M.; Kleeberger, S.R.; Yamamoto, M.; Kensler, T.W.; Scollick, C.; Biswal, S.; Reddy, S.P. Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection. Physiol Genomics. 2007 Dec 19;32(1):74-81.

Shah, Z.A.; Li, R.C.; Thimmulappa, R.K.; Kensler, T.W.; Yamamoto, M.; Biswal, S.; Dore, S. Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury. Neuroscience. 2007 Jun 15;147(1):53-59.

Shin, S.; Wakabayashi, N.; Misra, V.; Biswal, S.; Lee, G.H.; Agoston, E.S.; Yamamoto, M.; Kensler, T.W. NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Mol Cell Biol. 2007 Oct;27(20):7188-7197.

Simonich, M.T.; Egner, P.A.; Roebuck, B.D.; Orner, G.A.; Jubert, C.; Pereira, C.; Groopman, J.D.; Kensler, T.W.; Dashwood, R.H.; Williams, D.E.; Bailey, G.S. Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis. 2007 Jun;28(6):1294-1302.

Thimmulappa, R.K.; Fuchs, R.J.; Malhotra, D.; Scollick, C.; Traore, K.; Bream, J.H.; Trush, M.A.; Liby, K.T.; Sporn, M.B.; Kensler, T.W.; Biswal, S. Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxid Redox Signal. 2007 Nov;9(11):1963-1970.

Usera, A.R.; Dolan, P.M.; Kensler, T.W.; Posner, G.H. Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1alpha,25-dihydroxyvitamin D3: chemical synthesis and biological evaluation. Bioorganic & medicinal chemistry. 2007 Aug 15;15(16):5509-5518.

Wang, J.; Fields, J.; Zhao, C.; Langer, J.; Thimmulappa, R.K.; Kensler, T.W.; Yamamoto, M.; Biswal, S.; Dore, S. Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radic Biol Med. 2007 Aug 1;43(3):408-414.

Yates, M.S.; Kensler, T.W. Chemopreventive promise of targeting the Nrf2 pathway. Drug news & perspectives. 2007 Mar;20(2):109-117.

Yates, M.S.; Kensler, T.W. Keap1 eye on the target: chemoprevention of liver cancer. Acta pharmacologica Sinica. 2007 Sep;28(9):1331-1342.

Yates, M.S.; Tauchi, M.; Katsuoka, F.; Flanders, K.C.; Liby, K.T.; Honda, T.; Gribble, G.W.; Johnson, D.A.; Johnson, J.A.; Burton, N.C.; Guilarte, T.R.; Yamamoto, M.; Sporn, M.B.; Kensler, T.W. Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol Cancer Ther. 2007 Jan;6(1):154-162.

Bodreddigari, S.; Jones, L.K.; Egner, P.A.; Groopman, J.D.; Sutter, C.H.; Roebuck, B.D.; Guengerich, F.P.; Kensler, T.W.; Sutter, T.R. Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. Chemical research in toxicology. 2008 May;21(5):1134-1142.

Bransfield, L.A.; Rennie, A.; Visvanathan, K.; Odwin, S.A.; Kensler, T.W.; Yager, J.D.; Friesen, M.D.; Groopman, J.D. Formation of two novel estrogen guanine adducts and HPLC/MS detection of 4-hydroxyestradiol-N7-guanine in human urine. Chemical research in toxicology. 2008 Aug;21(8):1622-1630.

Colburn, N.H.; Kensler, T.W. Targeting transcription factors for cancer prevention--the case of Nrf2. Cancer prevention research (Philadelphia, Pa. 2008 Aug;1(3):153-155.

Egner, P.A.; Kensler, T.W.; Chen, J.G.; Gange, S.J.; Groopman, J.D.; Friesen, M.D. Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry. Chemical research in toxicology. 2008 Oct;21(10):1991-1996.

Groopman, J.D.; Kensler, T.W. Aflatoxin and Hepatitis B Virus: A Conspiracy in Human Liver Cancer. In: Wild, C.P.; Vineis, P.; Garte, S., editors, Molecular Epidemiology of Chronic Diseases: Wiley; 2008. p. 323-342.

Groopman, J.D.; Kensler, T.W.; Wild, C.P. Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries. Annual review of public health. 2008;29:187-203.

Johnson, D.N.; Egner, P.A.; Obrian, G.; Glassbrook, N.; Roebuck, B.D.; Sutter, T.R.; Payne, G.A.; Kensler, T.W.; Groopman, J.D. Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry. Chemical research in toxicology. 2008 Mar;21(3):752-760.

Liby, K.; Yore, M.M.; Roebuck, B.D.; Baumgartner, K.J.; Honda, T.; Sundararajan, C.; Yoshizawa, H.; Gribble, G.W.; Williams, C.R.; Risingsong, R.; Royce, D.B.; Dinkova-Kostova, A.T.; Stephenson, K.K.; Egner, P.A.; Yates, M.S.; Groopman, J.D.; Kensler, T.W.; Sporn, M.B. A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin. Cancer Res. 2008 Aug 15;68(16):6727-6733.

Osburn, W.O.; Kensler, T.W. Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutation research. 2008 Jul-Aug;659(1-2):31-39.

Osburn, W.O.; Yates, M.S.; Dolan, P.D.; Chen, S.; Liby, K.T.; Sporn, M.B.; Taguchi, K.; Yamamoto, M.; Kensler, T.W. Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. Toxicol Sci. 2008 Jul;104(1):218-227.

Pearson, K.J.; Lewis, K.N.; Price, N.L.; Chang, J.W.; Perez, E.; Cascajo, M.V.; Tamashiro, K.L.; Poosala, S.; Csiszar, A.; Ungvari, Z.; Kensler, T.W.; Yamamoto, M.; Egan, J.M.; Longo, D.L.; Ingram, D.K.; Navas, P.; de Cabo, R. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2325-2330.

Reddy, N.M.; Kleeberger, S.R.; Bream, J.H.; Fallon, P.G.; Kensler, T.W.; Yamamoto, M.; Reddy, S.P. Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling. Oncogene. 2008 Oct 2;27(44):5821-5832.

Strickland, P.T.; Kensler, T.W. Environmental Factors. In: Abeloff, M.D.; Armitage, J.O.; Niederhuber, J.E.; Kastan, M.B.; McKenna, G., editors, Clinical Oncology. Philadelphia: Elsevier; 2008.

Williams, M.A.; Rangasamy, T.; Bauer, S.M.; Killedar, S.; Karp, M.; Kensler, T.W.; Yamamoto, M.; Breysse, P.; Biswal, S.; Georas, S.N. Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter. J Immunol. 2008 Oct 1;181(7):4545-4559.

An, S.S.; Kim, J.; Ahn, K.; Trepat, X.; Drake, K.J.; Kumar, S.; Ling, G.; Purington, C.; Rangasamy, T.; Kensler, T.W.; Mitzner, W.; Fredberg, J.J.; Biswal, S. Cell stiffness, contractile stress and the role of extracellular matrix. Biochem Biophys Res Commun. 2009 May 15;382(4):697-703.

Blackford, A.; Parmigiani, G.; Kensler, T.W.; Wolfgang, C.; Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Eshleman, J.R.; Goggins, M.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Klein, A.; Cameron, J.L.; Olino, K.; Schulick, R.; Winter, J.; Vogelstein, B.; Velculescu, V.E.; Kinzler, K.W.; Hruban, R.H. Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res. 2009 Apr 15;69(8):3681-3688.

Holland, R.; Navamal, M.; Velayutham, M.; Zweier, J.L.; Kensler, T.W.; Fishbein, J.C. Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones. Chemical research in toxicology. 2009 Aug;22(8):1427-1434.

Kensler, T.W.; Groopman, J.D. Is it time to advance the chemoprevention of environmental carcinogenesis with microdosing trials? Cancer prevention research (Philadelphia, Pa. 2009 Dec;2(12):1003-1007.

Kensler, T.W.; Wakabayashi, N. Nrf2: Friend or Foe for Chemoprevention? Carcinogenesis. 2009 Sep 30.

Kwak, M.K.; Kensler, T.W. Targeting NRF2 signaling for cancer chemoprevention. Toxicol Appl Pharmacol. 2009 Sep 2.
Nagai, N.; Thimmulappa, R.K.; Cano, M.; Fujihara, M.; Izumi-Nagai, K.; Kong, X.; Sporn, M.B.; Kensler, T.W.; Biswal, S.; Handa, J.T. Nrf2 is a critical modulator of the innate immune response in a model of uveitis. Free Radic Biol Med. 2009 Aug 1;47(3):300-306.

Reddy, N.M.; Kleeberger, S.R.; Kensler, T.W.; Yamamoto, M.; Hassoun, P.M.; Reddy, S.P. Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice. J Immunol. 2009 Jun 1;182(11):7264-7271.

Reddy, N.M.; Suryanaraya, V.; Yates, M.S.; Kleeberger, S.R.; Hassoun, P.M.; Yamamoto, M.; Liby, K.T.; Sporn, M.B.; Kensler, T.W.; Reddy, S.P. The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice. Am J Respir Crit Care Med. 2009 Nov 1;180(9):867-874.

Reddy, N.M.; Suryanarayana, V.; Kalvakolanu, D.V.; Yamamoto, M.; Kensler, T.W.; Hassoun, P.M.; Kleeberger, S.R.; Reddy, S.P. Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice. J Immunol. 2009 Oct 1;183(7):4601-4608.

Roebuck, B.D.; Johnson, D.N.; Sutter, C.H.; Egner, P.A.; Scholl, P.F.; Friesen, M.D.; Baumgartner, K.J.; Ware, N.M.; Bodreddigari, S.; Groopman, J.D.; Kensler, T.W.; Sutter, T.R. Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat. Toxicol Sci. 2009 Jan 23.

Shin, S.; Wakabayashi, J.; Yates, M.S.; Wakabayashi, N.; Dolan, P.M.; Aja, S.; Liby, K.T.; Sporn, M.B.; Yamamoto, M.; Kensler, T.W. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. Eur J Pharmacol. 2009 Oct 12;620(1-3):138-144.

Singh, A.; Ling, G.; Suhasini, A.N.; Zhang, P.; Yamamoto, M.; Navas-Acien, A.; Cosgrove, G.; Tuder, R.M.; Kensler, T.W.; Watson, W.H.; Biswal, S. Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radic Biol Med. 2009 Feb 1;46(3):376-386.

Sussan, T.E.; Rangasamy, T.; Blake, D.J.; Malhotra, D.; El-Haddad, H.; Bedja, D.; Yates, M.S.; Kombairaju, P.; Yamamoto, M.; Liby, K.T.; Sporn, M.B.; Gabrielson, K.L.; Champion, H.C.; Tuder, R.M.; Kensler, T.W.; Biswal, S. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):250-255.

Tran, Q.T.; Xu, L.; Phan, V.; Goodwin, S.B.; Rahman, M.; Jin, V.X.; Sutter, C.H.; Roebuck, B.D.; Kensler, T.W.; George, E.O.; Sutter, T.R. Chemical genomics of cancer chemopreventive dithiolethiones. Carcinogenesis. 2009 Mar;30(3):480-486.

Usera, A.R.; Dolan, P.; Kensler, T.W.; Posner, G.H. 'Novel alkyl side chain sulfone 1alpha,25-dihydroxyvitamin D3 analogs: a comparison of in vitro antiproliferative activities and in vivo calcemic activities'. Bioorganic & medicinal chemistry. 2009 Aug 1;17(15):5627-5631.

Wakabayashi, J.; Zhang, Z.; Wakabayashi, N.; Tamura, Y.; Fukaya, M.; Kensler, T.W.; Iijima, M.; Sesaki, H. The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol. 2009 Sep 21;186(6):805-816.

Yates, M.S.; Tran, Q.T.; Dolan, P.M.; Osburn, W.O.; Shin, S.; McCulloch, C.C.; Silkworth, J.B.; Taguchi, K.; Yamamoto, M.; Williams, C.R.; Liby, K.T.; Sporn, M.B.; Sutter, T.R.; Kensler, T.W. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis. 2009 Jun;30(6):1024-1031.

Gruber, F.; Mayer, H.; Lengauer, B.; Mlitz, V.; Sanders, J.M.; Kadl, A.; Bilban, M.; de Martin, R.; Wagner, O.; Kensler, T.W.; Yamamoto, M.; Leitinger, N.; Tschachler, E. NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells. FASEB J. 2010 Jan;24(1):39-48.

Kadl, A.; Meher, A.K.; Sharma, P.R.; Lee, M.Y.; Doran, A.C.; Johnstone, S.R.; Elliott, M.R.; Gruber, F.; Han, J.; Chen, W.; Kensler, T.; Ravichandran, K.S.; Isakson, B.E.; Wamhoff, B.R.; Leitinger, N. Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circ Res. 2010 Sep 17;107(6):737-746.

Kensler, T.W.; Wakabayashi, N. Nrf2: friend or foe for chemoprevention? Carcinogenesis. 2010 Jan;31(1):90-99.

Kwak, M.K.; Kensler, T.W. Targeting NRF2 signaling for cancer chemoprevention. Toxicol Appl Pharmacol. 2010 Apr 1;244(1):66-76.

Malhotra, D.; Portales-Casamar, E.; Singh, A.; Srivastava, S.; Arenillas, D.; Happel, C.; Shyr, C.; Wakabayashi, N.; Kensler, T.W.; Wasserman, W.W.; Biswal, S. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Res. 2010 Sep 1;38(17):5718-5734.

Shah, Z.A.; Li, R.C.; Ahmad, A.S.; Kensler, T.W.; Yamamoto, M.; Biswal, S.; Dore, S. The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway. J Cereb Blood Flow Metab. 2010 Dec;30(12):1951-1961.

Shin, D.H.; Park, H.M.; Jung, K.A.; Choi, H.G.; Kim, J.A.; Kim, D.D.; Kim, S.G.; Kang, K.W.; Ku, S.K.; Kensler, T.W.; Kwak, M.K. The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis. Free Radic Biol Med. 2010 Apr 15;48(8):1051-1063.

Wakabayashi, N.; Shin, S.; Slocum, S.L.; Agoston, E.S.; Wakabayashi, J.; Kwak, M.K.; Misra, V.; Biswal, S.; Yamamoto, M.; Kensler, T.W. Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Sci Signal. 2010;3(130):ra52.

Wakabayashi, N.; Slocum, S.L.; Skoko, J.J.; Shin, S.; Kensler, T.W. When NRF2 talks, who's listening? Antioxid Redox Signal. 2010 Dec 1;13(11):1649-1663.

Zhou, Q.; Chaerkady, R.; Shaw, P.G.; Kensler, T.W.; Pandey, A.; Davidson, N.E. Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells. Proteomics. 2010 Mar;10(5):1029-1039.

 

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