//
Skip Navigation
 
 
 
 
 
Print This Page
Share this page: More
 

Dr. David Sidransky

M.D.
(410) 614-1411 (f)
Interests

Molecular Cancer Detection and Staging

Titles

Professor of Otolaryngology - Head and Neck Surgery
Professor of Oncology
Professor of Pathology
Professor of Cellular & Molecular Medicine
Professor of Urology
Director, Head and Neck Cancer Research
Principal Investigator, Johns Hopkins Head and Neck Cancer SPORE

Schools\Degrees

M.D., Baylor College of Medicine

Training

Intern in Internal Medicine Clinical Investigator Program Univer Dr. Thomas Caskey
Chief Resident in Internal Medicine, Baylor College of Medicine, Houston, TX
Senior Clinical Fellow in Oncology Research Fellow in Oncology, Univer Dr. Bert Vogelstein, The Johns Hopkins University School of Medicine, Baltimore, MD

Certifications

Internal Medicine Oncology Head and Neck Surgery

Clinical Interests

Head and Neck Cancer
Lung Cancer

Research Summary

In this laboratory, we elucidate the molecular genetic changes that drive the progression of various types of cancer. We concentrate on identifying new genetic changes in smoking-associated tumors including lung cancer, head and neck cancer, and bladder cancer. We also investigate the molecular epidemiology of smoking-induced cancers and the link between tobacco smoke and mutations of critical oncogenes. Two recent discoveries are now driving our basic research—p63, a p53 family member, is commonly amplified in SCC and drives cancer progression. We know that WT p53 binds to p63 and degrades p63. Moreover, p63 binds to B56/PP2A, resulting in upregulation of b-catenin and downstream signaling. We also recently discovered BRAF mutations in 70 percent of thyroid tumors. We are identifying downstream signaling mechanisms for BRAF and are working with new BRAF inhibitors for targeted molecular therapy.

Our laboratory is best known for our efforts in molecular-detection approaches based on the identification of clonal genetic changes in many bodily fluids, including urine, saliva, stool and blood. Several major recent innovations in this area have been pioneered by our laboratory. Many of these approaches, such as the hypermethylation of p16 in human cancers and the discovery of mitochondrial mutations at high frequency in many tumor types have shed new light in the field of cancer biology and detection. We also discovered that circulating free DNA was in fact derived from tumor cells by showing that this DNA shared the identical genetic changes present in the primary tumor. This approach may one day lead to a simple blood test to detect cancers at an early stage. Our team also has led new approaches in molecular staging based on the identification of micrometastatic disease in various tumors. This approach may one day be the standard for staging patients with cancer and will allow for more aggressive therapy in patients with minimal residual disease. No matter what area we research, we always try to bridge basic research into the clinical setting.

Journal Citations

Chatterjee, A.; Mambo, E.; Osada, M.; Upadhyay, S.; Sidransky, D. The effect of p53-RNAi and p53 knockout on human 8-oxoguanine DNA glycosylase (hOgg1) activity. Faseb J. 2006 Jan;20(1):112-114.
Chatterjee, A.; Mambo, E.; Sidransky, D. Mitochondrial DNA mutations in human cancer. Oncogene. 2006 Aug 7;25(34):4663-4674.
Chatterjee, A.; Mambo, E.; Zhang, Y.; Deweese, T.; Sidransky, D. Targeting of mutant hogg1 in mammalian mitochondria and nucleus: effect on cellular survival upon oxidative stress. BMC Cancer. 2006;6:235.
Hoque, M.O.; Begum, S.; Topaloglu, O.; Chatterjee, A.; Rosenbaum, E.; Van Criekinge, W.; Westra, W.H.; Schoenberg, M.; Zahurak, M.; Goodman, S.N.; Sidransky, D. Quantitation of promoter methylation of multiple genes in urine DNA and bladder cancer detection. J Natl Cancer Inst. 2006 Jul 19;98(14):996-1004.
Hoque, M.O.; Feng, Q.; Toure, P.; Dem, A.; Critchlow, C.W.; Hawes, S.E.; Wood, T.; Jeronimo, C.; Rosenbaum, E.; Stern, J.; Yu, M.; Trink, B.; Kiviat, N.B.; Sidransky, D. Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer. J Clin Oncol. 2006 Sep 10;24(26):4262-4269.
Hoque, M.O.; Soria, J.C.; Woo, J.; Lee, T.; Lee, J.; Jang, S.J.; Upadhyay, S.; Trink, B.; Monitto, C.; Desmaze, C.; Mao, L.; Sidransky, D.; Moon, C. Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth. Am J Pathol. 2006 Apr;168(4):1345-1353.
Hu, S.; Ewertz, M.; Tufano, R.P.; Brait, M.; Carvalho, A.L.; Liu, D.; Tufaro, A.P.; Basaria, S.; Cooper, D.S.; Sidransky, D.; Ladenson, P.W.; Xing, M. Detection of serum deoxyribonucleic acid methylation markers: a novel diagnostic tool for thyroid cancer. J Clin Endocrinol Metab. 2006 Jan;91(1):98-104.
Jiang, W.W.; Rosenbaum, E.; Mambo, E.; Zahurak, M.; Masayesva, B.; Carvalho, A.L.; Zhou, S.; Westra, W.H.; Alberg, A.J.; Sidransky, D.; Koch, W.; Califano, J.A. Decreased mitochondrial DNA content in posttreatment salivary rinses from head and neck cancer patients. Clin Cancer Res. 2006 Mar 1;12(5):1564-1569.
Jiang, W.W.; Zahurak, M.; Goldenberg, D.; Milman, Y.; Park, H.L.; Westra, W.H.; Koch, W.; Sidransky, D.; Califano, J. Increased plasma DNA integrity index in head and neck cancer patients. Int J Cancer. 2006 Dec 1;119(11):2673-2676.
Kang, S.; Lee, J.M.; Jeon, E.S.; Lee, S.; Kim, H.; Kim, H.S.; Seo, S.S.; Park, S.Y.; Sidransky, D.; Dong, S.M. RASSF1A hypermethylation and its inverse correlation with BRAF and/or KRAS mutations in MSI-associated endometrial carcinoma. Int J Cancer. 2006 Sep 15;119(6):1316-1321.
Kim, M.M.; Glazer, C.A.; Mambo, E.; Chatterjee, A.; Zhao, M.; Sidransky, D.; Califano, J.A. Head and neck cancer cell lines exhibit differential mitochondrial repair deficiency in response to 4NQO. Oral Oncol. 2006 Feb;42(2):201-207.
Kim, M.S.; Yamashita, K.; Baek, J.H.; Park, H.L.; Carvalho, A.L.; Osada, M.; Hoque, M.O.; Upadhyay, S.; Mori, M.; Moon, C.; Sidransky, D. N-methyl-D-aspartate receptor type 2B is epigenetically inactivated and exhibits tumor-suppressive activity in human esophageal cancer. Cancer Res. 2006 Apr 1;66(7):3409-3418.
Masayesva, B.G.; Mambo, E.; Taylor, R.J.; Goloubeva, O.G.; Zhou, S.; Cohen, Y.; Minhas, K.; Koch, W.; Sciubba, J.; Alberg, A.J.; Sidransky, D.; Califano, J. Mitochondrial DNA content increase in response to cigarette smoking. Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):19-24.
Osada, M.; Park, H.L.; Nagakawa, Y.; Begum, S.; Yamashita, K.; Wu, G.; Kim, M.S.; Trink, B.; Sidransky, D. A novel response element confers p63- and p73-specific activation of the WNT4 promoter. Biochem Biophys Res Commun. 2006 Jan 27;339(4):1120-1128.
Ratovitski, E.; Trink, B.; Sidransky, D. p63 and p73: teammates or adversaries? Cancer Cell. 2006 Jan;9(1):1-2.
Singh, A.; Misra, V.; Thimmulappa, R.K.; Lee, H.; Ames, S.; Hoque, M.O.; Herman, J.G.; Baylin, S.B.; Sidransky, D.; Gabrielson, E.; Brock, M.V.; Biswal, S. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med. 2006 Oct;3(10):e420.
Sommer, M.; Poliak, N.; Upadhyay, S.; Ratovitski, E.; Nelkin, B.D.; Donehower, L.A.; Sidransky, D. DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse. Cell Cycle. 2006 Sep;5(17):2005-2011.
Sui, G.; Zhou, S.; Wang, J.; Canto, M.; Lee, E.E.; Eshleman, J.R.; Montgomery, E.A.; Sidransky, D.; Califano, J.A.; Maitra, A. Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: a biomarker for the early detection of cancer. Mol Cancer. 2006;5:73.
Upadhyay, S.; Liu, C.; Chatterjee, A.; Hoque, M.O.; Kim, M.S.; Engles, J.; Westra, W.; Trink, B.; Ratovitski, E.; Sidransky, D. LKB1/STK11 Suppresses Cyclooxygenase-2 Induction and Cellular Invasion through PEA3 in Lung Cancer. Cancer Res. 2006 Aug 15;66(16):7870-7879.
Westra, W.H.; Sidransky, D. Fluorescence visualization in oral neoplasia: shedding light on an old problem. Clin Cancer Res. 2006 Nov 15;12(22):6594-6597.
Wisman, G.B.; Nijhuis, E.R.; Hoque, M.O.; Reesink-Peters, N.; Koning, A.J.; Volders, H.H.; Buikema, H.J.; Boezen, H.M.; Hollema, H.; Schuuring, E.; Sidransky, D.; van der Zee, A.G. Assessment of gene promoter hypermethylation for detection of cervical neoplasia. Int J Cancer. 2006 Oct 15;119(8):1908-1914.
Wu, G.; Guo, Z.; Chatterjee, A.; Huang, X.; Rubin, E.; Wu, F.; Mambo, E.; Chang, X.; Osada, M.; Sook Kim, M.; Moon, C.; Califano, J.A.; Ratovitski, E.A.; Gollin, S.M.; Sukumar, S.; Sidransky, D.; Trink, B. Overexpression of glycosylphosphatidylinositol (GPI) transamidase subunits phosphatidylinositol glycan class T and/or GPI anchor attachment 1 induces tumorigenesis and contributes to invasion in human breast cancer. Cancer Res. 2006 Oct 15;66(20):9829-9836.
Yamashita, K.; Park, H.L.; Kim, M.S.; Osada, M.; Tokumaru, Y.; Inoue, H.; Mori, M.; Sidransky, D. PGP9.5 methylation in diffuse-type gastric cancer. Cancer Res. 2006 Apr 1;66(7):3921-3927.
Zhou, S.; Kassauei, K.; Cutler, D.J.; Kennedy, G.C.; Sidransky, D.; Maitra, A.; Califano, J. An oligonucleotide microarray for high-throughput sequencing of the mitochondrial genome. J Mol Diagn. 2006 Sep;8(4):476-482.
Ball, D.W.; Jin, N.; Rosen, D.M.; Dackiw, A.; Sidransky, D.; Xing, M.; Nelkin, B.D. Selective Growth Inhibition in BRAF Mutant Thyroid Cancer by the Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor AZD6244. J Clin Endocrinol Metab. 2007 Dec;92(12):4712-4718.
Couch, M.E.; Ferris, R.L.; Brennan, J.A.; Koch, W.M.; Jaffee, E.M.; Leibowitz, M.S.; Nepom, G.T.; Erlich, H.A.; Sidransky, D. Alteration of cellular and humoral immunity by mutant p53 protein and processed mutant peptide in head and neck cancer. Clin Cancer Res. 2007 Dec 1;13(23):7199-7206.
Jiang, W.W.; Zahurak, M.; Zhou, Z.T.; Park, H.L.; Guo, Z.M.; Wu, G.J.; Sidransky, D.; Trink, B.; Califano, J.A. Alterations of GPI transamidase subunits in head and neck squamous carcinoma. Mol Cancer. 2007 Nov 21;6(1):74.
Kim, M.S.; Yamashita, K.; Chae, Y.K.; Tokumaru, Y.; Chang, X.; Zahurak, M.; Osada, M.; Park, H.L.; Chuang, A.; Califano, J.A.; Sidransky, D. A promoter methylation pattern in the N-methyl-D-aspartate receptor 2B gene predicts poor prognosis in esophageal squamous cell carcinoma. Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6658-6665.
Liu, C.; Zhou, S.; Begum, S.; Sidransky, D.; Westra, W.H.; Brock, M.; Califano, J.A. Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer. Lung Cancer. 2007 Mar;55(3):303-311.
Nayak, C.S.; Carvalho, A.L.; Jeronimo, C.; Henrique, R.; Kim, M.M.; Hoque, M.O.; Chang, S.; Jiang, W.W.; Koch, W.; Westra, W.; Sidransky, D.; Califano, J. Positive correlation of tissue inhibitor of metalloproteinase-3 and death-associated protein kinase hypermethylation in head and neck squamous cell carcinoma. Laryngoscope. 2007 Aug;117(8):1376-1380.
Osada, M.; Park, H.L.; Park, M.J.; Liu, J.W.; Wu, G.; Trink, B.; Sidransky, D. A p53-type response element in the GDF15 promoter confers high specificity for p53 activation. Biochem Biophys Res Commun. 2007 Mar 23;354(4):913-918.
Poeta, M.L.; Manola, J.; Goldwasser, M.A.; Forastiere, A.; Benoit, N.; Califano, J.A.; Ridge, J.A.; Goodwin, J.; Kenady, D.; Saunders, J.; Westra, W.; Sidransky, D.; Koch, W.M. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med. 2007 Dec 20;357(25):2552-2561.
Seng, T.J.; Low, J.S.; Li, H.; Cui, Y.; Goh, H.K.; Wong, M.L.; Srivastava, G.; Sidransky, D.; Califano, J.; Steenbergen, R.D.; Rha, S.Y.; Tan, J.; Hsieh, W.S.; Ambinder, R.F.; Lin, X.; Chan, A.T.; Tao, Q. The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation. Oncogene. 2007 Feb 8;26(6):934-944.
Trink, B.; Osada, M.; Ratovitski, E.; Sidransky, D. p63 transcriptional regulation of epithelial integrity and cancer. Cell Cycle. 2007 Feb;6(3):240-245.
Upadhyay, S.; Chatterjee, A.; Trink, B.; Sommer, M.; Ratovitski, E.; Sidransky, D. TAp63gamma regulates hOGG1 and repair of oxidative damage in cancer cell lines. Biochem Biophys Res Commun. 2007 May 18;356(4):823-828.
Zhou, S.; Kachhap, S.; Sun, W.; Wu, G.; Chuang, A.; Poeta, L.; Grumbine, L.; Mithani, S.K.; Chatterjee, A.; Koch, W.; Westra, W.H.; Maitra, A.; Glazer, C.; Carducci, M.; Sidransky, D.; McFate, T.; Verma, A.; Califano, J.A. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7540-7545.
Brait, M.; Begum, S.; Carvalho, A.L.; Dasgupta, S.; Vettore, A.L.; Czerniak, B.; Caballero, O.L.; Westra, W.H.; Sidransky, D.; Hoque, M.O. Aberrant Promoter Methylation of Multiple Genes during Pathogenesis of Bladder Cancer. Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2786-2794.
Carvalho, A.L.; Jeronimo, C.; Kim, M.M.; Henrique, R.; Zhang, Z.; Hoque, M.O.; Chang, S.; Brait, M.; Nayak, C.S.; Jiang, W.W.; Claybourne, Q.; Tokumaru, Y.; Lee, J.; Goldenberg, D.; Garrett-Mayer, E.; Goodman, S.; Moon, C.S.; Koch, W.; Westra, W.H.; Sidransky, D.; Califano, J.A. Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma. Clin Cancer Res. 2008 Jan 1;14(1):97-107.
Chae, Y.K.; Kang, S.K.; Kim, M.S.; Woo, J.; Lee, J.; Chang, S.; Kim, D.W.; Kim, M.; Park, S.; Kim, I.; Keam, B.; Rhee, J.; Koo, N.H.; Park, G.; Kim, S.H.; Jang, S.E.; Kweon, I.Y.; Sidransky, D.; Moon, C. Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML). PLoS ONE. 2008;3(7):e2594.
Chae, Y.K.; Woo, J.; Kim, M.J.; Kang, S.K.; Kim, M.S.; Lee, J.; Lee, S.K.; Gong, G.; Kim, Y.H.; Soria, J.C.; Jang, S.J.; Sidransky, D.; Moon, C. Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer. PLoS ONE. 2008;3(5):e2162.
Chang, S.S.; Jiang, W.W.; Smith, I.; Poeta, L.M.; Begum, S.; Glazer, C.; Shan, S.; Westra, W.; Sidransky, D.; Califano, J.A. MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer. 2008 Dec 15;123(12):2791-2797.
Chatterjee, A.; Chang, X.; Nagpal, J.K.; Chang, S.; Upadhyay, S.; Califano, J.; Trink, B.; Sidransky, D. Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from 2-methoxyestradiol-induced-mitochondria-dependent apoptosis. Oncogene. 2008 Jun 12;27(26):3710-3720.
Chatterjee, A.; Upadhyay, S.; Chang, X.; Nagpal, J.K.; Trink, B.; Sidransky, D. U-box-type ubiquitin E4 ligase, UFD2a attenuates cisplatin mediated degradation of DeltaNp63alpha. Cell Cycle. 2008 May 1;7(9):1231-1237.
Cui, Y.; Ying, Y.; van Hasselt, A.; Ng, K.M.; Yu, J.; Zhang, Q.; Jin, J.; Liu, D.; Rhim, J.S.; Rha, S.Y.; Loyo, M.; Chan, A.T.; Srivastava, G.; Tsao, G.S.; Sellar, G.C.; Sung, J.J.; Sidransky, D.; Tao, Q. OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation. PLoS ONE. 2008;3(8):e2990.
Dasgupta, S.; Hoque, M.O.; Upadhyay, S.; Sidransky, D. Mitochondrial cytochrome B gene mutation promotes tumor growth in bladder cancer. Cancer Res. 2008 Feb 1;68(3):700-706.
Gorelik, B.; Ziv, I.; Shohat, R.; Wick, M.; Hankins, W.D.; Sidransky, D.; Agur, Z. Efficacy of weekly docetaxel and bevacizumab in mesenchymal chondrosarcoma: a new theranostic method combining xenografted biopsies with a mathematical model. Cancer Res. 2008 Nov 1;68(21):9033-9040.
Hoque, M.O.; Begum, S.; Brait, M.; Jeronimo, C.; Zahurak, M.; Ostrow, K.L.; Rosenbaum, E.; Trock, B.; Westra, W.H.; Schoenberg, M.; Goodman, S.N.; Sidransky, D. Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer. J Urol. 2008 Feb;179(2):743-747.
Hoque, M.O.; Kim, M.S.; Ostrow, K.L.; Liu, J.; Wisman, G.B.; Park, H.L.; Poeta, M.L.; Jeronimo, C.; Henrique, R.; Lendvai, A.; Schuuring, E.; Begum, S.; Rosenbaum, E.; Ongenaert, M.; Yamashita, K.; Califano, J.; Westra, W.; van der Zee, A.G.; Van Criekinge, W.; Sidransky, D. Genome-wide promoter analysis uncovers portions of the cancer methylome. Cancer Res. 2008 Apr 15;68(8):2661-2670.
Huang, Y.; Hoque, M.O.; Wu, F.; Trink, B.; Sidransky, D.; Ratovitski, E.A. Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes. Cell Cycle. 2008 Jun 1;7(11):1613-1622.
Huang, Y.; Sen, T.; Nagpal, J.; Upadhyay, S.; Trink, B.; Ratovitski, E.; Sidransky, D. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell Cycle. 2008 Sep 15;7(18):2846-2855.
Jakupciak, J.P.; Maragh, S.; Markowitz, M.E.; Greenberg, A.K.; Hoque, M.O.; Maitra, A.; Barker, P.E.; Wagner, P.D.; Rom, W.N.; Srivastava, S.; Sidransky, D.; O'Connell, C.D. Performance of mitochondrial DNA mutations detecting early stage cancer. BMC Cancer. 2008;8:285.
Jeronimo, C.; Monteiro, P.; Henrique, R.; Dinis-Ribeiro, M.; Costa, I.; Costa, V.L.; Filipe, L.; Carvalho, A.L.; Hoque, M.O.; Pais, I.; Leal, C.; Teixeira, M.R.; Sidransky, D. Quantitative hypermethylation of a small panel of genes augments the diagnostic accuracy in fine-needle aspirate washings of breast lesions. Breast Cancer Res Treat. 2008 May;109(1):27-34.
Kang, S.K.; Chae, Y.K.; Woo, J.; Kim, M.S.; Park, J.C.; Lee, J.; Soria, J.C.; Jang, S.J.; Sidransky, D.; Moon, C. Role of human aquaporin 5 in colorectal carcinogenesis. Am J Pathol. 2008 Aug;173(2):518-525.
Kim, M.S.; Lebron, C.; Nagpal, J.K.; Chae, Y.K.; Chang, X.; Huang, Y.; Chuang, T.; Yamashita, K.; Trink, B.; Ratovitski, E.A.; Califano, J.A.; Sidransky, D. Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer. Biochem Biophys Res Commun. 2008 May 23;370(1):38-43.
Liu, J.W.; Nagpal, J.K.; Jeronimo, C.; Lee, J.E.; Henrique, R.; Kim, M.S.; Ostrow, K.L.; Yamashita, K.; van Criekinge, V.; Wu, G.; Moon, C.S.; Trink, B.; Sidransky, D. Hypermethylation of MCAM gene is associated with advanced tumor stage in prostate cancer. Prostate. 2008 Mar 1;68(4):418-426.
Liu, J.W.; Nagpal, J.K.; Sun, W.; Lee, J.; Kim, M.S.; Ostrow, K.L.; Zhou, S.; Jeronimo, C.; Henrique, R.; Van Criekinge, W.; Moon, C.S.; Califano, J.A.; Trink, B.; Sidransky, D. ssDNA-binding protein 2 is frequently hypermethylated and suppresses cell growth in human prostate cancer. Clin Cancer Res. 2008 Jun 15;14(12):3754-3760.
Maragh, S.; Jakupciak, J.P.; Wagner, P.D.; Rom, W.N.; Sidransky, D.; Srivastava, S.; O'Connell, C.D. Multiple strand displacement amplification of mitochondrial DNA from clinical samples. BMC medical genetics. 2008;9:7.
Moon, C.S.; Agbo, E.C.; Sidransky, D. Slow development impedes the uptake of diagnostics. Nature. 2008 Jan 3;451(7174):16.
Nagpal, J.K.; Dasgupta, S.; Jadallah, S.; Chae, Y.K.; Ratovitski, E.A.; Toubaji, A.; Netto, G.J.; Eagle, T.; Nissan, A.; Sidransky, D.; Trink, B. Profiling the expression pattern of GPI transamidase complex subunits in human cancer. Mod Pathol. 2008 Aug;21(8):979-991.
Park, H.L.; Kim, M.S.; Yamashita, K.; Westra, W.; Carvalho, A.L.; Lee, J.; Jiang, W.W.; Baek, J.H.; Liu, J.; Osada, M.; Moon, C.S.; Califano, J.A.; Mori, M.; Sidransky, D. DCC promoter hypermethylation in esophageal squamous cell carcinoma. Int J Cancer. 2008 Jun 1;122(11):2498-2502.
Park, J.C.; Chae, Y.K.; Son, C.H.; Kim, M.S.; Lee, J.; Ostrow, K.; Sidransky, D.; Hoque, M.O.; Moon, C. Epigenetic silencing of human T (brachyury homologue) gene in non-small-cell lung cancer. Biochem Biophys Res Commun. 2008 Jan 11;365(2):221-226.
Sidransky, D. The oral cavity as a molecular mirror of lung carcinogenesis. Cancer prevention research (Philadelphia, Pa. 2008 Jun;1(1):12-14.
Tokumaru, Y.; Yamashita, K.; Kim, M.S.; Park, H.L.; Osada, M.; Mori, M.; Sidransky, D. The role of PGP9.5 as a tumor suppressor gene in human cancer. Int J Cancer. 2008 Aug 15;123(4):753-759.
Westra, W.H.; Taube, J.M.; Poeta, M.L.; Begum, S.; Sidransky, D.; Koch, W.M. Inverse Relationship between Human Papillomavirus-16 Infection and Disruptive p53 Gene Mutations in Squamous Cell Carcinoma of the Head and Neck. Clin Cancer Res. 2008 Jan 15;14(2):366-369.
Woo, J.; Chae, Y.K.; Jang, S.J.; Kim, M.S.; Baek, J.H.; Park, J.C.; Trink, B.; Ratovitski, E.; Lee, T.; Park, B.; Park, M.; Kang, J.H.; Soria, J.C.; Lee, J.; Califano, J.; Sidransky, D.; Moon, C. Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium. Biochem Biophys Res Commun. 2008 Feb 8;366(2):321-327.
Woo, J.; Lee, J.; Chae, Y.K.; Kim, M.S.; Baek, J.H.; Park, J.C.; Park, M.J.; Smith, I.M.; Trink, B.; Ratovitski, E.; Lee, T.; Park, B.; Jang, S.J.; Soria, J.C.; Califano, J.A.; Sidransky, D.; Moon, C. Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation. Cancer Lett. 2008 Jun 8;264(1):54-62.
Woo, J.; Lee, J.; Kim, M.S.; Jang, S.J.; Sidransky, D.; Moon, C. The effect of aquaporin 5 overexpression on the Ras signaling pathway. Biochem Biophys Res Commun. 2008 Mar 7;367(2):291-298.
Yamashita, K.; Kim, M.S.; Park, H.L.; Tokumaru, Y.; Osada, M.; Inoue, H.; Mori, M.; Sidransky, D. HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma. Mol Cancer Res. 2008 Jan;6(1):31-41.
Brait, M.; Ford, J.G.; Papaiahgari, S.; Garza, M.A.; Lee, J.I.; Loyo, M.; Maldonado, L.; Begum, S.; McCaffrey, L.; Howerton, M.; Sidransky, D.; Emerson, M.R.; Ahmed, S.; Williams, C.D.; Hoque, M.O. Association between lifestyle factors and CpG island methylation in a cancer-free population. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2984-2991.
Ha, P.K.; Chang, S.S.; Glazer, C.A.; Califano, J.A.; Sidransky, D. Molecular techniques and genetic alterations in head and neck cancer. Oral Oncol. 2009 Jul 30;45:335-339.
Ostrow, K.L.; Park, H.L.; Hoque, M.O.; Kim, M.S.; Liu, J.; Argani, P.; Westra, W.; Van Criekinge, W.; Sidransky, D. Pharmacologic unmasking of epigenetically silenced genes in breast cancer. Clin Cancer Res. 2009 Feb 15;15(4):1184-1191.
Poeta, M.L.; Manola, J.; Goldenberg, D.; Forastiere, A.; Califano, J.A.; Ridge, J.A.; Goodwin, J.; Kenady, D.; Saunders, J.; Westra, W.; Sidransky, D.; Koch, W.M. The Ligamp TP53 Assay for Detection of Minimal Residual Disease in Head and Neck Squamous Cell Carcinoma Surgical Margins. Clin Cancer Res. 2009 Dec 15;15(24):7658-7665.
Slager, J.; Tyler, B.; Shikanov, A.; Domb, A.J.; Shogen, K.; Sidransky, D.; Brem, H. Local controlled delivery of anti-neoplastic RNAse to the brain. Pharmaceutical research. 2009 Aug;26(8):1838-1846.
Chang, X.; Monitto, C.L.; Demokan, S.; Kim, M.S.; Chang, S.S.; Zhong, X.; Califano, J.A.; Sidransky, D. Identification of hypermethylated genes associated with cisplatin resistance in human cancers. Cancer Res. 2010 Apr 1;70(7):2870-2879.
Dasgupta, S.; Koch, R.; Westra, W.H.; Califano, J.A.; Ha, P.K.; Sidransky, D.; Koch, W.M. Mitochondrial DNA mutation in normal margins and tumors of recurrent head and neck squamous cell carcinoma patients. Cancer Prev Res (Phila). 2010 Sep;3(9):1205-1211.
Demokan, S.; Chang, X.; Chuang, A.; Mydlarz, W.K.; Kaur, J.; Huang, P.; Khan, Z.; Khan, T.; Ostrow, K.L.; Brait, M.; Hoque, M.O.; Liegeois, N.J.; Sidransky, D.; Koch, W.; Califano, J.A. KIF1A and EDNRB are differentially methylated in primary HNSCC and salivary rinses. Int J Cancer. 2010 Nov 15;127(10):2351-2359.
Durr, M.L.; Mydlarz, W.K.; Shao, C.; Zahurak, M.L.; Chuang, A.Y.; Hoque, M.O.; Westra, W.H.; Liegeois, N.J.; Califano, J.A.; Sidransky, D.; Ha, P.K. Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors. PLoS One. 2010;5(5):e10828.
Hoque, M.O.; Brait, M.; Rosenbaum, E.; Poeta, M.L.; Pal, P.; Begum, S.; Dasgupta, S.; Carvalho, A.L.; Ahrendt, S.A.; Westra, W.H.; Sidransky, D. Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer. J Thorac Oncol. 2010 Dec;5(12):1887-1893.
Huang, Y.; Chang, X.; Lee, J.; Cho, Y.G.; Zhong, X.; Park, I.S.; Liu, J.W.; Califano, J.A.; Ratovitski, E.A.; Sidransky, D.; Kim, M.S. Cigarette smoke induced promoter methylation of single-strand DNA-binding protein 2 in human esophageal squamous cell carcinoma. Int J Cancer. 2010 Jul 23.
Lee, J.; Jang, S.J.; Benoit, N.; Hoque, M.O.; Califano, J.A.; Trink, B.; Sidransky, D.; Mao, L.; Moon, C. Presence of 5-methylcytosine in CpNpG trinucleotides in the human genome. Genomics. 2010 Aug;96(2):67-72.
Loyo, M.; Brait, M.; Kim, M.S.; Ostrow, K.L.; Jie, C.C.; Chuang, A.Y.; Califano, J.A.; Liegeois, N.J.; Begum, S.; Westra, W.H.; Hoque, M.O.; Tao, Q.; Sidransky, D. A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma. Int J Cancer. 2010 May 6.
Loyo, M.; Guerrero-Preston, R.; Brait, M.; Hoque, M.O.; Chuang, A.; Kim, M.S.; Sharma, R.; Liegeois, N.J.; Koch, W.M.; Califano, J.A.; Westra, W.H.; Sidransky, D. Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission. Int J Cancer. 2010 Jun 15;126(12):2991-2996.
Pattani, K.M.; Zhang, Z.; Demokan, S.; Glazer, C.; Loyo, M.; Goodman, S.; Sidransky, D.; Bermudez, F.; Jean-Charles, G.; McCaffrey, T.; Padhya, T.; Phelan, J.; Spivakovsky, S.; Bowne, H.Y.; Goldberg, J.D.; Rolnitzky, L.; Robbins, M.; Kerr, A.R.; Sirois, D.; Califano, J.A. Endothelin receptor type B gene promoter hypermethylation in salivary rinses is independently associated with risk of oral cavity cancer and premalignancy. Cancer Prev Res (Phila). 2010 Sep;3(9):1093-1103.
Roh, J.L.; Kang, S.K.; Minn, I.; Califano, J.A.; Sidransky, D.; Koch, W.M. p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. Oral Oncol. 2010 Dec 15.

 

Read Our Blogs
Cancer Matters: timely topics
Our Cancer: for caregivers

Traveling for care?

blue suitcase

Whether crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins.

Maryland 410-955-5222
U.S. 410-955-5222
International +1-410-614-6424

NCI CCC

 
 
 
 
 

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.

Privacy Policy and Disclaimer