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Dr. Jun Liu

Ph.D.
Schools\Degrees

B.S. in Chemistry, Nanjing University, Nanjing, China M.S. in Organic Chemistry, The Ohio State University, Columbus, OH Ph.D. in Biochemistry, Massachusetts Institute of Technology, Cambridge, MA

Training

Director, Graduate Program in Pharmacology, Johns Hopkins School of Medicine
Co-Director, Keck Center for the Rational Design of Biologically Active Molecules
Professor, Department of Oncology, Johns Hopkins School of Medicine
Professor, Department of Pharmacology, Johns Hopkins School of Medicine
Professor, Department of Neuroscience, Johns Hopkins School of Medicine
Associate Professor, Center for Cancer Research, Departments of Biology and Chemistry, Massachusetts Institute of Technology
Assistant Professor, Center for Cancer Research, Departments of Biology and Chemistry, Massachusetts Institute of Technology
Research Associate, National Institute of Child Health and Human Development, National Institutes of Health
Postdoctoral Fellow, Department of Chemistry, Harvard University
Research Associate, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Research Associate, Departments of Chemistry and Biology, Massachusetts Institute of Technology
Research Associate, Department of Chemistry, The Ohio State University.

Journal Citations

Lee, K.; Qian, D.Z.; Rey, S.; Wei, H.; Liu, J.O.; Semenza, G.L. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2353-2358.

Lee, K.; Zhang, H.; Qian, D.Z.; Rey, S.; Liu, J.O.; Semenza, G.L. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17910-17915.

Ostrow, K.L.; Park, H.L.; Hoque, M.O.; Kim, M.S.; Liu, J.; Argani, P.; Westra, W.; Van Criekinge, W.; Sidransky, D. Pharmacologic unmasking of epigenetically silenced genes in breast cancer. Clin Cancer Res. 2009 Feb 15;15(4):1184-1191.

Pan, F.; Yu, H.; Dang, E.V.; Barbi, J.; Pan, X.; Grosso, J.F.; Jinasena, D.; Sharma, S.M.; McCadden, E.M.; Getnet, D.; Drake, C.G.; Liu, J.O.; Ostrowski, M.C.; Pardoll, D.M. Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science. 2009 Aug 28;325(5944):1142-1146.

Shim, J.S.; Matsui, Y.; Bhat, S.; Nacev, B.A.; Xu, J.; Bhang, H.E.; Dhara, S.; Han, K.C.; Chong, C.R.; Pomper, M.G.; So, A.; Liu, J.O. Effect of nitroxoline on angiogenesis and growth of human bladder cancer. J Natl Cancer Inst. 2010 Dec 15;102(24):1855-1873.

Wu, Z.J.; Meyer, C.A.; Choudhury, S.; Shipitsin, M.; Maruyama, R.; Bessarabova, M.; Nikolskaya, T.; Sukumar, S.; Schwartzman, A.; Liu, J.S.; Polyak, K.; Liu, X.S. Gene expression profiling of human breast tissue samples using SAGE-Seq. Genome Res. 2010 Dec;20(12):1730-1739.

Xu, J.; Dang, Y.; Ren, Y.R.; Liu, J.O. Cholesterol trafficking is required for mTOR activation in endothelial cells. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4764-4769.

Lin, J.; Haffner, M.C.; Zhang, Y.; Lee, B.H.; Brennen, W.N.; Britton, J.; Kachhap, S.K.; Shim, J.S.; Liu, J.O.; Nelson, W.G.; Yegnasubramanian, S.; Carducci, M.A. Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth. Prostate. 2011 Mar 1;71(4):333-343.

Liu, J.O.; Titov, D.V.; Dang, Y.; He, Q. Regulator of Ras depalmitoylation and retrograde trafficking: a new hat for FKBP. Mol Cell. 2011 Jan 21;41(2):131-133.

Titov, D.V.; Gilman, B.; He, Q.L.; Bhat, S.; Low, W.K.; Dang, Y.; Smeaton, M.; Demain, A.L.; Miller, P.S.; Kugel, J.F.; Goodrich, J.A.; Liu, J.O. XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol. 2011 Mar;7(3):182-188.

 

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