//
Skip Navigation
 
 
 
 
 
Print This Page
Share this page: More
 

Dr. Justin Hanes

Ph.D.
Justin Hanes
Titles

Associate Professor of Chemical and Biomolecular Engineering, Johns Hopkins Whiting School of Engineering

Journal Citations

Hanes, J. W., Thal, D. M. & Johnson, K. A. (2006). Incorporation and replication of 8-oxo-deoxyguanosine by the human mitochondrial DNA polymerase. J Biol Chem 281, 36241-8.

Hanes, J.W., and Johnson, K.A. (2008). Exonuclease removal of dideoxycytidine (zalcitabine) by the human mitochondrial DNA polymerase. Antimicrob Agents Chemother 52, 253-258.

Hanes, J.W., and Johnson, K.A. (2008). Real-time measurement of pyrophosphate release kinetics. Anal Biochem 372, 125-127.

Hanes, J.W., Burns, K.E., Hilmey, D.G., Chatterjee, A., Dorrestein, P.C., and Begley, T.P. (2008). Mechanistic studies on pyridoxal phosphate synthase: the reaction pathway leading to a chromophoric intermediate. J Am Chem Soc 130, 3043-3052.

Hanes, J.W., Keresztes, I., and Begley, T.P. (2008). 13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase. Nat Chem Biol 4, 425-430.

Hanes, J.W., Keresztes, I., and Begley, T.P. (2008). Trapping of a chromophoric intermediate in the Pdx1-catalyzed biosynthesis of pyridoxal 5'-phosphate. Angew Chem Int Ed Engl 47, 2102-2105.

Hida, K., J. Hanes, and M. Ostermeier. 2007. Directed evolution for drug and nucleic acid delivery. Adv Drug Deliv Rev 59:1562-78.

Ivanovova, N., Handzusova, M., Hanes, J., Kontsekova, E., and Novak, M. (2008). High-yield purification of fetal tau preserving its structure and phosphorylation pattern. J Immunol Methods 339, 17-22.

Lai, S. K., D. E. O'Hanlon, S. Harrold, S. T. Man, Y. Y. Wang, R. Cone, and J. Hanes. 2007. Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc Natl Acad Sci U S A 104:1482-7.

Lai, S. K., K. Hida, C. Chen, and J. Hanes. 2008. Characterization of the intracellular dynamics of a non-degradative pathway accessed by polymer nanoparticles. J Control Release 125:107-11.

Lai, S. K., K. Hida, S. T. Man, C. Chen, C. Machamer, T. A. Schroer, and J. Hanes. 2007. Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway. Biomaterials 28:2876-84.

Soriano, E.V., Rajashankar, K.R., Hanes, J.W., Bale, S., Begley, T.P., and Ealick, S.E. (2008). Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor. Biochemistry 47, 1346-1357.

Suh, J., Dawson, M. & Hanes, J. (2005). Real-time multiple-particle tracking: applications to drug and gene delivery. Adv Drug Deliv Rev 57, 63-78.

Suk, J. S., J. Suh, S. K. Lai, and J. Hanes. 2007. Quantifying the intracellular transport of viral and nonviral gene vectors in primary neurons. Exp Biol Med (Maywood) 232:461-9.

Suk, J. S., Suh, J., Choy, K., Lai, S. K., Fu, J. & Hanes, J. (2006). Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles. Biomaterials 27, 5143-50.

Suk, J.S., Lai, S.K., Wang, Y.Y., Ensign, L.M., Zeitlin, P.L., Boyle, M.P., and Hanes, J. (2009). The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles. Biomaterials.

Wei, C., N. Liu, P. Xu, M. Heller, D. A. Tomalia, D. T. Haynie, E. H. Chang, K. Wang, Y. S. Lee, Y. L. Lyubchenko, R. Bawa, R. Tian, J. Hanes, S. Pun, J. C. Meiners, and P. Guo. 2007. From bench to bedside: successful translational nanomedicine: highlights of the Third Annual Meeting of the American Academy of Nanomedicine. Nanomedicine 3:322-31.

Hanes, J.W.; Burns, K.E.; Hilmey, D.G.; Chatterjee, A.; Dorrestein, P.C.; Begley, T.P. Mechanistic studies on pyridoxal phosphate synthase: the reaction pathway leading to a chromophoric intermediate. J Am Chem Soc. 2008 Mar 12;130(10):3043-3052.

Hanes, J.W.; Johnson, K.A. Exonuclease removal of dideoxycytidine (zalcitabine) by the human mitochondrial DNA polymerase. Antimicrob Agents Chemother. 2008 Jan;52(1):253-258.

Hanes, J.W.; Johnson, K.A. Real-time measurement of pyrophosphate release kinetics. Anal Biochem. 2008 Jan 1;372(1):125-127.

Hanes, J.W.; Keresztes, I.; Begley, T.P. 13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase. Nat Chem Biol. 2008 Jul;4(7):425-430.

Ivanovova, N.; Handzusova, M.; Hanes, J.; Kontsekova, E.; Novak, M. High-yield purification of fetal tau preserving its structure and phosphorylation pattern. J Immunol Methods. 2008 Nov 30;339(1):17-22.

Lai, S.K.; Hida, K.; Chen, C.; Hanes, J. Characterization of the intracellular dynamics of a non-degradative pathway accessed by polymer nanoparticles. J Control Release. 2008 Jan 22;125(2):107-111.

Soriano, E.V.; Rajashankar, K.R.; Hanes, J.W.; Bale, S.; Begley, T.P.; Ealick, S.E. Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor. Biochemistry. 2008 Feb 5;47(5):1346-1357.

Bale, S.; Brooks, W.; Hanes, J.W.; Mahesan, A.M.; Guida, W.C.; Ealick, S.E. Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase. Biochemistry. 2009 Jul 14;48(27):6423-6430.

Hanes, J.; Demeester, J. Drug and gene delivery to mucosal tissues: the mucus barrier. Preface. Adv Drug Deliv Rev. 2009 Feb 27;61(2):73-74.

Hanes, J.; Zilka, N.; Bartkova, M.; Caletkova, M.; Dobrota, D.; Novak, M. Rat tau proteome consists of six tau isoforms: implication for animal models of human tauopathies. J Neurochem. 2009 Mar;108(5):1167-1176.

Lai, S.K.; Hida, K.; Shukair, S.; Wang, Y.Y.; Figueiredo, A.; Cone, R.; Hope, T.J.; Hanes, J. Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus. J Virol. 2009 Nov;83(21):11196-11200.

Lai, S.K.; Wang, Y.Y.; Cone, R.; Wirtz, D.; Hanes, J. Altering mucus rheology to "solidify" human mucus at the nanoscale. PLoS One. 2009;4(1):e4294.

Lai, S.K.; Wang, Y.Y.; Hanes, J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev. 2009 Feb 27;61(2):158-171.

Lai, S.K.; Wang, Y.Y.; Wirtz, D.; Hanes, J. Micro- and macrorheology of mucus. Adv Drug Deliv Rev. 2009 Feb 27;61(2):86-100.

Suk, J.S.; Lai, S.K.; Wang, Y.Y.; Ensign, L.M.; Zeitlin, P.L.; Boyle, M.P.; Hanes, J. The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles. Biomaterials. 2009 Jan 26.

Tang, B.C.; Dawson, M.; Lai, S.K.; Wang, Y.Y.; Suk, J.S.; Yang, M.; Zeitlin, P.; Boyle, M.P.; Fu, J.; Hanes, J. Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19268-19273.

Hida, K.; Won, S.Y.; Di Pasquale, G.; Hanes, J.; Chiorini, J.A.; Ostermeier, M. Sites in the AAV5 capsid tolerant to deletions and tandem duplications. Arch Biochem Biophys. 2010 Apr 1;496(1):1-8.

Lai, S.K.; Wang, Y.Y.; Hida, K.; Cone, R.; Hanes, J. Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):598-603.

Tang, B.C.; Fu, J.; Watkins, D.N.; Hanes, J. Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo. Biomaterials. 2010 Jan;31(2):339-344.

 

Read Our Blogs
Cancer Matters: timely topics
Our Cancer: for caregivers

Traveling for care?

blue suitcase

Whether crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins.

Maryland 410-955-5222
U.S. 410-955-5222
International +1-410-614-6424

NCI CCC

 
 
 
 
 

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.

Privacy Policy and Disclaimer