Titles

Assistant Professor
Stem Cell Biology Laboratory
Department of Oncology

Training

1998 M.D. School of Medicine, Chung-Ang University, Seoul, Korea

2002 Ph.D. School of Medicine, Pharmacology, Chung-Ang University, Seoul, Korea

2002-2004 Postdoctoral training, Johns Hopkins Medical Institutions, Baltimore, MD. USA

Certifications

License of Medical Doctor in the Republic of Korea License of Radio-Isotope Special Management in Republic of Korea

Research Summary

Dr. Jang’s laboratory research is focused on the elucidation of fundamental biology and pathophysiology of pluripotent and multipotent stem cells. Active areas of work include:

Identification of normal and cancer stem cell niches and their roles for the cancer develpment and therapy.

Differentiation of stem cells into functional hepatatic cells.

Generation of patient iPS cells from neoplastic and non-neoplastic liver diseases and Disease modeling in vitro and in vivo.

Journal Citations

Jang, Y.Y.; Sharkis, S.J. Fetal to adult stem cell transition: knocking Sox17 off. Cell. 2007 Aug 10;130(3):403-404.

Jang, Y.Y.; Sharkis, S.J. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood. 2007 Oct 15;110(8):3056-3063.

Ye, Z.; Zhan, H.; Mali, P.; Dowey, S.; Williams, D.M.; Jang, Y.Y.; Dang, C.V.; Spivak, J.L.; Moliterno, A.R.; Cheng, L. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood. 2009 Dec 24;114(27):5473-5480.

Chun, Y.S.; Chaudhari, P.; Jang, Y.Y. Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease. Int J Biol Sci. 2010;6(7):796-805.

Liu, H.; Ye, Z.; Kim, Y.; Sharkis, S.; Jang, Y.Y. Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes. Hepatology. 2010 May;51(5):1810-1819.