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Dr. Alison Klein

Ph.D., M.H.S.
Alison Klein
Interests

Pancreatic Cancer, Genetic Epidemiology, Inherited Cancer Syndromes, Risk Assesment

Titles

Assistant Professor of Oncology and Pathology
Director of the National Familial Pancreas Tumor Registry at Johns Hopkins
Joint Appointment in Epidemiology, Johns Hopkins Bloomberg School of Public Health

Schools\Degrees

M.H.S., Biostatistics, Johns Hopkins Bloomberg School of Public Health Ph.D., Epidemiology, Johns Hopkins Bloomberg School of Public Health

Training

Research Fellow, National Human Genome Research Institute, National Institutes of Health

Research Summary

Dr. Klein is the Director of the National Familial Pancreas Tumor Registry, the largest pancreatic cancer family registry in the world (www.nfptr.org). She is a genetic epidemiologist with a focus on cancer research. Her current work focuses on the identification the genetic and environmental risk factors for pancreatic cancer as well as other complex genetic diseases. Recently, in the first demonstration that whole exome sequencing approaches can be used to identify the causes of a hereditary disease, she discovered that mutations in the PALB2 gene increase the risk of pancreatic cancer. In addition, she has developed a clinical risk assessment tool for high-risk pancreatic cancer families, PancPRO in order to facilitate the translation of her research findings into the clinical setting.

Journal Citations

Sebastiani, V.; Ricci, F.; Rubio-Viquiera, B.; Kulesza, P.; Yeo, C.J.; Hidalgo, M.; Klein, A.; Laheru, D.; Iacobuzio-Donahue, C.A. Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival. Clin Cancer Res. 2006 Apr 15;12(8):2492-2497.

Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Angenendt, P.; Mankoo, P.; Carter, H.; Kamiyama, H.; Jimeno, A.; Hong, S.M.; Fu, B.; Lin, M.T.; Calhoun, E.S.; Kamiyama, M.; Walter, K.; Nikolskaya, T.; Nikolsky, Y.; Hartigan, J.; Smith, D.R.; Hidalgo, M.; Leach, S.D.; Klein, A.P.; Jaffee, E.M.; Goggins, M.; Maitra, A.; Iacobuzio-Donahue, C.; Eshleman, J.R.; Kern, S.E.; Hruban, R.H.; Karchin, R.; Papadopoulos, N.; Parmigiani, G.; Vogelstein, B.; Velculescu, V.E.; Kinzler, K.W. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008 Sep 26;321(5897):1801-1806.

Steinhardt, A.A.; Gayyed, M.F.; Klein, A.P.; Dong, J.; Maitra, A.; Pan, D.; Montgomery, E.A.; Anders, R.A. Expression of Yes-associated protein in common solid tumors. Hum Pathol. 2008 Aug 12.

Axilbund, J.E.; Argani, P.; Kamiyama, M.; Palmisano, E.; Raben, M.; Borges, M.; Brune, K.A.; Goggins, M.; Hruban, R.H.; Klein, A.P. Absence of germline BRCA1 mutations in familial pancreatic cancer patients. Cancer Biol Ther. 2009 Jan;8(2):131-135.

Blackford, A.; Parmigiani, G.; Kensler, T.W.; Wolfgang, C.; Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Eshleman, J.R.; Goggins, M.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Klein, A.; Cameron, J.L.; Olino, K.; Schulick, R.; Winter, J.; Vogelstein, B.; Velculescu, V.E.; Kinzler, K.W.; Hruban, R.H. Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res. 2009 Apr 15;69(8):3681-3688.

Blackford, A.; Serrano, O.K.; Wolfgang, C.L.; Parmigiani, G.; Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Eshleman, J.R.; Goggins, M.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Cameron, J.L.; Olino, K.; Schulick, R.; Winter, J.; Herman, J.M.; Laheru, D.; Klein, A.P.; Vogelstein, B.; Kinzler, K.W.; Velculescu, V.E.; Hruban, R.H. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009 Jul 15;15(14):4674-4679.

Jones, S.; Hruban, R.H.; Kamiyama, M.; Borges, M.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Palmisano, E.; Brune, K.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Parmigiani, G.; Kern, S.E.; Velculescu, V.E.; Kinzler, K.W.; Vogelstein, B.; Eshleman, J.R.; Goggins, M.; Klein, A.P. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science. 2009 Apr 10;324(5924):217.

Wang, L.; Brune, K.A.; Visvanathan, K.; Laheru, D.; Herman, J.; Wolfgang, C.; Schulick, R.; Cameron, J.L.; Goggins, M.; Hruban, R.H.; Klein, A.P. Elevated cancer mortality in the relatives of patients with pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2829-2834.

Brune, K.A.; Lau, B.; Palmisano, E.; Canto, M.; Goggins, M.G.; Hruban, R.H.; Klein, A.P. Importance of age of onset in pancreatic cancer kindreds. J Natl Cancer Inst. 2010 Jan 20;102(2):119-126.

Hruban, R.H.; Canto, M.I.; Goggins, M.; Schulick, R.; Klein, A.P. Update on familial pancreatic cancer. Adv Surg. 2010;44:293-311.

Lennon, A.M.; Klein, A.P.; Goggins, M. ABO blood group and other genetic variants associated with pancreatic cancer. Genome Med. 2010;2(6):39.

Petersen, G.M.; Amundadottir, L.; Fuchs, C.S.; Kraft, P.; Stolzenberg-Solomon, R.Z.; Jacobs, K.B.; Arslan, A.A.; Bueno-de-Mesquita, H.B.; Gallinger, S.; Gross, M.; Helzlsouer, K.; Holly, E.A.; Jacobs, E.J.; Klein, A.P.; LaCroix, A.; Li, D.; Mandelson, M.T.; Olson, S.H.; Risch, H.A.; Zheng, W.; Albanes, D.; Bamlet, W.R.; Berg, C.D.; Boutron-Ruault, M.C.; Buring, J.E.; Bracci, P.M.; Canzian, F.; Clipp, S.; Cotterchio, M.; de Andrade, M.; Duell, E.J.; Gaziano, J.M.; Giovannucci, E.L.; Goggins, M.; Hallmans, G.; Hankinson, S.E.; Hassan, M.; Howard, B.; Hunter, D.J.; Hutchinson, A.; Jenab, M.; Kaaks, R.; Kooperberg, C.; Krogh, V.; Kurtz, R.C.; Lynch, S.M.; McWilliams, R.R.; Mendelsohn, J.B.; Michaud, D.S.; Parikh, H.; Patel, A.V.; Peeters, P.H.; Rajkovic, A.; Riboli, E.; Rodriguez, L.; Seminara, D.; Shu, X.O.; Thomas, G.; Tjonneland, A.; Tobias, G.S.; Trichopoulos, D.; Van Den Eeden, S.K.; Virtamo, J.; Wactawski-Wende, J.; Wang, Z.; Wolpin, B.M.; Yu, H.; Yu, K.; Zeleniuch-Jacquotte, A.; Fraumeni, J.F., Jr.; Hoover, R.N.; Hartge, P.; Chanock, S.J. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010 Mar;42(3):224-228.

Villarroel, M.C.; Rajeshkumar, N.V.; Garrido-Laguna, I.; De Jesus-Acosta, A.; Jones, S.; Maitra, A.; Hruban, R.H.; Eshleman, J.R.; Klein, A.; Laheru, D.; Donehower, R.; Hidalgo, M. Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer. Mol Cancer Ther. 2011 Jan;10(1):3-8.

 

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